2749568-16-7
2749568-16-7
Chemical Structure
IDH2R140Q-IN-2
- CAS No.: 2749568-16-7
- Formula:C21H18F6N6O
- Molecular Weight:484.40
InChIKey: LLLRTMHIPPFYSX-UHFFFAOYSA-N
SMILES: FC(F)(C1=CC(NC2=NC(N3CCC(C3)O)=NC(NC4=CC=CC(C(F)(F)F)=C4)=N2)=CC=C1)F
Biological Activity: IDH2R140Q-IN-2 (compound 36) is an an orally active IDH2R140Q inhibitor (IC50: 29 nM). IDH2R140Q-IN-2 reduces D2HG production in TF-1 cell lines expressing mutant IDH2R140Q (IC50: 10 nM). IDH2R140Q-IN-2 suppresses D2HG levels in tumor tissue. IDH2R140Q-IN-2 can be used for research of acute myeloid leukemia (AML)[1].
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IDH2R140Q-IN-2 | IDH2R140Q-IN-2 (compound 36) is an an orally active IDH2R140Q inhibitor (IC50: 29 nM). IDH2R140Q-IN-2 reduces D2HG production in TF-1 cell lines expressing mutant IDH2R140Q (IC50: 10 nM). IDH2R140Q-IN-2 suppresses D2HG levels in tumor tissue. IDH2R140Q-IN-2 can be used for research of acute myeloid leukemia (AML). | |||||||||||||||||||||
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References
Keywords
