Val-Ala-PAB-SN38 TFA
Based on 1 Customer Validation
Val-Ala-PAB-SN38 TFA is a drug-linker conjugate for ADC, composed of ADC linker Val-Ala-PAB (HY-125933) and SN38 (HY-13704), which is the active metabolite of the Topoisomerase I inhibitor Irinotecan (HY-16562).
For research use only. We do not sell to patients.
- Purity: 98.22%
- Formula: C40H42F3N5O11
- Molecular Weight:825.78
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 825.78
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Formula C40H42F3N5O11
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Color Off-white to light yellow
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SMILES
O=C1N2C(C(C(C2)=C(C3=C4)CC)=NC3=CC=C4O)=CC5=C1COC([C@@]5(CC)OC(OCC6=CC=C(C=C6)NC([C@H](C)NC([C@@H](N)C(C)C)=O)=O)=O)=O.OC(C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (121.10 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2110 mL | 6.0549 mL | 12.1098 mL | 30.2744 mL |
| 5 mM | 0.2422 mL | 1.2110 mL | 2.4220 mL | 6.0549 mL | |
| 10 mM | 0.1211 mL | 0.6055 mL | 1.2110 mL | 3.0274 mL | |
| 15 mM | 0.0807 mL | 0.4037 mL | 0.8073 mL | 2.0183 mL | |
| 20 mM | 0.0605 mL | 0.3027 mL | 0.6055 mL | 1.5137 mL | |
| 25 mM | 0.0484 mL | 0.2422 mL | 0.4844 mL | 1.2110 mL | |
| 30 mM | 0.0404 mL | 0.2018 mL | 0.4037 mL | 1.0091 mL | |
| 40 mM | 0.0303 mL | 0.1514 mL | 0.3027 mL | 0.7569 mL | |
| 50 mM | 0.0242 mL | 0.1211 mL | 0.2422 mL | 0.6055 mL | |
| 60 mM | 0.0202 mL | 0.1009 mL | 0.2018 mL | 0.5046 mL | |
| 80 mM | 0.0151 mL | 0.0757 mL | 0.1514 mL | 0.3784 mL | |
| 100 mM | 0.0121 mL | 0.0605 mL | 0.1211 mL | 0.3027 mL |
Val-Ala-PAB-SN38 TFA Related Classifications
HY-173243A Related Classifications
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