MM-433593
MM-433593 is a potent and selective inhibitor of fatty acid amide hydrolase-1 (FAAH-1) that is orally administered to inhibit pain, inflammation, and related disorders. Pharmacokinetic studies of MM-433593 in macaques revealed a biphasic elimination profile with a rapid distribution phase and a slower elimination phase, with a systemic clearance of 8-11 mL/min/kg. MM-433593 exhibits moderate oral bioavailability (14-21%) and its metabolism primarily involves oxidation of the methyl group on the indole ring, resulting in a variety of sulfate, glucuronide, or glutathione-conjugated metabolites.
For research use only. We do not sell to patients.
- CAS No.: 1006604-91-6
- Formula: C25H22ClN3O3
- Molecular Weight:447.91
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 1006604-91-6
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Molecular Weight 447.91
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Formula C25H22ClN3O3
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SMILES
COC1=CC(NC(C(C2=C(C)N(CC3=CC=C(Cl)C=C3)C4=CC=C(C)C=C24)=O)=O)=CC=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MM-433593 Related Classifications
HY-115004 Related Classifications
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