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Results for "

Heme+oxygenase-1

" in MedChemExpress (MCE) Product Catalog:

38

Inhibitors & Agonists

2

Biochemical Assay Reagents

4

Peptides

9

Natural
Products

2

Recombinant Proteins

2

Isotope-Labeled Compounds

5

Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101193
    Zinc Protoporphyrin
    Maximum Cited Publications
    67 Publications Verification

    Zn(II)-protoporphyrin IX; ZnPP; Zinc Protoporphyrin-9

    		 Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis Cardiovascular Disease Metabolic Disease Cancer
    Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor. Zinc Protoporphyrin regulates expression of HO-1 at the transcriptional level. The effect of Zinc Protoporphyrin on HO-1 expression is controversial.  It was shown to induce HO-1 expression in some cells, but suppress it in others. Zinc Protoporphyrin is used as a screening marker of iron deficiency in vivo. Zinc Protoporphyrin has anti-cancer activity [1] .
    Zinc Protoporphyrin
  • HY-N0643
    Carnosol
    15+ Cited Publications

    		 Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite Cancer
    Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM [1]. Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .
    Carnosol
  • HY-101194
    Tin protoporphyrin IX dichloride
    15+ Cited Publications

    Tin-protoporphyrin IX; Sn-Protoporphyrin; SnPPIX

    		 Reactive Oxygen Species (ROS) Cancer
    Tin protoporphyrin IX dichloride (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin protoporphyrin IX dichloride sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model [1].
    Tin protoporphyrin IX dichloride
  • HY-111798A
    Heme Oxygenase-1-IN-1 hydrochloride
    10+ Cited Publications

    		 Reactive Oxygen Species (ROS) Cancer
    Heme Oxygenase-1-IN-1 (Compound 2) hydrochloride is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 0.25 μM [1].
    Heme Oxygenase-1-IN-1 hydrochloride
  • HY-111798
    Heme Oxygenase-1-IN-1
    10+ Cited Publications

    		 Reactive Oxygen Species (ROS) Cancer
    Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC50 of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research [1].
    Heme Oxygenase-1-IN-1
  • HY-134608
    Cobalt protoporphyrin IX

    Co-PPIX

    		 Reactive Oxygen Species (ROS) Influenza Virus Infection
    Cobalt protoporphyrin IX (Co-PPIX) is a potent and specific heme oxygenase-1 (HO-1) inducer. Cobalt protoporphyrin IX exhibits broad-spectrum antiviral activities against Influenza A virus (IAV) [1].
    Cobalt protoporphyrin IX
  • HY-W013812
    Ethyl linoleate

    Linoleic Acid ethyl ester; Mandenol

    		 Tyrosinase Akt GSK-3 β-catenin Biochemical Assay Reagents NF-κB Heme Oxygenase (HO) Cardiovascular Disease Inflammation/Immunology
    Ethyl linoleate (Linoleic Acid ethyl ester) is an orally active unsaturated fatty acid. Ethyl linoleate inhibits the Akt/GSK3β/β-catenin signaling pathway and the activation of NF-κB. Ethyl linoleate induces heme oxygenase-1 and inhibits tyrosinase. Ethyl linoleate has whitening and anti-inflammatory effects. Ethyl linoleate promotes compound absorption. Ethyl linoleate has a significant influence on atherosclerosis. Ethyl linoleate is used in the research of inflammatory diseases. Ethyl linoleate can be used in cosmetics [1]
    Ethyl linoleate
  • HY-N0061
    Ethyl ferulate
    3 Publications Verification

    		 Reactive Oxygen Species (ROS) Neurological Disease
    Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from Rhizoma Chuanxiong, induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress [1]. Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity .
    Ethyl ferulate
  • HY-B2184
    Sofalcone
    2 Publications Verification

    		 Autophagy Bacterial Infection Inflammation/Immunology
    Sofalcone, a gastric antiulcer agent, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
    Sofalcone
  • HY-B1817A
    Zinc acetate, 99.99% trace metals basis

    Zinc(II) acetate, 99.99% trace metals basis

    		 CDK Heme Oxygenase (HO) Apoptosis Others
    Zinc (Zinc (II)) acetate, 99.99% trace metals basis is a heme oxygenase 1 (HO-1) activator and apoptosis inducer with cytotoxic and anticancer activities. Zinc acetate, 99.99% trace metals basis enhances HO-1 expression, alters the microRNA profile, and increases the level of caspase-cleaved cytokeratin 18. Zinc acetate, 99.99% trace metals basis also regulates the expression of Cdk2/cyclin E and interferes with cell cycle progression. Zinc acetate, 99.99% trace metals basis effectively inhibits cancer cell proliferation and induces their rapid death, with no significant cytotoxicity to non-tumor tissues. Zinc acetate, 99.99% trace metals basis has been widely used in studies related to hepatocellular carcinoma, prostate cancer, and other conditions [1] .
    Zinc acetate, 99.99% trace metals basis
  • HY-N2535
    Coniferaldehyde
    1 Publications Verification

    4-Hydroxy-3-methoxycinnamaldehyde

    		 Keap1-Nrf2 Apoptosis Inflammation/Immunology
    Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities [1].
    Coniferaldehyde
  • HY-147517
    Keap1-Nrf2-IN-9

    		Keap1-Nrf2 Neurological Disease Inflammation/Immunology
    Keap1-Nrf2-IN-9 (Compound 11) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) inhibitor with an IC50 of 0.575 μM. Keap1-Nrf2-IN-9 increases the expression of Nrf2 target genes including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Keap1-Nrf2-IN-9 shows no cytotoxic activity in ARPE19 cells [1].
    Keap1-Nrf2-IN-9
  • HY-34748
    3-Penten-2-one

    Ethylideneacetone; (3Z)-pent-3-en-2-one

    		 Biochemical Assay Reagents Endogenous Metabolite Inflammation/Immunology
    3-Penten-2-one (Ethylideneacetone) inhibits nitric oxide production and inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with Lipopolysaccharides (HY-D1056) (LPS) [1].
    3-Penten-2-one
  • HY-124815
    CP-312

    		Reactive Oxygen Species (ROS) Others
    CP-312 is a potent Heme Oxygenase-1 (HO-1) inducer. CP-312 protects hiPSC-CM viability by targeting the antioxidant response network through induction of HMOX1 expression. CP-312 protects human iPSC-derived cardiomyocytes from oxidative stress [1].
    CP-312
  • HY-162857
    Heme Oxygenase-1-IN-3

    		Heme Oxygenase (HO) Neurological Disease Cancer
    Heme Oxygenase-1-IN-3 (compound 4) is a highly selective heme oxygenase-1 (HO-1) inhibitor (Kd=141 nM) that can be used in the research of cancer and neurodegenerative diseases [1].
    Heme Oxygenase-1-IN-3
  • HY-106359A
    Delmitide acetate

    RDP-58 acetate

    		 TNF Receptor IFNAR Reactive Oxygen Species (ROS) Cancer
    Delmitide (RDP58) acetate is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide acetate inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide acetate can be used for the research of ulcerative colitis [1] .
    Delmitide acetate
  • HY-106359
    Delmitide

    RDP-58

    		 TNF Receptor IFNAR Reactive Oxygen Species (ROS) Infection Inflammation/Immunology Cancer
    Delmitide (RDP58) is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide inhibits production of TNF-α, IFN-γ, and interleukin (IL)-12, and up-regulates heme oxygenase 1 activity. Delmitide can be used for the research of ulcerative colitis [1] .
    Delmitide
  • HY-101193R
    Zinc Protoporphyrin (Standard)

    Zn(II)-protoporphyrin IX (Standard); ZnPP (Standard); Zinc Protoporphyrin-9 (Standard)

    		 Reference Standards Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis Cardiovascular Disease Metabolic Disease Cancer
    Zinc Protoporphyrin (Standard) is the analytical standard of Zinc Protoporphyrin. This product is intended for research and analytical applications. Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2 [1]. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration . Zinc Protoporphyrin has anti-cancer activity .
    Zinc Protoporphyrin (Standard)
  • HY-115713
    Heme Oxygenase-1-IN-2

    		Reactive Oxygen Species (ROS) Cancer
    Heme Oxygenase-1-IN-2 is a novel heme oxygenase-1 inhibitor (IC50 = 0.95 μM) with potent in vitro antiproliferative activity.
    Heme Oxygenase-1-IN-2
  • HY-161601
    Ferroptosis inducer-2

    		Ferroptosis Reactive Oxygen Species (ROS) Cancer
    Ferroptosis inducer-2 (Compound 24) is an inducer for heme oxygenase-1 (HO-1). Ferroptosis inducer-2 exhibits anticancer activity against triple-negative breast cancer (TNBC) cells through induction of ferroptosis [1].
    Ferroptosis inducer-2
  • HY-175660
    KCL-HO-1i

    		Heme Oxygenase (HO) Cancer
    KCL-HO-1i is an orally active heme oxygenase-1 (HO-1) inhibitor (rat HO-1: IC50 = 123 nM) and human HO-1: IC50 = 128 nM). KCL-HO-1i targets immunosuppressive LYVE-1 + perivascular tumor-associated macrophages (PvTAMs) in the tumor microenvironment (TME), reduces PvTAM-mediated immune exclusion. KCL-HO-1i demonstrates synergistic anti-tumor efficacy with chemotherapy in MMTV-PyMT spontaneous breast cancer mice or C57Bl/6 mice bearing subcutaneous MN-MCA1 sarcomas. KCL-HO-1i can be used for the study of cancer [1].
    KCL-HO-1i
  • HY-N0643R
    Carnosol (Standard)

    		Reference Standards Ribosomal S6 Kinase (RSK) Keap1-Nrf2 Endogenous Metabolite Cancer
    Carnosol (Standard) is the analytical standard of Carnosol. This product is intended for research and analytical applications. Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM [1]. Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of heme oxygenase 1 (HMOX1) .
    Carnosol (Standard)
  • HY-W478741
    Pyrraline

    		Endogenous Metabolite Keap1-Nrf2 NF-κB Metabolic Disease Cancer
    Pyrraline is an Nrf2 pathway activator with antioxidant and anti-inflammatory effects. Pyrraline upregulates antioxidant enzymes such as NAD(P)H dehydrogenase (NQO1) and heme oxygenase-1 (HO-1) via antioxidant response element (ARE) activation, while inhibiting NFκB-mediated inflammation. Pyrraline is promising for research of metabolic disorders (such as diabetic nephropathy) and cancers [1] .
    Pyrraline
  • HY-170867
    Nrf2/HO-1 activator 3

    		Keap1-Nrf2 Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Cardiovascular Disease
    Nrf2/HO-1 activator 3 (Compound C3a) is the activator for Nrf2 signaling pathway that promotes the Nrf2 translocation into nuclei and upregulates the expression of heme oxygenase-1 HO-1. Nrf2/HO-1 activator 3 inhibits the overespression of ROS and MDA in H2O2- or glucose-stimulated H9c2 cardiomyocytes, inhibits the cell viability and colony formation, thereby exhibiting antioxidant efficacy [1].
    Nrf2/HO-1 activator 3
  • HY-118487A
    OB-24 free base

    		Endogenous Metabolite Cancer
    OB-24 free base is a compound that potently and selectively inhibits heme oxygenase 1 (HO-1) and has the potential to inhibit advanced prostate cancer. OB-24 significantly reduces protein carbonylation and the formation of reactive oxygen species by selectively inhibiting HO-1 activity in prostate cancer cells. OB-24 significantly inhibited cell proliferation in vitro and inhibited tumor growth and lymph node and lung metastasis in vivo. OB-24 exhibits powerful synergy when used in combination with Taxol [1].
    OB-24 free base
  • HY-P11124
    MGF24

    		Apoptosis PKC Keap1-Nrf2 Heme Oxygenase (HO) Drug Derivative Neurological Disease
    MGF24 is a modified protease-resistant MGF derivative. MGF24 protects dopaminergic neurons from 6-Hydroxydopamine (6-OHDA) (HY-113028)-induced apoptosis by inducing Heme oxygenase-1 (HO-1). MGF24 activates PKC-ε, which in turn activates Nrf2, up-regulating HO-1. MGF24 has neuroprotective activity and reduces myocardial infarct size in sheep models of myocardial ischemia. MGF24 can be used for neurological diseases like stroke, nerve injury and amyotrophic lateral sclerosis research [1].
    MGF24
  • HY-153020
    HIF-PHD-IN-3

    		Reactive Oxygen Species (ROS) Cardiovascular Disease
    HIF-PHD-IN-3 (compound 4) is a potent hiPSC-CM cardioprotective scaffold. HIF-PHD-IN-3 can induce upregulation of heme oxygenase-1 [1].
    HIF-PHD-IN-3
  • HY-B2184S
    Sofalcone-d4

    		Isotope-Labeled Compounds Infection Inflammation/Immunology
    Sofalcone-d4 is deuterated labeled Sofalcone. Sofalcone, a gastric antiulcer agent, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
    Sofalcone-d4
  • HY-B2184R
    Sofalcone (Standard)

    		Reference Standards Autophagy Bacterial Infection Inflammation/Immunology
    Sofalcone (Standard) is the analytical standard of Sofalcone. This product is intended for research and analytical applications. Sofalcone, a gastric antiulcer agent, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
    Sofalcone (Standard)
  • HY-W424839
    Probucol dithiobisphenol

    DTBP

    		 Heme Oxygenase (HO) Cardiovascular Disease
    Probucol dithiobisphenol (DTBP) is the derivative of Probucol (HY-B0388). Probucol dithiobisphenol induces the production of heme oxygenase 1 (HO-1), and exhibits antioxidant activity. Probucol dithiobisphenol inhibits atherosclerotic lesions in Apoe −/− mice aorta, promotes re-endothelialization of aorta and inhibits restenosis in rabbit arterial injury models. Probucol dithiobisphenol is orally active [1].
    Probucol dithiobisphenol
  • HY-124815R
    CP-312 (Standard)

    		Reactive Oxygen Species (ROS) Others
    CP-312 (Standard) is the analytical standard of CP-312. This product is intended for research and analytical applications. CP-312 is a potent Heme Oxygenase-1 (HO-1) inducer. CP-312 protects hiPSC-CM viability by targeting the antioxidant response network through induction of HMOX1 expression. CP-312 protects human iPSC-derived cardiomyocytes from oxidative stress [1].
    CP-312 (Standard)
  • HY-N0761AS
    trans-Isoferulic acid-d3

    		Prostaglandin Receptor NO Synthase Inflammation/Immunology
    trans-Isoferulic acid-d3 is the deuterium labeled trans-Isoferulic acid [1]. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity .trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1) .
    trans-Isoferulic acid-d3
  • HY-N2535R
    Coniferaldehyde (Standard)

    4-Hydroxy-3-methoxycinnamaldehyde (Standard)

    		 Reference Standards Keap1-Nrf2 Apoptosis Inflammation/Immunology
    Coniferaldehyde (Standard) is the analytical standard of Coniferaldehyde. This product is intended for research and analytical applications. Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities [1].
    Coniferaldehyde (Standard)
  • HY-N0761AR
    trans-Isoferulic acid (Standard)

    trans-3-Hydroxy-4-methoxycinnamic acid (Standard)

    		 Reference Standards NO Synthase Prostaglandin Receptor Inflammation/Immunology
    trans-Isoferulic acid (Standard) is the analytical standard of trans-Isoferulic acid. This product is intended for research and analytical applications. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity [1].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1) .
    trans-Isoferulic acid (Standard)
  • HY-120251A
    Leteprinim potassium

    AIT-082

    		 Reactive Oxygen Species (ROS) Neurological Disease
    Leteprinim potassium (AIT-082), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim potassium is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim potassium reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim potassium increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species [1] .
    Leteprinim potassium
  • HY-120251
    Leteprinim

    AIT-082 free acid

    		 Reactive Oxygen Species (ROS) Neurological Disease
    Leteprinim (AIT-082 free acid), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim is a hypoxanthine derivative neurotrophic agent. Leteprinim can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species [1] .
    Leteprinim
  • HY-112749B
    (3S,4R)-ME-344

    		Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Mitochondrial Metabolism Cancer
    (3S,4R)-ME-344 is the (3S,4R)-enantiomer of ME-344 (HY-112749). ME-344 is a mitochondrial Heme oxygenase 1 (HO-1) inhibitor. ME-344 specifically binds and alters HO-1 structure, and increases HO-1 translocation from the rough endoplasmic reticulum to mitochondria, but only in drug-sensitive cells (such as H460 and SHP-77 cells). ME-344 decreases mitochondrial ATP production and induces ROS, with subsequent disruption of redox homeostasis and mitochondrial function. ME-344 has significant antitumor activity, and can be used for cancers like breast cancer research [1].
    (3S,4R)-ME-344
  • HY-P11589
    PIISVYWK

    		PPAR Reactive Oxygen Species (ROS) Keap1-Nrf2 Metabolic Disease
    PIISVYWK is an orally active PPARγ Inhibitor, heme oxygenase-1 Activator, and Nrf2 Activator. PIISVYWK mediates activity via the HO-1/Nrf2 pathway, ameliorates oxidative stress, reduces inflammation, and mediates anti-obesity activity. PIISVYWK can be used for the research of obesity [1].
    PIISVYWK

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