Cat. No.: HY-N1993

5-Methyl-7-methoxyisoflavone

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

5-Methyl-7-methoxyisoflavone is an orally active anti-oxidant with remyelinating activity. 5-Methyl-7-methoxyisoflavone inhibits the enzyme aromatase, interfering with the normal metabolic pathways of testosterone. 5-Methyl-7-methoxyisoflavone is a non-steroidal anabolic isoflavone, used as a anabolic agent. 5-Methyl-7-methoxyisoflavone shows better potency increasing muscle mass and endurance than Ipriflavone (HY-N0094). 5-Methyl-7-methoxyisoflavone can be used for fat loss besides the maintenance of low cholesterol level and strengthen bones. 5-Methyl-7-methoxyisoflavone is the inhibitor for NF-κB.

For research use only. We do not sell to patients.

Purity: 99.13%
CAS No.: 82517-12-2
Formula: C₁₇H₁₄O₃
Molecular Weight:266.29

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

5-Methyl-7-methoxyisoflavone Chemical Structure

CAS No.: 82517-12-2

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Cytochrome P450 Isoforms :

All NF-κB Isoforms :

In Vitro

5-Methyl-7-methoxyisoflavone (10-40 μM, 7 days) inhibits the colony formation of HCT116 colon cancer cell with an inhibition rate of 55.3% (40 μM)^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 82517-12-2
Appearance Solid
Molecular Weight 266.29
Formula C₁₇H₁₄O₃
Color White to off-white
SMILES

O=C1C(C2=CC=CC=C2)=COC3=CC(OC)=CC(C)=C13
Structure Classification
- Flavonoids
- Isoflavones
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (3)

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Journal Impact Factor

Food Chem

Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]

2025 Dec 30:497:146992. PMID: 41285060
Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 Oct 15:489:144992. PMID: 40466530
Research Square Preprint

2021 Jan.

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (469.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.7553 mL

18.7765 mL

37.5530 mL

5 mM

0.7511 mL

3.7553 mL

7.5106 mL

10 mM

0.3755 mL

1.8777 mL

3.7553 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 6.25 mg/mL (23.47 mM); Clear solution

This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ningbo Gong, et al. Concomitant polymorphs of methoxyflavone (5-methyl-7-methoxyflavone). RSC Adv., 2016, 6, 38709-38715.

[2]. Agresti C, et al. Oxidative status in multiple sclerosis and off-targets of antioxidants: the case of edaravone[J]. Current Medicinal Chemistry, 2020, 27(13): 2095-2105. [Content Brief]

[3]. Iannone M, et al. An investigation on the metabolic pathways of synthetic isoflavones by gas chromatography coupled to high accuracy mass spectrometry. Rapid Commun Mass Spectrom. 2019 Oct 15;33(19):1485-1493. [Content Brief]

[4]. Lecompte Y, et al. UPLC-ESI-Q-TOF-MS(E) identification of urinary metabolites of the emerging sport nutrition supplement methoxyisoflavone in human subjects. J Pharm Biomed Anal. 2014 Aug 5;96:127-34. [Content Brief]

[5]. Lee S, et al., Isoflavone derivatives inhibit NF-κB-dependent transcriptional activity. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6277-81. [Content Brief]

[6]. Hyun J, et al., Isoflavones inhibit the clonogenicity of human colon cancer cells. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2664-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.7553 mL	18.7765 mL	37.5530 mL	93.8826 mL
	5 mM	0.7511 mL	3.7553 mL	7.5106 mL	18.7765 mL
	10 mM	0.3755 mL	1.8777 mL	3.7553 mL	9.3883 mL
	15 mM	0.2504 mL	1.2518 mL	2.5035 mL	6.2588 mL
	20 mM	0.1878 mL	0.9388 mL	1.8777 mL	4.6941 mL
	25 mM	0.1502 mL	0.7511 mL	1.5021 mL	3.7553 mL
	30 mM	0.1252 mL	0.6259 mL	1.2518 mL	3.1294 mL
	40 mM	0.0939 mL	0.4694 mL	0.9388 mL	2.3471 mL
	50 mM	0.0751 mL	0.3755 mL	0.7511 mL	1.8777 mL
	60 mM	0.0626 mL	0.3129 mL	0.6259 mL	1.5647 mL
	80 mM	0.0469 mL	0.2347 mL	0.4694 mL	1.1735 mL
	100 mM	0.0376 mL	0.1878 mL	0.3755 mL	0.9388 mL

Keywords

5-Methyl-7-methoxyisoflavone

3 Cited Publications

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5-Methyl-7-methoxyisoflavone

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Publications Citing Use of MedChemExpress (MCE) 5-Methyl-7-methoxyisoflavone

All Cytochrome P450 Isoforms

All NF-κB Isoforms

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

5-Methyl-7-methoxyisoflavone Related Classifications

HY-N1993 Related Classifications