2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. CP-312

CP-312 is a potent Heme Oxygenase-1 (HO-1) inducer. CP-312 protects hiPSC-CM viability by targeting the antioxidant response network through induction of HMOX1 expression. CP-312 protects human iPSC-derived cardiomyocytes from oxidative stress.

For research use only. We do not sell to patients.

CP-312 Chemical Structure

CP-312 Chemical Structure

CAS No. : 895470-67-4

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5 mg USD 130 In-stock
10 mg USD 195 In-stock
25 mg USD 350 In-stock
50 mg USD 520 In-stock
100 mg USD 730 In-stock
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Based on 1 publication(s) in Google Scholar

CP-312 Related Antibodies

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Description

CP-312 is a potent Heme Oxygenase-1 (HO-1) inducer. CP-312 protects hiPSC-CM viability by targeting the antioxidant response network through induction of HMOX1 expression. CP-312 protects human iPSC-derived cardiomyocytes from oxidative stress[1].

In Vitro

CP-312 (10 µM; 2 h) exhibits good potency in protecting hiPSC-CMs from acute peroxide-induced cell death with EC50 = 6.7 µM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CP-312 Related Antibodies
Molecular Weight

361.87

Formula

C16H12ClN3OS2
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

O=C(NC1=NC(C2=NC=CC=C2)=CS1)CSC3=CC=C(Cl)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (345.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7634 mL 13.8171 mL 27.6342 mL
5 mM 0.5527 mL 2.7634 mL 5.5268 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7634 mL 13.8171 mL 27.6342 mL 69.0856 mL
5 mM 0.5527 mL 2.7634 mL 5.5268 mL 13.8171 mL
10 mM 0.2763 mL 1.3817 mL 2.7634 mL 6.9086 mL
15 mM 0.1842 mL 0.9211 mL 1.8423 mL 4.6057 mL
20 mM 0.1382 mL 0.6909 mL 1.3817 mL 3.4543 mL
25 mM 0.1105 mL 0.5527 mL 1.1054 mL 2.7634 mL
30 mM 0.0921 mL 0.4606 mL 0.9211 mL 2.3029 mL
40 mM 0.0691 mL 0.3454 mL 0.6909 mL 1.7271 mL
50 mM 0.0553 mL 0.2763 mL 0.5527 mL 1.3817 mL
60 mM 0.0461 mL 0.2303 mL 0.4606 mL 1.1514 mL
80 mM 0.0345 mL 0.1727 mL 0.3454 mL 0.8636 mL
100 mM 0.0276 mL 0.1382 mL 0.2763 mL 0.6909 mL
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CP-312 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-312895470-67-4CP312CP 312Reactive Oxygen SpeciesantioxidantHMOX1iPSCcardiomyocytesoxidative stressInhibitorinhibitorinhibit

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