2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. N-Cholyl-L-leucine

N-Cholyl-L-leucine is a bile acid-amino acid conjugate, mainly produced by intestinal microorganisms. N-Cholyl-L-leucine can be used as a biomarker for premature infants and is also employed in the study of bile acid metabolism.

For research use only. We do not sell to patients.

N-Cholyl-L-leucine

N-Cholyl-L-leucine Chemical Structure

CAS No. : 22154-46-7

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N-Cholyl-L-leucine Related Antibodies

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Description

N-Cholyl-L-leucine is a bile acid-amino acid conjugate, mainly produced by intestinal microorganisms. N-Cholyl-L-leucine can be used as a biomarker for premature infants and is also employed in the study of bile acid metabolism[1].

Molecular Weight

521.73

Formula

C30H51NO6
CAS No.
Appearance

Solid

SMILES

O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCC(N[C@H](C(O)=O)CC(C)C)=O)([C@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C1)C)O)C
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 75 mg/mL (143.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9167 mL 9.5835 mL 19.1670 mL
5 mM 0.3833 mL 1.9167 mL 3.8334 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.51%

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9167 mL 9.5835 mL 19.1670 mL 47.9175 mL
5 mM 0.3833 mL 1.9167 mL 3.8334 mL 9.5835 mL
10 mM 0.1917 mL 0.9584 mL 1.9167 mL 4.7918 mL
15 mM 0.1278 mL 0.6389 mL 1.2778 mL 3.1945 mL
20 mM 0.0958 mL 0.4792 mL 0.9584 mL 2.3959 mL
25 mM 0.0767 mL 0.3833 mL 0.7667 mL 1.9167 mL
30 mM 0.0639 mL 0.3195 mL 0.6389 mL 1.5973 mL
40 mM 0.0479 mL 0.2396 mL 0.4792 mL 1.1979 mL
50 mM 0.0383 mL 0.1917 mL 0.3833 mL 0.9584 mL
60 mM 0.0319 mL 0.1597 mL 0.3195 mL 0.7986 mL
80 mM 0.0240 mL 0.1198 mL 0.2396 mL 0.5990 mL
100 mM 0.0192 mL 0.0958 mL 0.1917 mL 0.4792 mL
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N-Cholyl-L-leucine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Cholyl-L-leucine22154-46-7Endogenous Metabolitereverse metabolomicsbile acid conjugatesN-cholyl-L-leucineinflammatory bowel diseasemicrobiome-host interactionsmass spectrometrymicrobial metabolitesCrohn's diseasePXR agonistimmunomodulationInhibitorinhibitorinhibit

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