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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
34 Results for "
activated RAW 264.7 cells
" in MedChemExpress (MCE) Product Catalog:
Products (34)
34 Results for "activated RAW 264.7 cells" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-N0515
CAS No.: 945619-74-9
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2 Cited Publications
Cat. No.: HY-N0569
CAS No.: 18449-41-7
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Ranunculaceae Coumarins Phenylpropanoids Plants Cimicifuga racemosa (L.) Nutt. Disease Research Fields Inflammation/Immunology
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1 Cited Publications
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T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50=27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s=110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.
Cat. No.: HY-172208
CAS No.: 3118499-89-8
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PROTAC cGAS degrader-1 is a potent and selective cGAS PROTAC degrader, with DC50 values of 0.9 μM and 4.6 μM in THP-1 and RAW 264.7 cells, respectively. PROTAC cGAS degrader-1 induces proteasome-mediated degradation of cGAS, inhibits the cGAS signaling pathway, and attenuates double-stranded DNA-induced activation of cGAS in human and mouse cells. PROTAC cGAS degrader-1 is applicable to research related to ulcerative colitis .
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Quinones Monophenols Anthraquinones Rubiaceae Phenols Plants Damnacanthus major Sieb. et Zucc.
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Ethyl gentisate (Ethyl 2,5-dihydroxybenzoate) is a dual modulator for cell differentiation, that enhances the osteogenic differentiation of human mesenchymal stem cells (hMSCs) and alkaline phosphatase activity, inhibits RANKL-activated osteoclastogenesis in RAW264.7 cells, and balances the bone remodeling process .
Cat. No.: HY-W753791
CAS No.: 2111-75-3
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(±)-Perillaldehyde has an antidepressant effect by modulating the olfactory nervous system in a mouse model of stress-induced depression. (±)-Perillaldehyde also has anti-inflammatory activity, inducing JNK activation in RAW264.7 cells and inhibiting the expression of TNF-α, with an IC50 of 171.7 μM .
Cat. No.: HY-N0569R
CAS No.: 18449-41-7
Cat. No.: HY-168207
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TH023 is an inhibitor for the TLR4 signaling pathway, that targets especially the formation of TLR4 homodimer. TH023 inhibits secreted embryonic alkaline phosphatase in cell HEK-Blue hTLR4 with an IC50 of 0.354 μM, and inhibits the NO expression in RAW264.7 with an IC50 of 1.61μM. TH023 also inhibits the activation of NF-κB, reduces the nuclear translocation of NF-κB p65. TH023 exhibits anti-inflammatory efficacy in LPS (HY-D1056)-induced mouse acute sepsis model, and ameliorates the mouse lung injury .
Cat. No.: HY-N0515R
CAS No.: 945619-74-9
Cat. No.: HY-118816
CAS No.: 714966-38-8
Synonyms: 11-epi PGF2α-EA; 11β-PGF2α-EA; 11β-Prostamide F2α
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11β-Prostaglandin F2α ethanolamide (11β-PGF2α-EA) is the theoretical hepatic metabolite of PGD2-EA, produced during COX-2 metabolism of the endogenous cannabinoid AEA which is found in brain, liver, and other mammalian tissues.1 AEA can be used directly by COX-2 and specific PG synthase to produce ethanolamide congeners of the classical PGs. PGD2-EA is formed in activated RAW 264.7 cells treated with AEA.
Cat. No.: HY-N4155
CAS No.: 176983-21-4
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Cat. No.: HY-N3211
CAS No.: 80510-09-4
Synonyms: cis-N-(4-Hydroxyphenethyl) ferulamide; cis-N-Feruloyltyramine
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Annona cherimola Mill. Phenols Polyphenols Plants Annonaceae
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Cat. No.: HY-N10114
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Alkaloids Hypecoum erectum L. Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology Papaveraceae
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Cat. No.: HY-N10062
CAS No.: 2923661-84-9
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Cat. No.: HY-161043
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ECDD-S16 is a potent inhibitor of pyroptosis. ECDD-S16 inhibits surface and endosomal TLR ligands activated pyroptosis in Raw264.7 cells .
Cat. No.: HY-176126
CAS No.: 2942231-48-1
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STING agonist-42 (compound 8a) is a potent STING agonist. STING agonist-42 activates STING in THP1 and RAW 264.7 cells with EC50s of 0.06 and 14.15 μM, respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
