Imidazoleacetic acid riboside 

Imidazoleacetic acid riboside is a metabolite of histamine, belonging to the riboside conjugates of imidazoleacetic acid. Imidazoleacetic acid riboside is generated by dephosphorylation of imidazoleacetic acid ribonucleotide in rats. Imidazoleacetic acid riboside can be detected in the kidney and brain tissue after administration of labeled histamine or histidine, and exists as a urinary metabolite of histamine in both rats and humans. Imidazoleacetic acid riboside is not only excreted in urine, but also can be used to capture and isolate ribose for studying the metabolic pathways of ribose synthesis from glucose or glucuronolactone via the pentose phosphate pathway or the C-6 oxidation pathway in vivo^[1][2][3].

Imidazoleacetic acid riboside is endogenously formed in rat brain from intracerebroventricularly administered [³H]histamine, with levels increasing 3- to 10-fold when histamine methylation is blocked by Metoprine (HY-129441), while formation is negligible after intracisternal [³H]histamine administration^[1].
Imidazoleacetic acid riboside is identified as an in vivo metabolite of histamine and histidine in rat kidney and brain^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

258.23

C₁₀H₁₄N₂O₆

29605-99-0

O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C=C(CC(O)=O)N=C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Thomas B, et al. Imidazoleacetic acid, a gamma-aminobutyric acid receptor agonist, can be formed in rat brain by oxidation of histamine. J Neurochem. 1995;65(2):818-826.  [Content Brief]

  [2]. Robinson J D, et al. Presence of imidazoleacetic acid riboside and ribotide in rat tissues[J]. Nature, 1964, 203(4950): 1178-1179.

  [3]. Hiatt H H. Studies of ribose metabolism. VI. Pathways of ribose synthesis in man[J]. The Journal of Clinical Investigation, 1958, 37(10): 1461-1464.