IDH2R140Q-IN-2
IDH2R140Q-IN-2 (compound 36) is an an orally active IDH2R140Q inhibitor (IC50: 29 nM). IDH2R140Q-IN-2 reduces D2HG production in TF-1 cell lines expressing mutant IDH2R140Q (IC50: 10 nM). IDH2R140Q-IN-2 suppresses D2HG levels in tumor tissue. IDH2R140Q-IN-2 can be used for research of acute myeloid leukemia (AML).
For research use only. We do not sell to patients.
- CAS No.: 2749568-16-7
- Formula: C21H18F6N6O
- Molecular Weight:484.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 2749568-16-7
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Molecular Weight 484.40
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Formula C21H18F6N6O
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SMILES
FC(F)(C1=CC(NC2=NC(N3CCC(C3)O)=NC(NC4=CC=CC(C(F)(F)F)=C4)=N2)=CC=C1)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IDH2R140Q-IN-2 Related Classifications
HY-156158 Related Classifications
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