γ-Linolenic acid NHS ester 

γ-Linolenic acid NHS ester is a lipid metabolite of γ-Linolenic acid (GLA) (HY-N7140), which can serve as a synthetic intermediate or probe labeling reagent for the preparation of GLA conjugates. In practical applications, γ-Linolenic acid NHS ester can be conjugated with taxanes and polysaccharides to form dual-type conjugates for drug delivery purposes^[1].

Taxanes are natural and semi-synthetic derivatives with a taxane diterpene skeleton. They exhibit significant anticancer activity through the mechanism of inhibiting cell mitosis and are widely used in the research of various solid tumors such as breast cancer and ovarian cancer. However, taxanes have extremely poor water solubility, so clinical formulations rely on cosolvents containing PEG moieties, such as Cremophor EL and Tween-80. These cosolvents easily induce hypersensitivity reactions, nephrotoxicity, neurotoxicity, neutropenia, and other adverse effects, which can even cause death in severe cases^[1].
As an ester compound, γ-Linolenic acid NHS ester is an important component of cells, tends to accumulate in tumor tissues, and can improve the in vivo absorption and distribution of drugs, enhance safety, and reduce toxic and side effects. Conjugating taxanes with γ-Linolenic acid NHS ester has the potential to solve problems of taxanes such as poor solubility, low bioavailability, severe toxic and side effects, and lack of tumor targeting^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

375.50

C₂₂H₃₃NO₄

216447-57-3

O=C(CC1)N(OC(CCCC/C=C\C/C=C\C/C=C\CCCCC)=O)C1=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Cheng Haijun, et al. Paclitaxel-lipid-polysaccharide dual-type conjugate, preparation method therefor and use thereof. WO2019242691A1.