9(Z),11(E)-Conjugated linoleic acid methyl ester
Based on 1 Customer Validation
9 (Z),11 (E)-Conjugated linoleic acid methyl ester (9Z,11E-CLA; Methyl 9 (Z),11 (E)-octadecadienoate; (9Z,11E)-SFE 19:2) is an isomer of Linoleic acid (HY-N0729), and is a conjugated linoleic acid mainly found in meat and dairy products. Conjugated linoleic acid is a bioactive fatty acid that improves body composition, enhances immune system function, and exhibits anti-cancer and anti-atherosclerotic effects.
For research use only. We do not sell to patients.
- Purity: 99.2%
- CAS No.: 13058-52-1
- Formula: C19H34O2
- Molecular Weight:294.47
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-N0729
Linoleic acid
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HY-N0728
α-Linolenic acid
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HY-121952
(9E,11E)-9,11-Octadecadienoic acid methyl ester
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HY-N0729D
Linoleic acid,suitable for cell culture
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HY-N0729R
Linoleic acid (Standard)
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HY-N0728R
α-Linolenic acid (Standard)
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HY-141553
Methyl alpha-eleostearate
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HY-W347368
9Z,11E,13Z-Octadecatrienoicacid, methylester
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HY-W923357
9(Z),11(Z)-Conjugated linoleic acid methyl ester
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HY-W071746
Linolelaidic acid
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HY-W005627
Linoleyl alcohol
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HY-116768
10(E),12(Z)-Conjugated linoleic acid methyl ester
All Endogenous Metabolite Isoforms
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Biological Activity
9 (Z),11 (E)-Conjugated linoleic acid methyl ester activates de novo synthesis of phosphatidylcholine (LPC) and phosphatidylethanolamine via the Kennedy pathway in primary monocyte-derived macrophages, shifts and integrates their species profile toward 18:2/18:2, and simultaneously induces desaturation and elongation reactions to generate conjugated fatty acids such as 18:3 and 20:4. In addition, 9 (Z),11 (E)-Conjugated linoleic acid methyl ester preferentially binds to triglycerides and cholesterol esters, and undergoes further elongation metabolism inside cells to form conjugated fatty acid products including 20:2 and 22:2[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 13058-52-1
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Appearance Liquid (Density: 0.884±0.06 g/cm3)
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Molecular Weight 294.47
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Formula C19H34O2
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Color Colorless to light yellow
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SMILES
CCCCCC/C=C/C=C\CCCCCCCC(OC)=O
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Synonyms
9Z,11E-CLA; Methyl 9(Z),11(E)-octadecadienoate; (9Z,11E)-SFE 19:2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (339.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Ecker J, et al. Differential effects of conjugated linoleic acid isomers on macrophage glycerophospholipid metabolism. J Lipid Res. 2010;51(9):2686-2694. [Content Brief]
[2]. Ringseis R, et al. Formation of conjugated linoleic acid metabolites in human vascular endothelial cells. Biochim Biophys Acta. 2006;1761(3):377-383. [Content Brief]
[3]. Whigham LD, et al., Conjugated linoleic acid: implications for human health. Pharmacol Res. 2000 Dec;42(6):503-10. [Content Brief]
[4]. Saba A, et al., Identification of 9(E),11(E)-18:2 fatty acid methyl ester at trace level in thermal stressed olive oils by GC coupled to acetonitrile CI-MS and CI-MS/MS, a possible marker for adulteration by addition of deodorized olive oil. J Agric Food Chem. 2005 Jun 15;53(12):4867-72. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3959 mL | 16.9797 mL | 33.9593 mL | 84.8983 mL |
| 5 mM | 0.6792 mL | 3.3959 mL | 6.7919 mL | 16.9797 mL | |
| 10 mM | 0.3396 mL | 1.6980 mL | 3.3959 mL | 8.4898 mL | |
| 15 mM | 0.2264 mL | 1.1320 mL | 2.2640 mL | 5.6599 mL | |
| 20 mM | 0.1698 mL | 0.8490 mL | 1.6980 mL | 4.2449 mL | |
| 25 mM | 0.1358 mL | 0.6792 mL | 1.3584 mL | 3.3959 mL | |
| 30 mM | 0.1132 mL | 0.5660 mL | 1.1320 mL | 2.8299 mL | |
| 40 mM | 0.0849 mL | 0.4245 mL | 0.8490 mL | 2.1225 mL | |
| 50 mM | 0.0679 mL | 0.3396 mL | 0.6792 mL | 1.6980 mL | |
| 60 mM | 0.0566 mL | 0.2830 mL | 0.5660 mL | 1.4150 mL | |
| 80 mM | 0.0424 mL | 0.2122 mL | 0.4245 mL | 1.0612 mL | |
| 100 mM | 0.0340 mL | 0.1698 mL | 0.3396 mL | 0.8490 mL |
9(Z),11(E)-Conjugated linoleic acid methyl ester Related Classifications
HY-124370 Related Classifications
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- 9(Z),11(E)-Conjugated linoleic acid methyl ester
- 13058-52-1
- 9Z,11E-CLA
- Methyl 9(Z),11(E)-octadecadienoate
- (9Z,11E)-SFE 19:2
- Endogenous Metabolite
- phosphatidylethanolamine
- metabolite precursor
- triglycerides
- glycerophospholipids
- conjugated fatty acids
- primary monocyte-derived macrophages
- phosphatidylcholine
- Kennedy pathway
- conjugated linoleic acid isomer
- neutral lipid incorporator
- Inhibitor
- inhibitor
- inhibit