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Cat. No.: HY-183923

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SX 3202

SX 3202 is an aldose reductase inhibitor. SX 3202 can be used for the research of diabetic complications.

For research use only. We do not sell to patients.

CAS No.: 147254-65-7
Formula: C₁₇H₁₁BrFN₃O₄
Molecular Weight:420.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SX 3202 Chemical Structure

CAS No.: 147254-65-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
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Biological Activity

Description

SX 3202 is an aldose reductase inhibitor. SX 3202 can be used for the research of diabetic complications^[1].

In Vitro

SX 3202 (1 min) inhibits purified porcine lens aldose reductase with an IC₅₀ of 0.19 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SX 3202 (>100 mg/kg; p.o.; daily; 5 days) shows very weak in vivo aldose reductase inhibitory activity, with an ED₅₀ greater than 100 mg/kg/day for reducing sciatic nerve sorbitol accumulation in Streptozotocin (HY-13753)-induced diabetic rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 147254-65-7
Molecular Weight 420.19
Formula C₁₇H₁₁BrFN₃O₄
SMILES

O=C1[C@@]2(CC(NC2=O)=O)N3C(C(N1CC4=C(C=C(C=C4)Br)F)=O)=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Negoro T, et al. Novel, highly potent aldose reductase inhibitors: (R)-(-)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4- tetrahydropyrrolo[1,2-a]pyrazine -4-spiro-3'-pyrrolidine-1,2',3,5'-tetrone (AS-3201) and its congeners. J Med Chem. 1998;41(21):4118-4129. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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