Search Result

Results for "

fat mass

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Fat Mass and Obesity-associated Protein (FTO) (17) 5-HT Receptor (1) ACSL Family (1) Adrenergic Receptor (8) Amylin Receptor (5) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (4) Antibiotic (1) Apoptosis (3) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (3) Caspase (1) CGRP Receptor (1) Cytochrome P450 (1) Endogenous Metabolite (9) Gap Junction Protein (5) GLP Receptor (2) Glycosyltransferase (1) HSP (1) Isotope-Labeled Compounds (9) NF-κB (1) Parasite (1) PARP (1) Potassium Channel (3) PPAR (1) PROTACs (1) Reference Standards (4) TGF-beta/Smad (1) TGF-β Receptor (1) Thyroid Hormone Receptor (1) Trace Amine-associated Receptor (TAAR) (5) YTHDF (1)
By Research Areas:	Cancer (16) Endocrinology (6) Infection (1) Inflammation/Immunology (6) Metabolic Disease (30) Neurological Disease (6)

By Targets:

Fat Mass and Obesity-associated Protein (FTO) (17)

5-HT Receptor (1)

ACSL Family (1)

Adrenergic Receptor (8)

Amylin Receptor (5)

Anaplastic lymphoma kinase (ALK) (1)

Androgen Receptor (4)

Antibiotic (1)

Apoptosis (3)

Autophagy (1)

Bacterial (1)

Biochemical Assay Reagents (3)

Caspase (1)

CGRP Receptor (1)

Cytochrome P450 (1)

Endogenous Metabolite (9)

Gap Junction Protein (5)

GLP Receptor (2)

Glycosyltransferase (1)

HSP (1)

Isotope-Labeled Compounds (9)

NF-κB (1)

Parasite (1)

PARP (1)

Potassium Channel (3)

PPAR (1)

PROTACs (1)

Reference Standards (4)

TGF-beta/Smad (1)

TGF-β Receptor (1)

Thyroid Hormone Receptor (1)

Trace Amine-associated Receptor (TAAR) (5)

YTHDF (1)

By Research Areas:

Cancer (16)

Endocrinology (6)

Infection (1)

Inflammation/Immunology (6)

Metabolic Disease (30)

Neurological Disease (6)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Fat Mass and Obesity-associated Protein (FTO)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P10745

Petrelintide ZP8396	Amylin Receptor	Metabolic Disease
Petrelintide (ZP8396) is a dual amylin and calcitonin receptor agonist (DACRA) Petrelintide elicits a selective reduction in high-fat diet intake in diet-induced obese (DIO) rats, which is accompanied by a loss of fat mass and preservation of lean mass during weight reduction. Petrelintide can be utilized in diabetes research .

HY-P10745A

Petrelintide acetate ZP8396 acetate	Amylin Receptor	Metabolic Disease
Perelintide (ZP8396) acetate is a dual amylin and calcitonin receptor agonist (DACRA). Perelintide acetate elicits a selective reduction in high-fat diet intake in diet-induced obese (DIO) rats, which is accompanied by a loss of fat mass and preservation of lean mass during weight reduction. Perelintide acetate can be utilized in diabetes research .

HY-117275

Meclofenamic acid Maximum Cited Publications 8 Publications Verification Meclofenamate	Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite	Neurological Disease Metabolic Disease Inflammation/Immunology
Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC₅₀ values of 56.0 and 155.9 μM, respectively .

HY-N6769

Radicicol 4 Publications Verification Monorden	HSP Bacterial Antibiotic Parasite	Infection
Radicicol is an inhibitor of Hsp90 with an IC₅₀ value < 1 μM, and leads to proteasomal degradation . Radicicol exhibits inhibition on PDK with IC₅₀s of 230 μM (PDK1) and 400 μM (PDK3). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB . Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC₅₀ value of 16.04 μM .

HY-P11245A

NN1213 acetate	Amylin Receptor	Metabolic Disease
NN1213 acetate, a long-acting human amylin peptide analog, is a selective Amylin receptor agonist with EC₅₀ values of 0.177 and 0.262 nM for hAMY3R and rAMY3R, respectively. NN1213 acetate significantly reduces food intake and fat mass. NN1213 acetate can reduce body weightin diet-induced obese rats. NN1213 acetate can be used for the research of obesity .

HY-N1993

5-Methyl-7-methoxyisoflavone 3 Publications Verification	Cytochrome P450 NF-κB	Metabolic Disease Cancer
5-Methyl-7-methoxyisoflavone is an orally active anti-oxidant with remyelinating activity. 5-Methyl-7-methoxyisoflavone inhibits the enzyme aromatase, interfering with the normal metabolic pathways of testosterone. 5-Methyl-7-methoxyisoflavone is a non-steroidal anabolic isoflavone, used as a anabolic agent. 5-Methyl-7-methoxyisoflavone shows better potency increasing muscle mass and endurance than Ipriflavone (HY-N0094). 5-Methyl-7-methoxyisoflavone can be used for fat loss besides the maintenance of low cholesterol level and strengthen bones. 5-Methyl-7-methoxyisoflavone is the inhibitor for NF-κB .

HY-P991504

LAE-102	Anaplastic lymphoma kinase (ALK) TGF-β Receptor TGF-beta/Smad	Metabolic Disease Cancer
LAE-102 is the selective anti-ActRIIA (activin receptor type IIA or ACVR2) monoclonal antibody. LAE-102 increases muscle mass and reduces fat mass. LAE102 can increase serum activin A levels in vivo. LAE-102 is promising for research of obesity .

HY-N2840

Allitol 1 Publications Verification Allodulcitol	Others	Metabolic Disease
Allitol (Allodulcitol) is an orally active rare sugar alcohol found in Itea virginica L, Tylopilus plumbeoviolaceus. Allitol has anti-obesity and hypoglycaemic activities. Allitol reduces carcass and total body fat mass, increases cecal weight, surface area, and short-chain fatty acid production, and upregulates cecal microbial enzymes linked to butyrate metabolism. Allitol can be used for the researches of obesity and diabetes .

HY-P11245

NN1213	Amylin Receptor	Metabolic Disease
NN1213, a long-acting human amylin peptide analog, is a selective Amylin receptor agonist with EC₅₀ values of 0.177 and 0.262 nM for hAMY3R and rAMY3R, respectively. NN1213 significantly reduces food intake and fat mass. NN1213 can reduce body weightin diet-induced obese rats. NN1213 can be used for the research of obesity .

HY-174979

Dac590	Fat Mass and Obesity-associated Protein (FTO) Apoptosis	Inflammation/Immunology Cancer
Dac590 is an orally active and selective obesity-associated protein (FTO) inhibitor with an IC₅₀ of 6.06 nM. Dac590 shows highly selective over ALKBH5 and ALKBH3. Dac590 suppresses oncogenic FTO signaling, induces myeloid differentiation, G1-phase cell cycle arrest, and apoptosis in acute myeloid leukemia (AML) cells. Dac590 inhibits xenograft tumor growth and prolongs survival in acute myeloid leukemia mouse models with no observed toxicity. Dac590 can be used for the research of AML .

HY-B1421

Ractopamine hydrochloride LY031537	Adrenergic Receptor Trace Amine-associated Receptor (TAAR)	Metabolic Disease
Ractopamine hydrochloride (LY031537) is a potent and orally active β-adrenergic receptor (βAR) agonist with K_d value of ~25 nM for pig β1AR and β2AR. Ractopamine hydrochloride also is a mTAAR1 agonist with an EC₅₀ of 16 μM. Ractopamine hydrochloride promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-149334

ZLD115	Fat Mass and Obesity-associated Protein (FTO)	Metabolic Disease
ZLD115 (compound 44) is a FB23-derivated inhibitor of Fat Mass and Obesity-associated Protein (FTO). ZLD115 is an antileukemic agent, exhibiting antiproliferative activity against leukemic cell lines .

HY-17462

Adrenosterone (+)-Adrenosterone	Androgen Receptor Endogenous Metabolite	Endocrinology Cancer
Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .

HY-138843A

FTO-IN-1 TFA 1 Publications Verification	Fat Mass and Obesity-associated Protein (FTO)	Metabolic Disease Cancer
FTO-IN-1 TFA is a fat mass and obesity-associated enzyme (FTO) inhibitor extracted from patent WO2018157843A1, compound 32, with an IC₅₀ of <1 μM. FTO-IN-1 TFA can be used for the research of cancer .

HY-151106

FTO-IN-8	Fat Mass and Obesity-associated Protein (FTO)	Cancer
FTO-IN-8 (FTO-43) is a N6-methyladenosine demethylase (FTO) (fat mass- and obesity-associated protein) inhibitor with the IC₅₀ value of 5.5 μM. FTO-IN-8 has anti-cancer cell proliferative activity .

HY-138843

FTO-IN-1	Fat Mass and Obesity-associated Protein (FTO)	Metabolic Disease Cancer
FTO-IN-1 is a fat mass and obesity-associated enzyme (FTO) inhibitor extracted from patent WO2018157843A1, compound 32, with an IC₅₀ of <1 μM. FTO-IN-1 can be used for the research of cancer .

HY-147011

FTO-IN-7	Fat Mass and Obesity-associated Protein (FTO)	Cancer
FTO-IN-7 (compound 17) is an inhibitor of *FTO (fat* mass and obesity-associated protein) with an IC₅₀** of <1 μM. FTO-IN-7 can be used for the study of small-cell lung cancers and human bone marrow striated muscle cancer .

HY-175885

PROTAC FTO degrader 1	PROTACs Fat Mass and Obesity-associated Protein (FTO) Apoptosis Caspase PARP YTHDF	Cancer
PROTAC FTO degrader 1 is a Fat Mass and Obesity-associated Protein (FTO) PROTAC degrader. PROTAC FTO degrader 1 selectively degrades FTO depending on VHL E3 ligase and ubiquitin-proteasome system. PROTAC FTO degrader 1 can increase m₆A modifications on mRNAs associated with ribosome biogenesis and promote their YTHDF2-mediated decay. PROTAC FTO degrader 1 can inhibit cancer cells proliferation and induce apoptosis. PROTAC FTO degrader 1 can be used for the research of cancer, such as acute myeloid leukemia (AML) . (Structure Note: Pink: FTO ligand (HY-175886); Blue: VHL ligand (HY-112078); Black: linker (HY-W002042); VHL ligand-Linker: (HY-139218))

HY-134577

Clorprenaline	Adrenergic Receptor	Endocrinology
Clorprenaline is a potent agonist of β2-adrenergic. Clorprenaline promotes animal muscular mass growth and decreases fat accumulation. Clorprenaline is a potential new lean meat-boosting feed additive .

HY-145238

FTO-IN-6	Fat Mass and Obesity-associated Protein (FTO)	Others
FTO-IN-6 is a selective fat mass and obesity associated protein (FTO) inhibitor.

HY-139821

FTO-IN-5	Fat Mass and Obesity-associated Protein (FTO)	Neurological Disease Cancer
FTO-IN-5 is a potent and selective inhibitor of fat mass obesity-associated protein (FTO).

HY-W721874

Adrenosterone-d10 (+)-Adrenosterone-d₁₀	Isotope-Labeled Compounds Endogenous Metabolite Androgen Receptor	Cancer
Adrenosterone-d₁₀ ((+)-Adrenosterone-d₁₀) is the deuterium labeled Adrenosterone (HY-17462). Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .

HY-W588293

3-Methylthymidine	Fat Mass and Obesity-associated Protein (FTO)	Others
3-Methylthymidine can be used to detect fat mass and obesity-associated protein (FTO) activity .

HY-120872

AJS1669 free acid	Glycosyltransferase	Metabolic Disease
AJS1669 free acid is a potent and orally available glycogen synthase (GS) activator. AJS1669 improves glucose metabolism and reduces body fat mass in mice[1].

HY-N10340

Clausine E Clauszoline I	Others	Cancer
Clausine E, is a alkaloid which can be isolated from Clausena excavata, is a inhibitor of fat mass and obesity-associated protein (FTO) demethylase. Clausine E shows inhibitory activities against proliferation of synoviocytes and cancer cells.

HY-W026109

FTO-IN-12	Fat Mass and Obesity-associated Protein (FTO)	Neurological Disease
FTO-IN-12 (Compound 2) is an inhibitor of fat mass and obesity-related protein (FTO). K_d and IC₅₀ values are 185 nM and 1.46 μM, respectively. FTO-IN-12 can be used in the study of neurodegenerative diseases .

HY-117275A

Meclofenamic acid sodium hydrate Meclofenamate sodium hydrate	Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite	Neurological Disease Metabolic Disease Inflammation/Immunology
Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selective gap-junction blocker. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC₅₀ values of 56.0 and 155.9 μM, respectively .

HY-W127851

CLA Cypridina luciferin analog	Biochemical Assay Reagents	Others Cancer
CLA, or conjugated linoleic acid, is a polyunsaturated fatty acid that occurs naturally in a variety of animal products, such as meat and dairy. It has several potential benefits for human health, including the ability to reduce body fat mass, improve insulin sensitivity, and reduce inflammation. CLA has been extensively studied for its effects on weight loss and muscle growth, as well as its potential role in preventing chronic diseases such as heart disease and cancer. Additionally, it can be taken as a dietary supplement in capsule form.

HY-P11262

GUB021794	GLP Receptor	Metabolic Disease
GUB021794 is a potent and highly selective glucagon-like peptide-1 receptor (GLP-1R) agonist developed using the streaMLine platform with an EC₅₀ value of 18 pM. GUB021794 has a very weak activity against SCTR, with an EC₅₀ value of 190 nM. GUB021794 can significantly reduce the body weight, food intake, and total fat mass of mice in a diet-induced obesity (DIO) model. GUB021794 can be used for research on obesity/diabetes .

HY-134577R

Clorprenaline (Standard)	Reference Standards Adrenergic Receptor	Endocrinology
Clorprenaline (Standard) is the analytical standard of Clorprenaline. This product is intended for research and analytical applications. Clorprenaline is a potent agonist of β2-adrenergic. Clorprenaline promotes animal muscular mass growth and decreases fat accumulation. Clorprenaline is a potential new lean meat-boosting feed additive .

HY-156405

FTO-IN-10	Fat Mass and Obesity-associated Protein (FTO) Autophagy	Metabolic Disease
FTO-IN-10 (compound 7) is a potent human demethylase FTO (the fat mass and obesity-associated protein) inhibitor with an IC₅₀ of 4.5 μM. FTO-IN-10 enters the FTO’s structural domain II binding pocket through hydrophobic and hydrogen bonding interactions. FTO-IN-10 induces DNA damage and autophagic cell death in A549 cells .

HY-139820

FTO-IN-4	Fat Mass and Obesity-associated Protein (FTO)	Neurological Disease Cancer
FTO-IN-4 is a potent and selective inhibitor of fat mass obesity-associated protein (FTO).

HY-165051

1,3-Dibutyryl-2-oleoyl glycerol 1,3-Butyrin-2-olein; TG(4:0/18:1/4:0)	Biochemical Assay Reagents	Others
1,3-Dibutyryl-2-oleoyl glycerol (1,3-Butyrin-2-olein) is a short-chain triglyceride compound in bovine milk fat. It was analyzed by specific chromatography-mass spectrometry techniques to determine its distribution and composition in bovine milk fat.

HY-19656

HMR1426	Biochemical Assay Reagents	Metabolic Disease
HMR1426 is an orally active, potent gastric emptying inhibitor. HMR1426 reduces food intake and the rate of gastric emptying, decreases body weight and fat mass and shows an anorectic potential in rats. HMR1426 has the potential for obesity research .

HY-161985

PPARγ-IN-3	PPAR	Metabolic Disease
PPARγ-IN-3 (compound 9ga) is a potent and orally active PPARγ inhibitor. PPARγ-IN-3 reduces triglyceride (TG) accumulation with low cytotoxicity. PPARγ-IN-3 preventes the excessive growth of body weight and lessened fat mass as well as liver mass, decreases lipid accumulation in the liver and blood. PPARγ-IN-3 has the potential for the research of diet-induced obesity .

HY-117275S1

Meclofenamic acid-13C6 Meclofenamate-¹³C₆	Isotope-Labeled Compounds Gap Junction Protein Endogenous Metabolite	Inflammation/Immunology
Meclofenamic acid- ¹³C₆ is the ¹³C₆ labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.

HY-165055

1-Oleoyl-2-palmitoyl-3-linoleoyl-rac-glycerol 1-Olein-2-palmitin-3-linolein; TG(18:1/16:0/18:2); 18:1/16:0/18:2-TG	Others	Others
1-Oleoyl-2-palmitoyl-3-linoleoyl-rac-glycerol (1-Olein-2-palmitin-3-linolein) is a compound mentioned in the chemical analysis of triglycerides and diacylglycerols in bovine milk fat. It was identified by a specific chromatography-mass spectrometry technique, which is environmentally friendly and efficient.

HY-117275S

Meclofenamic acid-d4 Meclofenamate-d₄	Isotope-Labeled Compounds Gap Junction Protein Endogenous Metabolite	Inflammation/Immunology
Meclofenamic acid-d₄ is the deuterium labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker .

HY-17462R

Adrenosterone (Standard) (+)-Adrenosterone (Standard)	Androgen Receptor Endogenous Metabolite Reference Standards	Endocrinology Cancer
Adrenosterone (Standard) is the analytical standard of Adrenosterone. This product is intended for research and analytical applications. Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .

HY-100935S

Cimaterol-d7 CL 263780-d₇	Isotope-Labeled Compounds Adrenergic Receptor	Endocrinology
Cimaterol-d₇ is the deuterium labeled Cimaterol. Cimaterol is a potent agonist of β-adrenergic receptors (pEC50s=8.13, 8.78, and 6.62 for human β1, β2, and β3, respectively). Cimaterol has been used in farmed animals to increase carcass mass and to alter muscle and fat deposition.

HY-N2840S

Allitol-13C Allodulcitol-¹³C	Isotope-Labeled Compounds	Metabolic Disease
Allitol (Allodulcitol)- ¹³C is the ¹³C labeled Allitol (HY-N2840). Allitol is an orally active rare sugar alcohol found in Itea virginica L, Tylopilus plumbeoviolaceus. Allitol has anti-obesity and hypoglycaemic activities. Allitol reduces carcass and total body fat mass, increases cecal weight, surface area, and short-chain fatty acid production, and upregulates cecal microbial enzymes linked to butyrate metabolism. Allitol can be used for the researches of obesity and diabetes .

HY-W759219

Adrenosterone-13C3 (+)-Adrenosterone-¹³C₃; 11-Keto-androstedione-¹³C₃	Isotope-Labeled Compounds Endogenous Metabolite Androgen Receptor	Endocrinology
Adrenosterone- ¹³C₃ ((+)-Adrenosterone- ¹³C₃) is the ¹³C-labeled Adrenosterone (HY-17462). Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .

HY-N2840R

Allitol (Standard) Allodulcitol (Standard)	Reference Standards	Metabolic Disease
Allitol (Allodulcitol) (Standard) is the analytical standard of Allitol (HY-N2840). This product is intended for research and analytical applications. Allitol is an orally active rare sugar alcohol found in Itea virginica L, Tylopilus plumbeoviolaceus. Allitol has anti-obesity and hypoglycaemic activities. Allitol reduces carcass and total body fat mass, increases cecal weight, surface area, and short-chain fatty acid production, and upregulates cecal microbial enzymes linked to butyrate metabolism. Allitol can be used for the researches of obesity and diabetes .

HY-11032

SM-350300	Others	Metabolic Disease
SM-350300 is a glucoprotein. SM-350300 stimulates lipolysis in white adipocytes by activating the cyclic AMP (cAMP) pathway, and upregulates the expression of lipolytic enzymes and uncoupling proteins (UCP1, UCP3) in brown adipose tissue (BAT) and white adipose tissue (WAT). SM-350300 reduces body weight by decreasing carcass fat while increasing lean muscle mass in metabolic disorder models. SM-350300 can be used for the study of metabolic disorders including obesity, type 2 diabetes, and cachexia .

HY-117275R

Meclofenamic acid (Standard) Meclofenamate (Standard)	Reference Standards Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite	Neurological Disease Metabolic Disease Inflammation/Immunology
Meclofenamic acid (Standard) is the analytical standard of Meclofenamic acid. This product is intended for research and analytical applications. Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively .

HY-113781

Ractopamine LY031537 free base	Adrenergic Receptor Trace Amine-associated Receptor (TAAR)	Metabolic Disease
Ractopamine (LY031537 free base) is a potent and orally active β-adrenergic receptor (βAR) agonist with K_d value of ~25 nM for pig β1AR and β2AR. Ractopamine also is a mTAAR1 agonist with an EC₅₀ of 16 μM. Ractopamine promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-172399

FTO-IN-14	Fat Mass and Obesity-associated Protein (FTO) Apoptosis	Cancer
FTO-IN-14 (Compound F97) is the inhibitor for the RNA demethylase Fat mass and obesity-associated protein FTO with IC₅₀ of 0.45 μM. FTO-IN-14 regulates the protein expression of ASB2, RARA and MYC. FTO-IN-14 exhibits antiproliferative activity in AML cancer cells (IC₅₀ for MOLM13, NB4, HEL, OCI-AML3, MV4-11 and MONOMAC6 is 0.7-5.5 μM), induces apoptosis in NB4 cell. FTO-IN-14 exhibits antitumor activity in mouse NB4 xenograft models .

HY-W751275

Ractopamine-13C2	Isotope-Labeled Compounds Adrenergic Receptor Trace Amine-associated Receptor (TAAR)	Metabolic Disease
Ractopamine- ¹³C₂ is the ¹³C-labeled Ractopamine (HY-113781). Ractopamine (LY031537 free base) is a potent and orally active β-adrenergic receptor (βAR) agonist with K_d value of ~25 nM for pig β1AR and β2AR. Ractopamine also is a mTAAR1 agonist with an EC₅₀ of 16 μM. Ractopamine promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-W751276

Ractopamine-13C6	Isotope-Labeled Compounds Adrenergic Receptor Trace Amine-associated Receptor (TAAR)	Metabolic Disease
Ractopamine- ¹³C₆ is the ¹³C-labeled Ractopamine (HY-113781). Ractopamine (LY031537 free base) is a potent and orally active β-adrenergic receptor (βAR) agonist with K_d value of ~25 nM for pig β1AR and β2AR. Ractopamine also is a mTAAR1 agonist with an EC₅₀ of 16 μM. Ractopamine promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-180642

THR-β modulator-3	Thyroid Hormone Receptor	Metabolic Disease
THR-β modulator-3 (Compound 75-2) is a THR-β modulator. THR-β modulator-3reduces total fat mass, body weight. THR-β modulator-3 improves obesity .

Cat. No.	Product Name	Type

HY-W127851

CLA

Cypridina luciferin analog

Biochemical Assay Reagents

CLA, or conjugated linoleic acid, is a polyunsaturated fatty acid that occurs naturally in a variety of animal products, such as meat and dairy. It has several potential benefits for human health, including the ability to reduce body fat mass, improve insulin sensitivity, and reduce inflammation. CLA has been extensively studied for its effects on weight loss and muscle growth, as well as its potential role in preventing chronic diseases such as heart disease and cancer. Additionally, it can be taken as a dietary supplement in capsule form.

Cat. No.	Product Name	Target	Research Area

HY-P10745

Petrelintide ZP8396	Amylin Receptor	Metabolic Disease
Petrelintide (ZP8396) is a dual amylin and calcitonin receptor agonist (DACRA) Petrelintide elicits a selective reduction in high-fat diet intake in diet-induced obese (DIO) rats, which is accompanied by a loss of fat mass and preservation of lean mass during weight reduction. Petrelintide can be utilized in diabetes research .

HY-P10745A

Petrelintide acetate ZP8396 acetate	Amylin Receptor	Metabolic Disease
Perelintide (ZP8396) acetate is a dual amylin and calcitonin receptor agonist (DACRA). Perelintide acetate elicits a selective reduction in high-fat diet intake in diet-induced obese (DIO) rats, which is accompanied by a loss of fat mass and preservation of lean mass during weight reduction. Perelintide acetate can be utilized in diabetes research .

HY-P11245A

NN1213 acetate	Amylin Receptor	Metabolic Disease
NN1213 acetate, a long-acting human amylin peptide analog, is a selective Amylin receptor agonist with EC₅₀ values of 0.177 and 0.262 nM for hAMY3R and rAMY3R, respectively. NN1213 acetate significantly reduces food intake and fat mass. NN1213 acetate can reduce body weightin diet-induced obese rats. NN1213 acetate can be used for the research of obesity .

HY-P11245

NN1213	Amylin Receptor	Metabolic Disease
NN1213, a long-acting human amylin peptide analog, is a selective Amylin receptor agonist with EC₅₀ values of 0.177 and 0.262 nM for hAMY3R and rAMY3R, respectively. NN1213 significantly reduces food intake and fat mass. NN1213 can reduce body weightin diet-induced obese rats. NN1213 can be used for the research of obesity .

HY-P11262

GUB021794	GLP Receptor	Metabolic Disease
GUB021794 is a potent and highly selective glucagon-like peptide-1 receptor (GLP-1R) agonist developed using the streaMLine platform with an EC₅₀ value of 18 pM. GUB021794 has a very weak activity against SCTR, with an EC₅₀ value of 190 nM. GUB021794 can significantly reduce the body weight, food intake, and total fat mass of mice in a diet-induced obesity (DIO) model. GUB021794 can be used for research on obesity/diabetes .

HY-P11587

BGM1812	Amylin Receptor CGRP Receptor	Metabolic Disease
BGM1812 is a dual agonist of amylin (hAMY3R) (EC₅₀ = 0.627 nM) and CGRP Receptor (hCTR) (EC₅₀ = 2.27 nM). BGM1812 achieves weight loss, increases the proportion of lean body mass, and reduces fat mass in diet-induced obese (DIO) rats. BGM1812 is applicable to research related to obesity .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991504

LAE-102	Anaplastic lymphoma kinase (ALK) TGF-β Receptor TGF-beta/Smad	Metabolic Disease Cancer
LAE-102 is the selective anti-ActRIIA (activin receptor type IIA or ACVR2) monoclonal antibody. LAE-102 increases muscle mass and reduces fat mass. LAE102 can increase serum activin A levels in vivo. LAE-102 is promising for research of obesity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-117275

Meclofenamic acid Maximum Cited Publications 8 Publications Verification Meclofenamate	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite
Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC₅₀ values of 56.0 and 155.9 μM, respectively .

HY-N6769

Radicicol 4 Publications Verification Monorden	Antifungal Classification of Application Fields Marine natural products Anti-parasitic Disease Research Infection Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Marine microorganism Disease Research Fields Source Classification	HSP Bacterial Antibiotic Parasite
Radicicol is an inhibitor of Hsp90 with an IC₅₀ value < 1 μM, and leads to proteasomal degradation . Radicicol exhibits inhibition on PDK with IC₅₀s of 230 μM (PDK1) and 400 μM (PDK3). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB . Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC₅₀ value of 16.04 μM .

HY-N1993

5-Methyl-7-methoxyisoflavone 3 Publications Verification	Flavonoids other families Classification of Application Fields Metabolic Disease Plants Disease Research Fields Isoflavones Source Classification	Cytochrome P450 NF-κB
5-Methyl-7-methoxyisoflavone is an orally active anti-oxidant with remyelinating activity. 5-Methyl-7-methoxyisoflavone inhibits the enzyme aromatase, interfering with the normal metabolic pathways of testosterone. 5-Methyl-7-methoxyisoflavone is a non-steroidal anabolic isoflavone, used as a anabolic agent. 5-Methyl-7-methoxyisoflavone shows better potency increasing muscle mass and endurance than Ipriflavone (HY-N0094). 5-Methyl-7-methoxyisoflavone can be used for fat loss besides the maintenance of low cholesterol level and strengthen bones. 5-Methyl-7-methoxyisoflavone is the inhibitor for NF-κB .

HY-N2840

Allitol 1 Publications Verification Allodulcitol	Structural Classification Natural Products Microorganisms Classification of Application Fields Metabolic Disease Disease Research Fields Sweeteners Source Classification Food Research	Others
Allitol (Allodulcitol) is an orally active rare sugar alcohol found in Itea virginica L, Tylopilus plumbeoviolaceus. Allitol has anti-obesity and hypoglycaemic activities. Allitol reduces carcass and total body fat mass, increases cecal weight, surface area, and short-chain fatty acid production, and upregulates cecal microbial enzymes linked to butyrate metabolism. Allitol can be used for the researches of obesity and diabetes .

HY-17462

Adrenosterone (+)-Adrenosterone	Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Androgen Receptor Endogenous Metabolite
Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .

HY-N10340

Clausine E Clauszoline I	Alkaloids Classification of Application Fields Rutaceae Plants Disease Research Fields Clausena harmandiana (Pierre) Guillaumin Cancer Source Classification	Others
Clausine E, is a alkaloid which can be isolated from Clausena excavata, is a inhibitor of fat mass and obesity-associated protein (FTO) demethylase. Clausine E shows inhibitory activities against proliferation of synoviocytes and cancer cells.

HY-117275A

Meclofenamic acid sodium hydrate Meclofenamate sodium hydrate	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite
Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selective gap-junction blocker. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC₅₀ values of 56.0 and 155.9 μM, respectively .

HY-17462R

Adrenosterone (Standard) (+)-Adrenosterone (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Androgen Receptor Endogenous Metabolite Reference Standards
Adrenosterone (Standard) is the analytical standard of Adrenosterone. This product is intended for research and analytical applications. Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .

HY-N2840R

Allitol (Standard) Allodulcitol (Standard)	Structural Classification Natural Products Microorganisms Source Classification	Reference Standards
Allitol (Allodulcitol) (Standard) is the analytical standard of Allitol (HY-N2840). This product is intended for research and analytical applications. Allitol is an orally active rare sugar alcohol found in Itea virginica L, Tylopilus plumbeoviolaceus. Allitol has anti-obesity and hypoglycaemic activities. Allitol reduces carcass and total body fat mass, increases cecal weight, surface area, and short-chain fatty acid production, and upregulates cecal microbial enzymes linked to butyrate metabolism. Allitol can be used for the researches of obesity and diabetes .

HY-117275R

Meclofenamic acid (Standard) Meclofenamate (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite
Meclofenamic acid (Standard) is the analytical standard of Meclofenamic acid. This product is intended for research and analytical applications. Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701888

	FTO Protein, Human (His) FTO; Alpha-ketoglutarate-dependent dioxygenase FTO; fat mass and obesity-associated protein; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; m6A(m)-demethylase FTO; mRNA N(6)-methyladenosine demethylase FTO; tRNA N1-methyl adenine demethylase FTO	Human	E. coli
	FTO protein is an RNA demethylase that regulates fat mass, lipogenesis, and energy homeostasis by targeting N(6)-methyladenosine in mRNA. It also demethylates m6A in U6 snRNA and m6A(m) in 5'-cap, affecting mRNA stability. FTO Protein, Human (His) is the recombinant human-derived FTO protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-W721874

Adrenosterone-d10

Adrenosterone-d₁₀ ((+)-Adrenosterone-d₁₀) is the deuterium labeled Adrenosterone (HY-17462). Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .

HY-117275S1

Meclofenamic acid-13C6
Meclofenamic acid- ¹³C₆ is the ¹³C₆ labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.

HY-117275S

Meclofenamic acid-d4
Meclofenamic acid-d₄ is the deuterium labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker .

HY-100935S

Cimaterol-d7
Cimaterol-d₇ is the deuterium labeled Cimaterol. Cimaterol is a potent agonist of β-adrenergic receptors (pEC50s=8.13, 8.78, and 6.62 for human β1, β2, and β3, respectively). Cimaterol has been used in farmed animals to increase carcass mass and to alter muscle and fat deposition.

HY-N2840S

Allitol-13C

Allitol (Allodulcitol)- ¹³C is the ¹³C labeled Allitol (HY-N2840). Allitol is an orally active rare sugar alcohol found in Itea virginica L, Tylopilus plumbeoviolaceus. Allitol has anti-obesity and hypoglycaemic activities. Allitol reduces carcass and total body fat mass, increases cecal weight, surface area, and short-chain fatty acid production, and upregulates cecal microbial enzymes linked to butyrate metabolism. Allitol can be used for the researches of obesity and diabetes .

HY-W759219

Adrenosterone-13C3

Adrenosterone- ¹³C₃ ((+)-Adrenosterone- ¹³C₃) is the ¹³C-labeled Adrenosterone (HY-17462). Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells .

HY-W751275

Ractopamine-13C2

Ractopamine- ¹³C₂ is the ¹³C-labeled Ractopamine (HY-113781). Ractopamine (LY031537 free base) is a potent and orally active β-adrenergic receptor (βAR) agonist with K_d value of ~25 nM for pig β1AR and β2AR. Ractopamine also is a mTAAR1 agonist with an EC₅₀ of 16 μM. Ractopamine promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-W751276

Ractopamine-13C6

Ractopamine- ¹³C₆ is the ¹³C-labeled Ractopamine (HY-113781). Ractopamine (LY031537 free base) is a potent and orally active β-adrenergic receptor (βAR) agonist with K_d value of ~25 nM for pig β1AR and β2AR. Ractopamine also is a mTAAR1 agonist with an EC₅₀ of 16 μM. Ractopamine promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

HY-B1421S2

Ractopamine-d3 hydrochloride

Ractopamine-d₃ (LY031537-d₃) hydrochloride is the deuterium labeled Ractopamine hydrochloride (HY-B1421). Ractopamine hydrochloride (LY031537) is a potent and orally active β-adrenergic receptor (βAR) agonist with K_d value of ~25 nM for pig β1AR and β2AR. Ractopamine hydrochloride also is a mTAAR1 agonist with an EC₅₀ of 16 μM. Ractopamine hydrochloride promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs .

Host:	Rabbit (3)
Reactivity:	Human (3) Rat (1) Mouse (1)
Application:	IHC-P (3) ICC/IF (1) IP (1) WB (3) ELISA (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80680

	FTO Antibody (YA424) FTO; KIAA1752; Alpha-ketoglutarate-dependent dioxygenase FTO; fat mass and obesity-associated protein	WB, IHC-P	Human
	FTO Antibody (YA424) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FTO.

HY-P86495

	FTO Antibody (YA6187) FTO; KIAA1752; Alpha-ketoglutarate-dependent dioxygenase FTO; fat mass and obesity-associated protein	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	FTO Antibody (YA6187) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FTO.

HY-P80680A

	FTO Antibody (YA424)(PBS only) FTO; KIAA1752; Alpha-ketoglutarate-dependent dioxygenase FTO; fat mass and obesity-associated protein	WB, IHC-P	Human
	FTO Antibody (YA424) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FTO.

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