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Cat. No.: HY-N15364

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Imidazoleacetic acid riboside

Imidazoleacetic acid riboside is a metabolite of histamine, belonging to the riboside conjugates of imidazoleacetic acid. Imidazoleacetic acid riboside is generated by dephosphorylation of imidazoleacetic acid ribonucleotide in rats. Imidazoleacetic acid riboside can be detected in the kidney and brain tissue after administration of labeled histamine or histidine, and exists as a urinary metabolite of histamine in both rats and humans. Imidazoleacetic acid riboside is not only excreted in urine, but also can be used to capture and isolate ribose for studying the metabolic pathways of ribose synthesis from glucose or glucuronolactone via the pentose phosphate pathway or the C-6 oxidation pathway in vivo.

For research use only. We do not sell to patients.

CAS No.: 29605-99-0
Formula: C₁₀H₁₄N₂O₆
Molecular Weight:258.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Imidazoleacetic acid riboside Chemical Structure

CAS No.: 29605-99-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vivo

Imidazoleacetic acid riboside is endogenously formed in rat brain from intracerebroventricularly administered [³H]histamine, with levels increasing 3- to 10-fold when histamine methylation is blocked by Metoprine (HY-129441), while formation is negligible after intracisternal [³H]histamine administration^[1].
Imidazoleacetic acid riboside is identified as an in vivo metabolite of histamine and histidine in rat kidney and brain^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 29605-99-0
Molecular Weight 258.23
Formula C₁₀H₁₄N₂O₆
SMILES

O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C=C(CC(O)=O)N=C2
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Thomas B, et al. Imidazoleacetic acid, a gamma-aminobutyric acid receptor agonist, can be formed in rat brain by oxidation of histamine. J Neurochem. 1995;65(2):818-826. [Content Brief]

[2]. Robinson J D, et al. Presence of imidazoleacetic acid riboside and ribotide in rat tissues[J]. Nature, 1964, 203(4950): 1178-1179.

[3]. Hiatt H H. Studies of ribose metabolism. VI. Pathways of ribose synthesis in man[J]. The Journal of Clinical Investigation, 1958, 37(10): 1461-1464.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References

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Imidazoleacetic acid riboside

All Endogenous Metabolite Isoforms