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Cat. No.: HY-183855

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WF-2421

WF-2421 is an aldose reductase inhibitor with an IC₅₀ of 0.03 μM against rabbit-derived aldose reductase. WF-2421 acts as a non-competitive inhibitor of aldose reductase using dl-glyceraldehyde as the substrate. WF-2421 can be used in the research of diabetic complications (cataract, neuropathy, retinopathy, nephropathy).

For research use only. We do not sell to patients.

CAS No.: 128429-19-6
Formula: C₁₉H₂₀N₂O₈
Molecular Weight:404.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

WF-2421 Chemical Structure

CAS No.: 128429-19-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

WF-2421 (2 minutes) potently inhibits partially purified rabbit lens aldose reductase with an IC₅₀ of 0.03 μM, acting as an uncompetitive inhibitor relative to DL-glyceraldehyde (HY-128748)^[1].
WF-2421 sodium salt exhibits no antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Trichophyton asteroides, or Candida albicans at 1 mg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 128429-19-6
Molecular Weight 404.37
Formula C₁₉H₂₀N₂O₈
SMILES

O=CNCC(C1=CC(C2=CC(C(C(C(O)=O)NC=O)O)=CC=C2O)=C(O)C=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nishikawa M, et al. WF-2421, a new aldose reductase inhibitor produced from a fungus, Humicola grisea. J Antibiot (Tokyo). 1991;44(2):130-135. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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