2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. IDH2R140Q-IN-2

IDH2R140Q-IN-2 (compound 36) is an an orally active IDH2R140Q inhibitor (IC50: 29 nM). IDH2R140Q-IN-2 reduces D2HG production in TF-1 cell lines expressing mutant IDH2R140Q (IC50: 10 nM). IDH2R140Q-IN-2 suppresses D2HG levels in tumor tissue. IDH2R140Q-IN-2 can be used for research of acute myeloid leukemia (AML).

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IDH2R140Q-IN-2 Chemical Structure

IDH2R140Q-IN-2 Chemical Structure

CAS No. : 2749568-16-7

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IDH2R140Q-IN-2 Related Antibodies

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Description

IDH2R140Q-IN-2 (compound 36) is an an orally active IDH2R140Q inhibitor (IC50: 29 nM). IDH2R140Q-IN-2 reduces D2HG production in TF-1 cell lines expressing mutant IDH2R140Q (IC50: 10 nM). IDH2R140Q-IN-2 suppresses D2HG levels in tumor tissue. IDH2R140Q-IN-2 can be used for research of acute myeloid leukemia (AML)[1].

Molecular Weight

484.40

Formula

C21H18F6N6O
CAS No.
SMILES

FC(F)(C1=CC(NC2=NC(N3CCC(C3)O)=NC(NC4=CC=CC(C(F)(F)F)=C4)=N2)=CC=C1)F
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Purity & Documentation
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IDH2R140Q-IN-2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IDH2R140Q-IN-22749568-16-7Isocitrate Dehydrogenase (IDH)R140Q mutantleukemiaAMLTF-1 cellInhibitorinhibitorinhibit

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