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Theaflavin 3,3'-digallate (TF-3) is a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM. Theaflavin 3,3'-digallat directly binds to ZIKVpro (Kd=8.86 µM) and inhibits ZIKV replication. Theaflavin 3,3'-digallat inhibits the activity of gp41 and NS2B-3 protease and has antiviral activity against HSV and HIV-1 . Theaflavin 3,3'-digallate, the typical pigment in black tea, is a potent antitumor agent .
TF Human Pre-designed siRNA Set A contains three designed siRNAs for TF gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Scorpion toxin Tf2 is a β-scorpion toxin, which is firstly identified in the venom of the Brazilian scorpion Tityus fasciolatus. Scorpion toxin Tf2 is a Nav1.3 activator, which is a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Scorpion toxin Tf2 enhances hNav1.3 activation voltage and opens the channel at resting membrane potentials .
Tisotumab vedotin is an antibody-drug conjugate (ADC) targeting tissue factor (TF). Tisotumab vedotin consists of a fully human monoclonal antibody to tissue factor (TF-011) conjugated to Monomethyl Auristatin E (MMAE). Tisotumab vedotin has good antitumor activity and can be used in the research of advanced or metastatic solid tumors .
JAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively. JAK3-IN-14 shows inhibitory of IL-4 and IL-3 induced TF-1 cell proliferation, with IC50 values of 600 and 500 nM, respectively .
Tisotumab (Anti-Human F3 Recombinant Antibody) is a human IgG1 monoclonal antibody targets tissue factor (TF). Tisotumab can be used for the research of solid tumors .
Rademikibart (CBP-201) is a human monoclonal antibody targeting IL-4Rα with a KD of 20.7 pM when binding to human IL-4Rα epitopes. Rademikibart does not bind to IL-4Rα from other species. Rademikibart inhibits IL-4 and IL-13-mediated STAT6 signaling, TF-1 cell proliferation and TARC production in PBMCs. Rademikibart has the potential for moderate-to-severe Th2 inflammatory diseases research .
SHP099 hydrochloride is an allosteric SHP2 inhibitor, with IC50s of 0.690, 1.241, 0.416, 1.968, 2.896 μM for SHP2, SHP2 D61Y, SHP2E69K, SHP2 A72V, SHP2 E76K. SHP099 hydrochloride inhibits cancer cell growth, such as MV4-11 and TF-1 cell (IC50: 0.32 and 1.73 μM). SHP099 hydrochloride inhibits RAS-ERK signaling and inhibit tumor growth .
IDH2 R140Q-IN-2 (compound 36) is an an orally active IDH2 R140Q inhibitor (IC50: 29 nM). IDH2 R140Q-IN-2 reduces D2HG production in TF-1 cell lines expressing mutant IDH2 R140Q (IC50: 10 nM). IDH2 R140Q-IN-2 suppresses D2HG levels in tumor tissue. IDH2 R140Q-IN-2 can be used for research of acute myeloid leukemia (AML) .
Fluridone is a herbicide, particularly to eliminate aquatic plant growth in water reservoirs and irrigation channels. Fluridone is a potent Abscisic acid (ABA) biosynthesis inhibitor, and has anti-inflammatory effects .
ARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.
ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.
Scorpion toxin Tf2 is a β-scorpion toxin, which is firstly identified in the venom of the Brazilian scorpion Tityus fasciolatus. Scorpion toxin Tf2 is a Nav1.3 activator, which is a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Scorpion toxin Tf2 enhances hNav1.3 activation voltage and opens the channel at resting membrane potentials .
Tisotumab (Anti-Human F3 Recombinant Antibody) is a human IgG1 monoclonal antibody targets tissue factor (TF). Tisotumab can be used for the research of solid tumors .
Rademikibart (CBP-201) is a human monoclonal antibody targeting IL-4Rα with a KD of 20.7 pM when binding to human IL-4Rα epitopes. Rademikibart does not bind to IL-4Rα from other species. Rademikibart inhibits IL-4 and IL-13-mediated STAT6 signaling, TF-1 cell proliferation and TARC production in PBMCs. Rademikibart has the potential for moderate-to-severe Th2 inflammatory diseases research .
Tissue Factor Protein, Human (HEK293, Fc) is a recombinant human CD142 expressed in HEK 293 cells with a His tag at the N-terminus. Coagulation Factor III/CD142 Protein is a principal regulator of oncogenic neoangiogenesis and controls therefore the cancerous process.
F3 Protein, a cell surface receptor, plays a significant role in regulating blood coagulation and promoting cell adhesion. Dysregulation of F3 Protein has been associated with various disorders, including thrombosis and cancer. Targeting F3 Protein may offer potential therapeutic interventions in these conditions by inhibiting blood clot formation and preventing tumor cell adhesion and metastasis. Tissue Factor Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Tissue Factor protein, expressed by HEK293 , with C-His labeled tag. The total length of Tissue Factor Protein, Cynomolgus (HEK293, His) is 220 a.a., with molecular weight of approximately 34-50 kDa.
Coagulation Factor III (F3), or Tissue Factor (TF), initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex critically activates factors IX or X through limited proteolysis, initiating the coagulation cascade on the cell surface. F3's interaction with HSPE, inhibited by heparin, promotes the generation of activated factor X, emphasizing its central role in regulating hemostatic processes. Coagulation Factor III/F3 Protein, Canine (HEK293, His) is the recombinant canine-derived Coagulation Factor III/F3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Coagulation Factor III/F3 Protein, Canine (HEK293, His) is 214 a.a., with molecular weight of 35-45 kDa.
Transferrin is an important iron-binding transport protein that binds two Fe(3+) ions, usually with anions such as bicarbonate. Crucially, it transports iron from the site of absorption and heme degradation to the site of storage and utilization. Transferrin Protein, Pig (HEK293, hFc) is the recombinant pig-derived Transferrin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Transferrin Protein, Pig (HEK293, hFc) is 715 a.a., with molecular weight of 100-110 kDa.
Transferrin is an important iron-binding transport protein that binds two Fe(3+) ions, usually with anions such as bicarbonate. Crucially, it transports iron from the site of absorption and heme degradation to the site of storage and utilization. Transferrin Protein, Pig (HEK293, His) is the recombinant pig-derived Transferrin protein, expressed by HEK293 , with C-His labeled tag. The total length of Transferrin Protein, Pig (HEK293, His) is 694 a.a., with molecular weight of ~80 kDa.
Transferrin is an important iron-binding transport protein that combines two Fe(3+) ions with an anion, usually bicarbonate. Its main function is to transport iron from the site of absorption to the site of storage and utilization. Transferrin Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Transferrin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Transferrin Protein, Mouse (HEK293, Fc) is 697 a.a., with molecular weight of ~102 kDa.
Transferrin is an important iron-binding transport protein that combines two Fe(3+) ions with an anion, usually bicarbonate. Its primary function is to transport iron from the site of absorption and heme degradation to the site of storage and utilization. Transferrin Protein, Rat (HEK293, His) is the recombinant rat-derived Transferrin protein, expressed by HEK293 , with C-His labeled tag. The total length of Transferrin Protein, Rat (HEK293, His) is 679 a.a., with molecular weight of ~89 kDa.
Transferrin is an important iron-binding transport protein that combines two Fe(3+) ions with an anion, usually bicarbonate. Its main function is to transport iron from the site of absorption to the site of storage and utilization. Transferrin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Transferrin protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Transferrin Protein, Mouse (HEK293, His) is 678 a.a., with molecular weight of approximately 85 kDa.
Tissue Factor Protein initiates blood coagulation by binding to coagulation factors. It activates clotting cascades and interacts with cells to promote thrombosis and inflammation. Understanding Tissue Factor Protein's functions is crucial for developing treatments for cardiovascular diseases and blood disorders. Tissue Factor Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived Tissue Factor protein, expressed by HEK293 , with C-His labeled tag. The total length of Tissue Factor Protein, Rabbit (HEK293, His) is 218 a.a., with molecular weight of ~26.4 kDa.
Tissue Factor Protein plays a critical role in blood coagulation. It binds to coagulation factors, activating clotting cascades. Tissue Factor Protein interacts with cells, promoting thrombosis and inflammation. Understanding its functions can aid in developing treatments for blood disorders and cardiovascular diseases. Tissue Factor Protein, Rat (HEK293, His) is the recombinant rat-derived Tissue Factor protein, expressed by HEK293 , with C-His labeled tag. The total length of Tissue Factor Protein, Rat (HEK293, His) is 252 a.a., with molecular weight of 47-52 kDa.
Tissue Factor Protein, Human (HEK293, His) is a recombinant human CD142 expressed in HEK 293 cells with a His tag at the N-terminus. Coagulation Factor III/CD142 Protein is a principal regulator of oncogenic neoangiogenesis and controls therefore the cancerous process.
Transferrin proteins, iron-binding transporters, bind two Fe(3+) ions and an anion, usually bicarbonate. They transport iron from absorption and heme degradation sites to storage and utilization locations. Serum transferrin may impact cell proliferation. In microbial infection, Neisseria species utilize transferrin as an iron source, capturing and extracting iron for their metabolic needs. Transferrin Protein, Human (HEK293, His) is the recombinant human-derived Transferrin protein, expressed by HEK293 , with C-His labeled tag. The total length of Transferrin Protein, Human (HEK293, His) is 679 a.a., with molecular weight of 68-87 kDa.
Trigger protein is essential for protein export, acting as chaperone and peptidyl prolyl cis-trans isomerase. In its chaperone role, it keeps nascent polypeptides in an open conformation, facilitating correct protein folding. Trigger factor Protein, E.coli (P.pastoris, His) is the recombinant E. coli-derived Trigger factor protein, expressed by P. pastoris , with N-His labeled tag. The total length of Trigger factor Protein, E.coli (P.pastoris, His) is 432 a.a., with molecular weight (affected by relative charge) of ~60 KDa.
Tissue factor (TF) initiates blood coagulation by forming a complex with circulating factor VII or VIIa, thus forming the [TF:VIIa] complex. This complex is capable of specific limited proteolysis of factors IX or X and plays a key role in normal hemostasis by initiating the coagulation protease cascade. Tissue Factor Protein, Mouse (HEK293, His) is the recombinant mouse-derived Tissue Factor protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Tissue Factor Protein, Mouse (HEK293, His) is 223 a.a., with molecular weight of 35-42 kDa.
TFIIB protein is a general transcription factor involved in the initiation of RNA polymerase II. TFIIB Protein, Human (GST) is the recombinant human-derived TFIIB protein, expressed by E. coli , with N-GST labeled tag. The total length of TFIIB Protein, Human (GST) is 316 a.a., with molecular weight of ~62.0 kDa.
PDCD5 Protein is implicated in apoptosis, highlighting its potential role in regulating programmed cell death and maintaining cellular homeostasis. Despite this functional attribution, the specific molecular interactions and pathways involving PDCD5 in apoptosis require further exploration for a comprehensive understanding of its significance in cellular fate determination and survival mechanisms. PDCD5 Protein, Human (His) is the recombinant human-derived PDCD5 protein, expressed by E. coli , with N-6*His labeled tag. The total length of PDCD5 Protein, Human (His) is 125 a.a., with molecular weight of ~22 kDa.
The PDCD10 protein is a multifunctional regulator that plays a key role in cell proliferation, apoptosis regulation, and enhanced kinase activity. It is essential for cell migration, Golgi complex assembly and KDR/VEGFR2 signaling stability, affecting embryonic development, cardiovascular development, vasculogenesis, vasculogenesis and hematopoiesis. PDCD10 Protein, Human is the recombinant human-derived PDCD10 protein, expressed by E. coli , with tag free. The total length of PDCD10 Protein, Human is 212 a.a., with molecular weight of ~28.0 kDa.
TRIM24 protein is a multifunctional coactivator that dynamically interacts with nuclear receptors and coactivators to influence target gene transcription. It binds preferentially to unmodified H3K4me0 and acetylated H3K23. TRIM24 Protein, Human (P. pastoris, His) is the recombinant human-derived TRIM24 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of TRIM24 Protein, Human (P. pastoris, His) is 122 a.a., with molecular weight of 16.5 kDa.
Apotransferrin; beta 1 metal binding globulin; serotransferrin; TF
WB, IHC-P, ICC/IF
Human
Transferrin Antibody (YA840) is a non-conjugated and Mouse origined monoclonal antibody about 77 kDa. It can be used for WB,IHC-P,ICC/IF assays in the background of Human.
NF-KB p65 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 60 kDa, targeting to NF-KB p65. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse.
Phospho-NF-KB p65 (Ser536) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 60 kDa, targeting to Phospho-NF-KB p65 (Ser536). It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.
Phospho-NF-KB p65 (Thr254) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 60 kDa, targeting to Phospho-NF-KB p65 (Thr254). It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.
ATF3 Antibody is an unconjugated, approximately 20 kDa, rabbit-derived, anti-ATF3 polyclonal antibody. ATF3 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, and predicted: rat, chicken, dog, cow background without labeling.
NF-KB p100 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 97 kDa, targeting to NF-KB p100. It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.
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