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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

conjugated metabolites

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (1) ADC Payload (1) Amino Acid Derivatives (1) Antibiotic (1) Apoptosis (2) ATP-binding cassette (ABC) transporters (2) Bacterial (1) Biochemical Assay Reagents (1) Cytochrome P450 (2) Drug Derivative (3) Drug Metabolite (19) Drug-Linker Conjugates for ADC (11) Endogenous Metabolite (26) Environmental Pollutants (1) FAAH (2) Isotope-Labeled Compounds (8) Kinesin (1) Microtubule/Tubulin (1) NO Synthase (2) OAT (2) Reference Standards (10) SOD (2)
By Research Areas:	Cancer (21) Cardiovascular Disease (3) Infection (1) Inflammation/Immunology (5) Metabolic Disease (16) Neurological Disease (10)
Click Chemistry:	ADC Synthesis (1) DBCO (1) Azide (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1424

Glycoursodeoxycholic acid 3 Publications Verification GUDCA; Ursodeoxycholylglycine	Endogenous Metabolite	Neurological Disease
Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.

HY-116374

Glycolithocholic acid 2 Publications Verification Lithocholylglycine	Endogenous Metabolite	Inflammation/Immunology
Glycolithocholic acid (Lithocholylglycine), an endogenous metabolite, is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) .

HY-126995

Glycohyodeoxycholic acid	Endogenous Metabolite	Metabolic Disease
Glycohyodeoxycholic acid is a glycine-conjugated bile acid and also a metabolite of Hyodeoxycholic acid (HY-N0169). The serum level of Glycohyodeoxycholic acid is negatively correlated with the severity of non-alcoholic fatty liver disease. Glycohyodeoxycholic acid can be used in research related to non-alcoholic fatty liver disease .

HY-125934

Allocholic acid	Endogenous Metabolite	Cancer
Allocholic acid is a typically fetal bile acid found in vertebrates and reappears during liver regeneration and carcinogenesis, besides it is also a conjugate acid of allocholate and an isomer of cholic acid. Allocholic acid is a potent and specific stimulant of the adult olfactory system, it has a role as a marine metabolite, a rat metabolite and a human metabolite .

HY-126687

Mal-PEG4-VC-PAB-DMEA-PNU-159682	Drug-Linker Conjugates for ADC	Cancer
Mal-PEG4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker Mal-PEG4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682 .

HY-101982

Lys-SMCC-DM1 1 Publications Verification Lys-Nε-MCC-DM1	Drug-Linker Conjugates for ADC	Cancer
Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a agent-linker conjugates for ADC that can inhibit tubulin polymerization. Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is a HER2-targeting ADC with a tubulin polymerization inhibitor DM1. Lys-SMCC-DM1 can be used in the research of breast cancer .

HY-77641

Cinnamoylglycine	Endogenous Metabolite	Metabolic Disease
Cinnamoylglycine is a human urinary metabolite and PPG analog. Cinnamoylglycine is a conjugate of cinnamic acid and glycine. Cinnamoylglycine is used as a urine marker. Cinnamoylglycine can be used in adipogenic differentiation studies .

HY-153013

SN38-COOH	Drug-Linker Conjugates for ADC	Cancer
SN38-COOH is used for the synthesis of antibody-drug conjugates (ADCs). SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis .

HY-137522

Zidovudine O-β-D-glucuronide sodium 3'-Azido-3'-deoxythymidine β-D-glucuronide sodium	Drug Metabolite	Others
Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .

HY-W008646

7,8-Dihydro-L-biopterin 1 Publications Verification	SOD Apoptosis NO Synthase	Cardiovascular Disease Neurological Disease
7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. 7,8-Dihydro-L-biopterin is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. 7,8-Dihydro-L-biopterin promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. 7,8-Dihydro-L-biopterin is sensitive to the inhibitory effect of SOD, and it can be applied to research related to salt-sensitive hypertension, moderate to severe traumatic brain injury, and neurodegenerative diseases .

HY-139909A

CL2E-SN38 TFA 1 Publications Verification	Drug-Linker Conjugates for ADC	Cancer
CL2E-SN-38 TFA, a highly releasable and structurally stable antibody-SN-38-conjugate, is a part of the antibody drug conjugate (ADC). SN-38, the active metabolite of Irinotecan from camptothecins, is an Topoisomerase I inhibitor .

HY-136170

MC-SN38 2 Publications Verification	Drug-Linker Conjugates for ADC	Cancer
MC-SN38 is a agent-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody agent conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks .

HY-W041019

5-Hydroxytryptophol 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
5-Hydroxytryptophol is a mammalian serotonin metabolite that can be used as a sensitive biomarker for recent alcohol intake. 5-Hydroxytryptophol is formed by alcohol-induced changes in the serotonin metabolic pathway and is excreted in the urine as a glucuronic acid conjugate. 5-Hydroxytryptophol is elevated in urine excretion and can be used clinically to monitor alcohol intake in scenarios such as alcohol relapse .

HY-W747072

3-Sulfo-taurocholic Acid Disodium Salt 3-Sulfocholyl Taurine; TCA3S	Drug Metabolite	Neurological Disease Metabolic Disease
3-Sulfo-taurocholic Acid Disodium Salt (3-Sulfocholyl Taurine; TCA3S) is a metabolite of the conjugated bile acid taurocholic acid. Plasma levels of 3-Sulfo-taurocholic Acid Disodium Salt are elevated in wild-type and Sortilin 1 (Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated in Sort1 knockout mice at 24 hours post-BDL.

HY-124370

9(Z),11(E)-Conjugated linoleic acid methyl ester 9Z,11E-CLA; Methyl 9(Z),11(E)-octadecadienoate; (9Z,11E)-SFE 19:2	Endogenous Metabolite	Cardiovascular Disease Cancer
9 (Z),11 (E)-Conjugated linoleic acid methyl ester (9Z,11E-CLA; Methyl 9 (Z),11 (E)-octadecadienoate; (9Z,11E)-SFE 19:2) is an isomer of Linoleic acid (HY-N0729), and is a conjugated linoleic acid mainly found in meat and dairy products. Conjugated linoleic acid is a bioactive fatty acid that improves body composition, enhances immune system function, and exhibits anti-cancer and anti-atherosclerotic effects .

HY-126691

DBCO-PEG4-VC-PAB-DMEA-PNU-159682	Drug-Linker Conjugates for ADC	Cancer
DBCO-PEG4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker DBCO-PEG4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682. DBCO-PEG4-VC-PAB-DMEA-PNU-159682 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-41121

Boc-L-Ala-OH 1 Publications Verification Boc-Ala-OH	Amino Acid Derivatives	Cancer
Boc-L-Ala-OH (Boc-Ala-OH) is a single N-protected amino acid ligand and a protected L-alanine derivative. Boc-L-Ala-OH promotes Pd (II)-catalyzed enantioselective C-H alkenylation and kinetic resolution. Boc-L-Ala-OH serves as a coupling reagent for the synthesis of liver-targeted glycogen phosphorylase inhibitors and P6A metabolites, and also acts as a negative control in synthesis studies of betulinic acid amino acid esters. Boc-L-Ala-OH is applicable to research on epidermoid squamous cell carcinoma .

HY-W041895S1

DL-Glutamic acid-d3	Endogenous Metabolite	Others
DL-Glutamic acid-d₃ is the deuterium labeled DL-Glutamic acid. DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability .

HY-N7755

Estradiol 3-glucuronide sodium	Endogenous Metabolite ATP-binding cassette (ABC) transporters OAT	Others
Estradiol 3-glucuronide sodium is an estrogen metabolite, which is a glucuronide conjugate formed by the catalysis of uridine diphosphate glucuronosyltransferase in tissues such as the liver from Estradiol (HY-B0141). Estradiol 3-glucuronide sodium is a potent substrate of Mrp2, with an S₅₀ of 55.7 μM. Estradiol 3-glucuronide sodium achieves hepatobiliary transport in hepatocytes through basolateral uptake via OATP1B1, OATP1B3 and OATP2B1, as well as apical efflux via MRP2 and BCRP .

HY-130082

DM4-SMe	ADC Payload Microtubule/Tubulin	Cancer
DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC₅₀ of 0.026 nM. DM4-SMe is a highly toxic metabolite that can be oxidized and detoxified by human liver microsomes .

HY-W585842

Estradiol 3-glucuronide	Endogenous Metabolite ATP-binding cassette (ABC) transporters OAT	Others
Estradiol 3-glucuronide is an estrogen metabolite, which is a glucuronide conjugate formed from Estradiol (HY-B0141) via catalysis by uridine diphosphate glucuronosyltransferases in tissues such as the liver. Estradiol 3-glucuronide is a potent substrate of Mrp2, with an S₅₀ value of 55.7 μM. Estradiol 3-glucuronide achieves hepatobiliary transport in hepatocytes through basolateral uptake via OATP1B1, OATP1B3 and OATP2B1, as well as apical efflux via MRP2 and BCRP .

HY-148225

Fulvestrant 3-β-D-Glucuronide	Drug Metabolite	Cancer
Fulvestrant 3-β-D-Glucuronide, a *metabolite, is glucuronide and sulfate conjugates* of Fulvestrant (HY-13636), a pure anti-estrogenic steroid. Fulvestrant 3-β-D-Glucuronide can be used for the research of breast cancer .

HY-N1424S

Glycoursodeoxycholic acid-d4 Ursodeoxycholylglycine-d₄	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
Glycoursodeoxycholic acid-d₄ (Ursodeoxycholylglycine-d₄) is the deuterium labeled Glycoursodeoxycholic acid. Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid .

HY-153043

DM-CO-(CH2)5-SMe	Drug Metabolite	Cancer
DM-CO-(CH2)5-SMe is an anticancer agent derived from antibody-drug conjugates (ADC) metabolite with cytotoxicity to H1703, H1975, COLO704 and Colo720E cells .

HY-113095

γ-CEHC 1 Publications Verification	Drug Metabolite Endogenous Metabolite	Others
γ-CEHC is a γ-tocopherol (HY-N7148) metabolite. γ-CEHC is mainly excreted into the urine rather than into the bile. γ-CEHC is present in conjugated form in human urine, mainly as glucuronide .

HY-173243A

Val-Ala-PAB-SN38 TFA	Drug-Linker Conjugates for ADC	Cancer
Val-Ala-PAB-SN38 TFA is a *drug-linker conjugate* for ADC, composed of ADC linker** Val-Ala-PAB (HY-125933) and SN38 (HY-13704), which is the active metabolite of the Topoisomerase I inhibitor Irinotecan (HY-16562) .

HY-N1424R

Glycoursodeoxycholic acid (Standard) GUDCA (Standard); Ursodeoxycholylglycine (Standard)	Reference Standards Endogenous Metabolite	Neurological Disease
Glycoursodeoxycholic acid (Standard) is the analytical standard of Glycoursodeoxycholic acid. This product is intended for research and analytical applications. Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.

HY-W588194

Cotinine N-β-D-Glucuronide	Drug Metabolite	Neurological Disease Metabolic Disease
Cotinine N-β-D-Glucuronide is a glucuronide conjugate of the tobacco metabolite Cotinine (HY-B1178). Cotinine N-β-D-Glucuronide is promising for research of tobacco carcinogen metabolism and cognitive function .

HY-W196803

Dipropyl disulfide Propyl Disulfide; DPDS	Environmental Pollutants Cytochrome P450	Others
Dipropyl disulfide is oxidized to dipropyl thiosulfinate (DPDSO) by rat microsomes. Both flavincontaining monooxygenases (FMO) and cytochrome P450 enzymes (CYPs) are involved in dipropyl disulfide oxidation. Dipropyl disulfide forms two metabolites: propylglutathione sulfide conjugate and propylthiol .

HY-W041895S

DL-Glutamic acid-d5	Isotope-Labeled Compounds Endogenous Metabolite	Others
DL-Glutamic acid-d₅ is the deuterium labeled DL-Glutamic acid. DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability .

HY-116374S

Glycolithocholic acid-d4	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Glycolithocholic acid-d₄ is the deuterium labeled Glycolithocholic acid. Glycolithocholic acid, an endogenous metabolite, is a glycine-conjugated secondary bile acid and can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) .

HY-126995R

Glycohyodeoxycholic acid (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Glycohyodeoxycholic acid (Standard) is the analytical standard of Glycohyodeoxycholic acid. This product is intended for research and analytical applications. Glycohyodeoxycholic acid is a glycine-conjugated bile acid and also a metabolite of Hyodeoxycholic acid (HY-N0169). The serum level of Glycohyodeoxycholic acid is negatively correlated with the severity of non-alcoholic fatty liver disease. Glycohyodeoxycholic acid can be used in research related to non-alcoholic fatty liver disease.

HY-W008646R

7,8-Dihydro-L-biopterin (Standard)	Reference Standards SOD Apoptosis NO Synthase	Others
NADH (disodium salt) (Standard) is the analytical standard of NADH (disodium salt). This product is intended for research and analytical applications. 7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. 7,8-Dihydro-L-biopterin is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. 7,8-Dihydro-L-biopterin promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. 7,8-Dihydro-L-biopterin is sensitive to the inhibitory effect of SOD, and it can be applied to research related to salt-sensitive hypertension, moderate to severe traumatic brain injury, and neurodegenerative diseases .

HY-139909

CL2E-SN38	Drug-Linker Conjugates for ADC	Cancer
CL2E-SN-38, a highly releasable and structurally stable antibody-SN-38-conjugate, is a part of the antibody drug conjugate (ADC). SN-38, the active metabolite of Irinotecan from camptothecins, is an Topoisomerase I inhibitor .

HY-77641S

Cinnamoylglycine-d2	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Cinnamoylglycine-d₂ is the deuterium labeled Cinnamoylglycine. Cinnamoylglycine is a glycine conjugate of cinnamic acid and a urinary metabolite in human. Cinnamoylglycine is used as a potential urinary biomarker indicating intact or disrupted colonization resistance during and after antibiotic treatment .

HY-W751418

N-Nervonoyl taurine (Z)-2-tetracos-15-enamidoethanesulfonic acid	FAAH	Neurological Disease
N-Nervonoyl taurine ((Z)-2-tetracos-15-enamidoethanesulfonic acid) is a fatty acid-taurine conjugate derived from nervonic acid. N-Nervonoyl taurine is a substrate of fatty acid amide hydrolase (FAAH) discovered during metabolite profiling .

HY-116374R

Glycolithocholic acid (Standard) Lithocholylglycine (Standard)	Endogenous Metabolite Reference Standards	Inflammation/Immunology
Glycolithocholic acid (Standard) is the analytical standard of Glycolithocholic acid. This product is intended for research and analytical applications. Glycolithocholic acid (Lithocholylglycine), an endogenous metabolite, is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) .

HY-126689

Mal-Phe-C4-VC-PAB-DMEA-PNU-159682	Drug-Linker Conjugates for ADC	Cancer
Mal-Phe-C4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker Mal-Phe-C4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682 .

HY-129756

Thioacetanilide N-Phenylthioacetamide	Biochemical Assay Reagents	Metabolic Disease
Thioacetanilide (N-Phenylthioacetamide) is a sulfur-containing thioamide derivative of acetanilide. Thioacetanilide displays a solvent‑dependent Z/E isomeric distribution, preferring the E conformation in polar hydrogen‑bonding solvents and the Z conformation in halogenated solvents. Thioacetanilide serves as a substrate for metabolic desulfurization and aromatic hydroxylation. Thioacetanilide is mainly metabolized via desulfurization and 4‑hydroxylation of the aromatic ring in Rattus norvegicus, and the released sulfur integrates into the total body sulfur pool. Thioacetanilide is well absorbed in rats, and more than 90% of the dose is excreted in urine as conjugated metabolites after oral administration .

HY-157338

NHS-Ala-Ala-Asn-active metabolite	ADC Linker Kinesin	Cancer
NHS-Ala-Ala-Asn-active metabolite is a cleavable antibody-drug conjugate (ADC) linker for synthesis of kinesin spindle protein (KSP)inhibitor .

HY-173243

Val-Ala-PAB-SN38	Drug-Linker Conjugates for ADC	Cancer
Val-Ala-PAB-SN38 is a *drug-linker conjugate* for ADC, composed of ADC linker** Val-Ala-PAB (HY-125933) and SN38 (HY-13704), which is the active metabolite of the Topoisomerase I inhibitor Irinotecan (HY-16562) .

HY-N15364

Imidazoleacetic acid riboside	Endogenous Metabolite	Metabolic Disease
Imidazoleacetic acid riboside is a metabolite of histamine, belonging to the riboside conjugates of imidazoleacetic acid. Imidazoleacetic acid riboside is generated by dephosphorylation of imidazoleacetic acid ribonucleotide in rats. Imidazoleacetic acid riboside can be detected in the kidney and brain tissue after administration of labeled histamine or histidine, and exists as a urinary metabolite of histamine in both rats and humans. Imidazoleacetic acid riboside is not only excreted in urine, but also can be used to capture and isolate ribose for studying the metabolic pathways of ribose synthesis from glucose or glucuronolactone via the pentose phosphate pathway or the C-6 oxidation pathway in vivo .

HY-137522S

Zidovudine O-β-D-glucuronide-d3 sodium 3'-Azido-3'-deoxythymidine β-D-glucuronide-d3 sodium	Isotope-Labeled Compounds Drug Metabolite	Others
Zidovudine O-β-D-glucuronide-d₃ sodium (3'-Azido-3'-deoxythymidine β-D-glucuronide-d₃ sodium) is a deuterium labeled Zidovudine O-β-D-glucuronide sodium (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .

HY-179875

N-Cholyl-L-leucine	Endogenous Metabolite	Metabolic Disease
N-Cholyl-L-leucine is a bile acid-amino acid conjugate, mainly produced by intestinal microorganisms. N-Cholyl-L-leucine can be used as a biomarker for premature infants and is also employed in the study of bile acid metabolism .

HY-W777199

Tianeptine metabolite MC5 sodium salt	Drug Metabolite	Others
Tianeptine metabolite MC5 sodium salt is a major active metabolite of tianeptine. Tianeptine and MC5 metabolite are eliminated with bile as glucuronide and glutamine conjugates .

HY-W653947

Glycoursodeoxycholic acid-d5 Ursodeoxycholylglycine-d₅	Isotope-Labeled Compounds Endogenous Metabolite	Neurological Disease
Glycoursodeoxycholic acid-d₅ (Ursodeoxycholylglycine-d₅) is the deuterium labeled Glycoursodeoxycholic acid (HY-N1424). Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.

HY-W196803R

Dipropyl disulfide (Standard) Propyl Disulfide (Standard); DPDS (Standard)	Cytochrome P450 Reference Standards	Others
Dipropyl disulfide is oxidized to dipropyl thiosulfinate (DPDSO) by rat microsomes. Both flavincontaining monooxygenases (FMO) and cytochrome P450 enzymes (CYPs) are involved in dipropyl disulfide oxidation. Dipropyl disulfide forms two metabolites: propylglutathione sulfide conjugate and propylthiol .

HY-77641R

Cinnamoylglycine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Cinnamoylglycine (Standard) is the analytical standard of Cinnamoylglycine. This product is intended for research and analytical applications. Cinnamoylglycine is a glycine conjugate of cinnamic acid and a urinary metabolite in human. Cinnamoylglycine is used as a potential urinary biomarker indicating intact or disrupted colonization resistance during and after antibiotic treatment .

HY-16158R

Cyclacillin (Standard) Wy-4508 (Standard); Aminocyclohexylpenicillin (Standard); Ciclacillin (Standard)	Reference Standards Bacterial Antibiotic	Infection
DL-Glutamic acid (Standard) is the analytical standard of DL-Glutamic acid. This product is intended for research and analytical applications. DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability .

HY-143421

Curcumin monoglucuronide CMG	Drug Metabolite	Cancer
Curcumin monoglucuronide is known as a glucuronic acid conjugate, which is one of the in vivo metabolites of curcumin. Curcumin monoglucuronide is used for research on the metabolism of curcumin and examination of its development as a pharmaceutical. Curcumin monoglucuronide has the potential for the research of cancer disease (extracted from patent WO2022004873A1) .

Cat. No.	Product Name	Target	Research Area

HY-41121

Boc-L-Ala-OH 1 Publications Verification Boc-Ala-OH	Amino Acid Derivatives	Cancer
Boc-L-Ala-OH (Boc-Ala-OH) is a single N-protected amino acid ligand and a protected L-alanine derivative. Boc-L-Ala-OH promotes Pd (II)-catalyzed enantioselective C-H alkenylation and kinetic resolution. Boc-L-Ala-OH serves as a coupling reagent for the synthesis of liver-targeted glycogen phosphorylase inhibitors and P6A metabolites, and also acts as a negative control in synthesis studies of betulinic acid amino acid esters. Boc-L-Ala-OH is applicable to research on epidermoid squamous cell carcinoma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1424

Glycoursodeoxycholic acid 3 Publications Verification GUDCA; Ursodeoxycholylglycine	Structural Classification Endogenous metabolite Steroids Source Classification	Endogenous Metabolite
Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.

HY-116374

Glycolithocholic acid 2 Publications Verification Lithocholylglycine	Human Gut Microbiota Metabolites Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Glycolithocholic acid (Lithocholylglycine), an endogenous metabolite, is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) .

HY-126995

Glycohyodeoxycholic acid	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Glycohyodeoxycholic acid is a glycine-conjugated bile acid and also a metabolite of Hyodeoxycholic acid (HY-N0169). The serum level of Glycohyodeoxycholic acid is negatively correlated with the severity of non-alcoholic fatty liver disease. Glycohyodeoxycholic acid can be used in research related to non-alcoholic fatty liver disease .

HY-125934

Allocholic acid	Microorganisms Animals Classification of Application Fields Disease Research Fields Steroids Source Classification Cancer	Endogenous Metabolite
Allocholic acid is a typically fetal bile acid found in vertebrates and reappears during liver regeneration and carcinogenesis, besides it is also a conjugate acid of allocholate and an isomer of cholic acid. Allocholic acid is a potent and specific stimulant of the adult olfactory system, it has a role as a marine metabolite, a rat metabolite and a human metabolite .

HY-77641

Cinnamoylglycine	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Cinnamoylglycine is a human urinary metabolite and PPG analog. Cinnamoylglycine is a conjugate of cinnamic acid and glycine. Cinnamoylglycine is used as a urine marker. Cinnamoylglycine can be used in adipogenic differentiation studies .

HY-W008646

7,8-Dihydro-L-biopterin 1 Publications Verification	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	SOD Apoptosis NO Synthase
7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. 7,8-Dihydro-L-biopterin is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. 7,8-Dihydro-L-biopterin promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. 7,8-Dihydro-L-biopterin is sensitive to the inhibitory effect of SOD, and it can be applied to research related to salt-sensitive hypertension, moderate to severe traumatic brain injury, and neurodegenerative diseases .

HY-W041019

5-Hydroxytryptophol 1 Publications Verification	Natural Products Monophenols Classification of Application Fields Other Diseases Phenols Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
5-Hydroxytryptophol is a mammalian serotonin metabolite that can be used as a sensitive biomarker for recent alcohol intake. 5-Hydroxytryptophol is formed by alcohol-induced changes in the serotonin metabolic pathway and is excreted in the urine as a glucuronic acid conjugate. 5-Hydroxytryptophol is elevated in urine excretion and can be used clinically to monitor alcohol intake in scenarios such as alcohol relapse .

HY-113095

γ-CEHC 1 Publications Verification	Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Phenols Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite Endogenous Metabolite
γ-CEHC is a γ-tocopherol (HY-N7148) metabolite. γ-CEHC is mainly excreted into the urine rather than into the bile. γ-CEHC is present in conjugated form in human urine, mainly as glucuronide .

HY-N1424R

Glycoursodeoxycholic acid (Standard) GUDCA (Standard); Ursodeoxycholylglycine (Standard)	Structural Classification Microorganisms Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite
Glycoursodeoxycholic acid (Standard) is the analytical standard of Glycoursodeoxycholic acid. This product is intended for research and analytical applications. Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.

HY-126995R

Glycohyodeoxycholic acid (Standard)	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Reference Standards Endogenous Metabolite
Glycohyodeoxycholic acid (Standard) is the analytical standard of Glycohyodeoxycholic acid. This product is intended for research and analytical applications. Glycohyodeoxycholic acid is a glycine-conjugated bile acid and also a metabolite of Hyodeoxycholic acid (HY-N0169). The serum level of Glycohyodeoxycholic acid is negatively correlated with the severity of non-alcoholic fatty liver disease. Glycohyodeoxycholic acid can be used in research related to non-alcoholic fatty liver disease.

HY-W008646R

7,8-Dihydro-L-biopterin (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards SOD Apoptosis NO Synthase
NADH (disodium salt) (Standard) is the analytical standard of NADH (disodium salt). This product is intended for research and analytical applications. 7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. 7,8-Dihydro-L-biopterin is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. 7,8-Dihydro-L-biopterin promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. 7,8-Dihydro-L-biopterin is sensitive to the inhibitory effect of SOD, and it can be applied to research related to salt-sensitive hypertension, moderate to severe traumatic brain injury, and neurodegenerative diseases .

HY-W751418

N-Nervonoyl taurine (Z)-2-tetracos-15-enamidoethanesulfonic acid	Natural Products Endogenous metabolite Source Classification	FAAH
N-Nervonoyl taurine ((Z)-2-tetracos-15-enamidoethanesulfonic acid) is a fatty acid-taurine conjugate derived from nervonic acid. N-Nervonoyl taurine is a substrate of fatty acid amide hydrolase (FAAH) discovered during metabolite profiling .

HY-116374R

Glycolithocholic acid (Standard) Lithocholylglycine (Standard)	Structural Classification Human Gut Microbiota Metabolites Endogenous metabolite Steroids Source Classification	Endogenous Metabolite Reference Standards
Glycolithocholic acid (Standard) is the analytical standard of Glycolithocholic acid. This product is intended for research and analytical applications. Glycolithocholic acid (Lithocholylglycine), an endogenous metabolite, is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) .

HY-N15364

Imidazoleacetic acid riboside	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
Imidazoleacetic acid riboside is a metabolite of histamine, belonging to the riboside conjugates of imidazoleacetic acid. Imidazoleacetic acid riboside is generated by dephosphorylation of imidazoleacetic acid ribonucleotide in rats. Imidazoleacetic acid riboside can be detected in the kidney and brain tissue after administration of labeled histamine or histidine, and exists as a urinary metabolite of histamine in both rats and humans. Imidazoleacetic acid riboside is not only excreted in urine, but also can be used to capture and isolate ribose for studying the metabolic pathways of ribose synthesis from glucose or glucuronolactone via the pentose phosphate pathway or the C-6 oxidation pathway in vivo .

HY-77641R

Cinnamoylglycine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Cinnamoylglycine (Standard) is the analytical standard of Cinnamoylglycine. This product is intended for research and analytical applications. Cinnamoylglycine is a glycine conjugate of cinnamic acid and a urinary metabolite in human. Cinnamoylglycine is used as a potential urinary biomarker indicating intact or disrupted colonization resistance during and after antibiotic treatment .

HY-W041895R

DL-Glutamic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
DL-Glutamic acid (Standard) is the analytical standard of DL-Glutamic acid. This product is intended for research and analytical applications. DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability .

HY-W041019R

5-Hydroxytryptophol (Standard)	Structural Classification Natural Products Monophenols Phenols Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
5-Hydroxytryptophol is a mammalian serotonin metabolite that can be used as a sensitive biomarker for recent alcohol intake. 5-Hydroxytryptophol is formed by alcohol-induced changes in the serotonin metabolic pathway and is excreted in the urine as a glucuronic acid conjugate. 5-Hydroxytryptophol is elevated in urine excretion and can be used clinically to monitor alcohol intake in scenarios such as alcohol relapse .

HY-N15717

(erythro) 1′,2′-Dihydroxyasarone	Natural Products Araceae Acorus gramineus Soland. Plants Source Classification	Drug Metabolite
(erythro) 1′,2′-Dihydroxyasarone is a metabolite of Beta-asarone (HY-N1501) and can also be isolated from the roots of Acorus tatarinowii. (erythro) 1′,2′-Dihydroxyasarone can form glucuronic acid conjugates in vivo and be excreted in urine. (erythro) 1′,2′-Dihydroxyasarone can serve as a marker for the metabolism and toxic risk assessment of Beta-asarone .

HY-N15827

Glyco-ω-muricholanoic acid	Lipid	Endogenous Metabolite
Glyco-ω-muricholanoic acid is an endogenous metabolite and a glycine conjugated bile acid (BA) of ω-Muricholanoic Acid.

HY-N19800

Anhydroicaritin-3,7-di-O-glucuronide	Structural Classification Flavonols Flavonoids Endogenous metabolite Source Classification	Drug Metabolite
Anhydroicaritin-3,7-di-O-glucuronide is a diglucuronide metabolite of icaritin. Anhydroicaritin-3,7-di-O-glucuronide is also a conjugated metabolite derived from prenylated flavonoids of the genus Epimedium in rats. In an in vitro microsomal system, Anhydroicaritin-3,7-di-O-glucuronide is mainly catalyzed by UGT1A1 and UGT1A8. Anhydroicaritin-3,7-di-O-glucuronide is generated via sequential glucuronidation at the 3-OH and 7-OH sites of icaritin, or via further conversion from monoglucuronides of icaritin .

Cat. No.	Product Name	Chemical Structure

HY-W041895S1

DL-Glutamic acid-d3
DL-Glutamic acid-d₃ is the deuterium labeled DL-Glutamic acid. DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability .

HY-N1424S

Glycoursodeoxycholic acid-d4
Glycoursodeoxycholic acid-d₄ (Ursodeoxycholylglycine-d₄) is the deuterium labeled Glycoursodeoxycholic acid. Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid .

HY-W041895S

DL-Glutamic acid-d5
DL-Glutamic acid-d₅ is the deuterium labeled DL-Glutamic acid. DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability .

HY-116374S

Glycolithocholic acid-d4
Glycolithocholic acid-d₄ is the deuterium labeled Glycolithocholic acid. Glycolithocholic acid, an endogenous metabolite, is a glycine-conjugated secondary bile acid and can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) .

HY-77641S

Cinnamoylglycine-d2
Cinnamoylglycine-d₂ is the deuterium labeled Cinnamoylglycine. Cinnamoylglycine is a glycine conjugate of cinnamic acid and a urinary metabolite in human. Cinnamoylglycine is used as a potential urinary biomarker indicating intact or disrupted colonization resistance during and after antibiotic treatment .

HY-137522S

Zidovudine O-β-D-glucuronide-d3 sodium

Zidovudine O-β-D-glucuronide-d₃ sodium (3'-Azido-3'-deoxythymidine β-D-glucuronide-d₃ sodium) is a deuterium labeled Zidovudine O-β-D-glucuronide sodium (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .

HY-W653947

Glycoursodeoxycholic acid-d5
Glycoursodeoxycholic acid-d₅ (Ursodeoxycholylglycine-d₅) is the deuterium labeled Glycoursodeoxycholic acid (HY-N1424). Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.

HY-W750488

Glycolithocholic acid-d5
Glycolithocholic acid-d₅ (Lithocholylglycine-d₅) is the deuterium labeled Glycolithocholic acid (HY-116374). Glycolithocholic acid (Lithocholylglycine), an endogenous metabolite, is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) .

HY-150159S

Cotinine-d3 N-β-D-Glucuronide
Cotinine-d₃ N-β-D-Glucuronide is the deuterium labeled Cotinine N-β-D-Glucuronide (HY-W588194). Cotinine N-β-D-Glucuronide is a glucuronide conjugate of the tobacco metabolite Cotinine (HY-B1178). Cotinine N-β-D-Glucuronide is promising for research of tobacco carcinogen metabolism and cognitive function .

Cat. No.	Product Name		Classification

HY-137522

Zidovudine O-β-D-glucuronide sodium 3'-Azido-3'-deoxythymidine β-D-glucuronide sodium		Azide
Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .

HY-126691

DBCO-PEG4-VC-PAB-DMEA-PNU-159682		DBCO ADC Synthesis
DBCO-PEG4-VC-PAB-DMEA-PNU-159682, a agent-linker conjugate for ADC, consists the ADC linker DBCO-PEG4-VC-PAB and a potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 includes metabolites of nemorubicin (MMDX) from liver microsomes and ADC cytotoxin PNU-159682. DBCO-PEG4-VC-PAB-DMEA-PNU-159682 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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