29605-99-0
Chemical Structure
Imidazoleacetic acid riboside
- CAS No.: 29605-99-0
- Formula:C10H14N2O6
- Molecular Weight:258.23
InChIKey: AHPWEWASPTZMEK-PEBGCTIMSA-N
SMILES: O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C=C(CC(O)=O)N=C2
Biological Activity: Imidazoleacetic acid riboside is a metabolite of histamine, belonging to the riboside conjugates of imidazoleacetic acid. Imidazoleacetic acid riboside is generated by dephosphorylation of imidazoleacetic acid ribonucleotide in rats. Imidazoleacetic acid riboside can be detected in the kidney and brain tissue after administration of labeled histamine or histidine, and exists as a urinary metabolite of histamine in both rats and humans. Imidazoleacetic acid riboside is not only excreted in urine, but also can be used to capture and isolate ribose for studying the metabolic pathways of ribose synthesis from glucose or glucuronolactone via the pentose phosphate pathway or the C-6 oxidation pathway in vivo[1][2][3].
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Imidazoleacetic acid riboside | Imidazoleacetic acid riboside is a metabolite of histamine, belonging to the riboside conjugates of imidazoleacetic acid. Imidazoleacetic acid riboside is generated by dephosphorylation of imidazoleacetic acid ribonucleotide in rats. Imidazoleacetic acid riboside can be detected in the kidney and brain tissue after administration of labeled histamine or histidine, and exists as a urinary metabolite of histamine in both rats and humans. Imidazoleacetic acid riboside is not only excreted in urine, but also can be used to capture and isolate ribose for studying the metabolic pathways of ribose synthesis from glucose or glucuronolactone via the pentose phosphate pathway or the C-6 oxidation pathway in vivo. | |||||||||||||||||||||
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- [1]. Thomas B, et al. Imidazoleacetic acid, a gamma-aminobutyric acid receptor agonist, can be formed in rat brain by oxidation of histamine. J Neurochem. 1995;65(2):818-826. [Content Brief]
- [2]. Robinson J D, et al. Presence of imidazoleacetic acid riboside and ribotide in rat tissues[J]. Nature, 1964, 203(4950): 1178-1179.
- [3]. Hiatt H H. Studies of ribose metabolism. VI. Pathways of ribose synthesis in man[J]. The Journal of Clinical Investigation, 1958, 37(10): 1461-1464.
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