Zinc acetate, 99.99% trace metals basis (Synonyms: Zinc(II) acetate, 99.99% trace metals basis)

Cat. No.: HY-B1817A Purity: 99.99%: Data Sheet
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Zinc (Zinc (II)) acetate, 99.99% trace metals basis is a heme oxygenase 1 (HO-1) activator and apoptosis inducer with cytotoxic and anticancer activities. Zinc acetate, 99.99% trace metals basis enhances HO-1 expression, alters the microRNA profile, and increases the level of caspase-cleaved cytokeratin 18. Zinc acetate, 99.99% trace metals basis also regulates the expression of Cdk2/cyclin E and interferes with cell cycle progression. Zinc acetate, 99.99% trace metals basis effectively inhibits cancer cell proliferation and induces their rapid death, with no significant cytotoxicity to non-tumor tissues. Zinc acetate, 99.99% trace metals basis has been widely used in studies related to hepatocellular carcinoma, prostate cancer, and other conditions.

For research use only. We do not sell to patients.

Zinc acetate, 99.99% trace metals basis Chemical Structure

CAS No. : 557-34-6

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HO-1 HO-2

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Zinc acetate, 99.99% trace metals basis (100-800 μM; 4-24 h) induces rapid, dose-dependent cytotoxicity in PC3, DU145 and LNCaP prostate cancer cell lines^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	PC3, DU145, LNCaP
Concentration:	100-800 μM
Incubation Time:	4-24 h; 18 h; duration not specified (prolonged exposure)
Result:	Induced dose-dependent cytotoxicity across all three cell lines. Killed ~80% of the cell population at 300-400 μM within 18 hours. Caused 50% cell death by 6 hours and >95% cell death by 24 hours at 400 μM across all cell lines. Reduced the EC₅₀ by approximately 90 minutes when dose was doubled to 800 μM. Halted cellular proliferation with prolonged exposure to 100 μM, with the number of cells remaining constant over time.

In Vivo

Zinc acetate, 99.99% trace metals basis (3 mM; i.t.; every 48 hours; 14 days) halts PC3 prostate cancer xenograft growth and maintains 80% mouse survival at 8 weeks, with no detectable systemic toxicity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NOD/SCID mice with Prostate cancer (8-week-old male; subcutaneous xenograft model)^[2]
Dosage:	3 mM
Administration:	i.t.; every 48 hours; 14 days
Result:	Halted aggressive growth of PC3 xenografts, with growth arrest persisting after treatment termination on day 14. Reached a tumor volume of ~1000 mm³ by day 20, compared to ~2250 mm³ in control tumors, with statistically significant differences observed from day 16 onward. Increased zinc levels within tumor xenografts substantially, with no significant accumulation in brain, heart, kidney, or liver tissue. Showed no tissue toxicity via post-mortem histological analysis, and caused no animal deaths during the treatment protocol. Maintained 80% of treated mice alive 8 weeks after treatment initiation, while all control mice succumbed to tumor burden within the same period, with statistically significant difference.

Molecular Weight

183.47

Formula

(CH₃CO₂)₂Zn

CAS No.

557-34-6

Appearance

Solid

Color

White to off-white

SMILES

C[Zn]C.O=C=O.O=C=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (545.05 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.4505 mL	27.2524 mL	54.5048 mL
5 mM	1.0901 mL	5.4505 mL	10.9010 mL
10 mM	0.5450 mL	2.7252 mL	5.4505 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.99%

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Data Sheet (275 KB) SDS (640 KB)

COA (245 KB)

Handling Instructions (2659 KB)

References

[1]. Hashimoto R, et al. Antitumor Effect of Zinc Acetate in Hepatocellular Carcinoma Cell Lines via the Induction of Apoptosis. J Nutr Sci Vitaminol (Tokyo). 2022;68(4):303-311. [Content Brief]

[2]. Shah MR, et al. Direct intra-tumoral injection of zinc-acetate halts tumor growth in a xenograft model of prostate cancer. J Exp Clin Cancer Res. 2009;28(1):84. Published 2009 Jun 17. [Content Brief]

[3]. Oh S, et al. Effect of ZnO nanoparticle morphology and post-treatment with zinc acetate on buffer layer in inverted organic photovoltaic cells[J]. Solar Energy, 2015, 114: 32-38.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.4505 mL	27.2524 mL	54.5048 mL	136.2621 mL
	5 mM	1.0901 mL	5.4505 mL	10.9010 mL	27.2524 mL
	10 mM	0.5450 mL	2.7252 mL	5.4505 mL	13.6262 mL
	15 mM	0.3634 mL	1.8168 mL	3.6337 mL	9.0841 mL
	20 mM	0.2725 mL	1.3626 mL	2.7252 mL	6.8131 mL
	25 mM	0.2180 mL	1.0901 mL	2.1802 mL	5.4505 mL
	30 mM	0.1817 mL	0.9084 mL	1.8168 mL	4.5421 mL
	40 mM	0.1363 mL	0.6813 mL	1.3626 mL	3.4066 mL
	50 mM	0.1090 mL	0.5450 mL	1.0901 mL	2.7252 mL
	60 mM	0.0908 mL	0.4542 mL	0.9084 mL	2.2710 mL
	80 mM	0.0681 mL	0.3407 mL	0.6813 mL	1.7033 mL
	100 mM	0.0545 mL	0.2725 mL	0.5450 mL	1.3626 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Zinc acetate, 99.99% trace metals basis Related Classifications

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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Zinc acetate, 99.99% trace metals basis (Synonyms: Zinc(II) acetate, 99.99% trace metals basis)

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