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Cat. No.: HY-N19800

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Anhydroicaritin-3,7-di-O-glucuronide

Anhydroicaritin-3,7-di-O-glucuronide is a diglucuronide metabolite of icaritin. Anhydroicaritin-3,7-di-O-glucuronide is also a conjugated metabolite derived from prenylated flavonoids of the genus *Epimedium* in rats. In an in vitro microsomal system, Anhydroicaritin-3,7-di-O-glucuronide is mainly catalyzed by UGT1A1 and UGT1A8. Anhydroicaritin-3,7-di-O-glucuronide is generated via sequential glucuronidation at the 3-OH and 7-OH sites of icaritin, or via further conversion from monoglucuronides of icaritin.

For research use only. We do not sell to patients.

CAS No.: 1231899-06-1
Formula: C₃₃H₃₆O₁₈
Molecular Weight:720.63

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Please store the product under the recommended conditions in the Certificate of Analysis.

Anhydroicaritin-3,7-di-O-glucuronide Chemical Structure

CAS No.: 1231899-06-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vivo
Chemical Information
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Biological Activity

Description

In Vivo

Anhydroicaritin-3,7-di-O-glucuronide forms as an in vivo metabolite in rats after oral administration of epimedin C (HY-N0260), Icariin (HY-N0014), Baohuoside I (HY-N0011), or Epimedium extracts, and persists in plasma for up to 12 h post-dosing in epimedin C-treated rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1231899-06-1
Molecular Weight 720.63
Formula C₃₃H₃₆O₁₈
SMILES

C/C(C)=C\CC1=C2C(C(C(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O)=C(C4=CC=C(C=C4)OC)O2)=O)=C(C=C1O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)C(O)=O)O
Structure Classification
- Flavonoids
- Flavonols
Initial Source
- Endogenous metabolite
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Rong Y, et al. Application of ultra high-performance liquid chromatography tandem mass spectrometry to investigate the regioselective glucuronidation of icaritin in vitro[J]. Journal of Pharmaceutical and Biomedical Analysis, 2018, 154: 444-453.

[2]. Zhao H, et al. Liquid chromatography-tandem mass spectrometry analysis of metabolites in rats after administration of prenylflavonoids from Epimediums. J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878(15-16):1113-1124. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Anhydroicaritin-3,7-di-O-glucuronide

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Anhydroicaritin-3,7-di-O-glucuronide

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Anhydroicaritin-3,7-di-O-glucuronide Related Classifications

HY-N19800 Related Classifications

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