γ-Linolenic acid NHS ester

Taxanes are natural and semi-synthetic derivatives with a taxane diterpene skeleton. They exhibit significant anticancer activity through the mechanism of inhibiting cell mitosis and are widely used in the research of various solid tumors such as breast cancer and ovarian cancer. However, taxanes have extremely poor water solubility, so clinical formulations rely on cosolvents containing PEG moieties, such as Cremophor EL and Tween-80. These cosolvents easily induce hypersensitivity reactions, nephrotoxicity, neurotoxicity, neutropenia, and other adverse effects, which can even cause death in severe cases^[1].
As an ester compound, γ-Linolenic acid NHS ester is an important component of cells, tends to accumulate in tumor tissues, and can improve the in vivo absorption and distribution of drugs, enhance safety, and reduce toxic and side effects. Conjugating taxanes with γ-Linolenic acid NHS ester has the potential to solve problems of taxanes such as poor solubility, low bioavailability, severe toxic and side effects, and lack of tumor targeting^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.