Anhydroicaritin-3,7-di-O-glucuronide 

Anhydroicaritin-3,7-di-O-glucuronide is a diglucuronide metabolite of icaritin. Anhydroicaritin-3,7-di-O-glucuronide is also a conjugated metabolite derived from prenylated flavonoids of the genus *Epimedium* in rats. In an in vitro microsomal system, Anhydroicaritin-3,7-di-O-glucuronide is mainly catalyzed by UGT1A1 and UGT1A8. Anhydroicaritin-3,7-di-O-glucuronide is generated via sequential glucuronidation at the 3-OH and 7-OH sites of icaritin, or via further conversion from monoglucuronides of icaritin^[1][2].

Anhydroicaritin-3,7-di-O-glucuronide forms as an in vivo metabolite in rats after oral administration of epimedin C (HY-N0260), Icariin (HY-N0014), Baohuoside I (HY-N0011), or Epimedium extracts, and persists in plasma for up to 12 h post-dosing in epimedin C-treated rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

720.63

C₃₃H₃₆O₁₈

1231899-06-1

C/C(C)=C\CC1=C2C(C(C(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O)=C(C4=CC=C(C=C4)OC)O2)=O)=C(C=C1O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)C(O)=O)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Rong Y, et al. Application of ultra high-performance liquid chromatography tandem mass spectrometry to investigate the regioselective glucuronidation of icaritin in vitro[J]. Journal of Pharmaceutical and Biomedical Analysis, 2018, 154: 444-453.

  [2]. Zhao H, et al. Liquid chromatography-tandem mass spectrometry analysis of metabolites in rats after administration of prenylflavonoids from Epimediums. J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878(15-16):1113-1124.