SIN 14

SIN 14 (2.5-10 μM, 24 h) can inhibit NO release in LPS-induced RAW 264.7 (IC₅₀ = 4.97 μM), BMDM (IC₅₀ = 3.88 μM), and BV-2 cells (IC₅₀ = 3.88 μM)^[1].
SIN 14 (2.5-10 μM, 24 h) significantly suppresses the release of inflammatory factors, including NO, IL-6, IL-1β, and CCL2, and down-regulates the expression of COX-2 and iNOS upon LPS-induced RAW 264.7 cells^[1].
SIN 14 (50 μM) inhibits inflammatory cells migration and aggregation induced by CuSO4 in Tg (zlyz: EGFP) transgenic zebrafish line^[1].
SIN 14 (10 μM, 24 h) inhibits M1 macrophage polarization while promoting M2 polarization in LPS-induced RAW264.7 cells^[1].
SIN 14 (10 μM, 4 h or 20 min) significantly increases HO-1 stability (4 h) and enhances HO-1 resistance to pronase-induced proteolysis (20 min)^[1].
SIN 14 (2.5-10 μM, 24 h) can inhibit NO production and TNF-α release, and these effects were reduced in HO-1 siRNA-transfected cells^[1].
SIN 14 (10 μM, 24 h) inhibits ROS levels in LPS-induced RAW 264.7 cells by activating HO-1 (detected with the DCFH-DA probe (HY-D0940))^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.