WF-2421, a new aldose reductase inhibitor produced from a fungus, Humicola grisea

  • J Antibiot (Tokyo). 1991 Feb;44(2):130-5. doi: 10.7164/antibiotics.44.130.
M Nishikawa  1 ,  Y Tsurumi ,  H Murai ,  K Yoshida ,  M Okamoto ,  S Takase ,  H Tanaka ,  H Hirota ,  M Hashimoto ,  M Kohsaka
Affiliations
  • 1. Exploratory Research Laboratoires, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
PMID: 1901310 DOI: 10.7164/antibiotics.44.130
Abstract

WF-2421 is a novel Aldose Reductase Inhibitor produced by Humicola grisea. WF-2421 was purified from the culture filtrate by successive ion exchange chromatography and the chemical structure was assigned to be alpha-formamido-5'-(2-formamido-1-hydroxyethyl)- beta,2',6-trihydroxy-3-biphenylpropanoic acid (1) on the basis of spectroscopic evidence. The IC50 value of WF-2421 was 3 x 10(-8) M against partially purified Aldose Reductase of rabbit lens.

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