Zinc acetate, 99.99% trace metals basis
Based on 1 Customer Validation
Zinc (Zinc (II)) acetate, 99.99% trace metals basis is a heme oxygenase 1 (HO-1) activator and apoptosis inducer with cytotoxic and anticancer activities. Zinc acetate, 99.99% trace metals basis enhances HO-1 expression, alters the microRNA profile, and increases the level of caspase-cleaved cytokeratin 18. Zinc acetate, 99.99% trace metals basis also regulates the expression of Cdk2/cyclin E and interferes with cell cycle progression. Zinc acetate, 99.99% trace metals basis effectively inhibits cancer cell proliferation and induces their rapid death, with no significant cytotoxicity to non-tumor tissues. Zinc acetate, 99.99% trace metals basis has been widely used in studies related to hepatocellular carcinoma, prostate cancer, and other conditions.
For research use only. We do not sell to patients.
- Purity: 99.99%
- CAS No.: 557-34-6
- Formula: (CH3CO2)2Zn
- Molecular Weight:183.47
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Apoptosis Compound Library
HY-L003
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Metabolism/Protease Compound Library
HY-L012
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Anti-Aging Compound Library
HY-L034
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Anti-Blood Cancer Compound Library
HY-L079
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Anti-Obesity Compound Library
HY-L087
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Anti-Liver Cancer Compound Library
HY-L101
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Anti-Prostate Cancer Compound Library
HY-L124
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Mitochondrial Protection Compound Library
HY-L144
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Cell Death Library
HY-L162
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Anti-Hematopathy Compound Library
HY-L171
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MCE Bioactive Compound Library
HY-L001V
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Protein Kinase Compound Library
HY-L196
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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Cell Proliferation Compound Library
HY-L201
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
Zinc acetate, 99.99% trace metals basis (100-800 μM; 4-24 h) induces rapid, dose-dependent cytotoxicity in PC3, DU145 and LNCaP prostate cancer cell lines[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC3, DU145, LNCaP
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Concentration:100-800 μM
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Incubation Time:4-24 h; 18 h; duration not specified (prolonged exposure)
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Result:Induced dose-dependent cytotoxicity across all three cell lines.
Killed ~80% of the cell population at 300-400 μM within 18 hours.
Caused 50% cell death by 6 hours and >95% cell death by 24 hours at 400 μM across all cell lines.
Reduced the EC50 by approximately 90 minutes when dose was doubled to 800 μM.
Halted cellular proliferation with prolonged exposure to 100 μM, with the number of cells remaining constant over time.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD/SCID mice with Prostate cancer (8-week-old male; subcutaneous xenograft model)[2]
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Dosage:3 mM
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Administration:i.t.; every 48 hours; 14 days
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Result:Halted aggressive growth of PC3 xenografts, with growth arrest persisting after treatment termination on day 14.
Reached a tumor volume of ~1000 mm3 by day 20, compared to ~2250 mm3 in control tumors, with statistically significant differences observed from day 16 onward.
Increased zinc levels within tumor xenografts substantially, with no significant accumulation in brain, heart, kidney, or liver tissue.
Showed no tissue toxicity via post-mortem histological analysis, and caused no animal deaths during the treatment protocol.
Maintained 80% of treated mice alive 8 weeks after treatment initiation, while all control mice succumbed to tumor burden within the same period, with statistically significant difference.
Chemical Information
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CAS No. 557-34-6
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Appearance Solid
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Molecular Weight 183.47
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Formula (CH3CO2)2Zn
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Color White to off-white
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SMILES
C[Zn]C.O=C=O.O=C=O
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Synonyms
Zinc(II) acetate, 99.99% trace metals basis
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
H2O : 100 mg/mL (545.05 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (640 KB)
- English - EN (640 KB)
- Français - FR (640 KB)
- Deutsch - DE (640 KB)
- Norwegian - NO (640 KB)
- Español - ES (640 KB)
- Swedish - SV (640 KB)
- Italian - IT (640 KB)
- Korean - KR (640 KB)
- Portuguese - PT (640 KB)
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Handling Instructions (2659 KB)
References
[1]. Hashimoto R, et al. Antitumor Effect of Zinc Acetate in Hepatocellular Carcinoma Cell Lines via the Induction of Apoptosis. J Nutr Sci Vitaminol (Tokyo). 2022;68(4):303-311. [Content Brief]
[2]. Shah MR, et al. Direct intra-tumoral injection of zinc-acetate halts tumor growth in a xenograft model of prostate cancer. J Exp Clin Cancer Res. 2009;28(1):84. Published 2009 Jun 17. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.4505 mL | 27.2524 mL | 54.5048 mL | 136.2621 mL |
| 5 mM | 1.0901 mL | 5.4505 mL | 10.9010 mL | 27.2524 mL | |
| 10 mM | 0.5450 mL | 2.7252 mL | 5.4505 mL | 13.6262 mL | |
| 15 mM | 0.3634 mL | 1.8168 mL | 3.6337 mL | 9.0841 mL | |
| 20 mM | 0.2725 mL | 1.3626 mL | 2.7252 mL | 6.8131 mL | |
| 25 mM | 0.2180 mL | 1.0901 mL | 2.1802 mL | 5.4505 mL | |
| 30 mM | 0.1817 mL | 0.9084 mL | 1.8168 mL | 4.5421 mL | |
| 40 mM | 0.1363 mL | 0.6813 mL | 1.3626 mL | 3.4066 mL | |
| 50 mM | 0.1090 mL | 0.5450 mL | 1.0901 mL | 2.7252 mL | |
| 60 mM | 0.0908 mL | 0.4542 mL | 0.9084 mL | 2.2710 mL | |
| 80 mM | 0.0681 mL | 0.3407 mL | 0.6813 mL | 1.7033 mL | |
| 100 mM | 0.0545 mL | 0.2725 mL | 0.5450 mL | 1.3626 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Zinc acetate, 99.99% trace metals basis Related Classifications
HY-B1817A Related Classifications
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- Zinc acetate, 99.99% trace metals basis
- 557-34-6
- Zinc(II) acetate, 99.99% trace metals basis
- CDK
- Heme Oxygenase (HO)
- Apoptosis
- prostate cancer
- apoptosis
- DU145
- PC3
- microRNA profile
- hepatocellular carcinoma
- cancer cells
- heme oxygenase-1 (HO-1)
- caspase-cleaved cytokeratin 18
- cell cycle progression
- Inhibitor
- inhibitor
- inhibit