FTO-IN-1
Based on 1 publication(s) in Google Scholar
FTO-IN-1 is a fat mass and obesity-associated enzyme (FTO) inhibitor extracted from patent WO2018157843A1, compound 32, with an IC50 of <1 μM. FTO-IN-1 can be used for the research of cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 2243944-92-3
- Formule: C18H16Cl2N4O2
- Masse moléculaire:391.25
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Publications Citing Use of MedChemExpress (MCE) FTO-IN-1
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Activité biologique
IC50: <1 μM (FTO)[1]
FTO-IN-1 (50 μM) inhibits FTO enzyme activity by 62% in vitro[1].
FTO-IN-1 (50 μM) inhibits the viability of SCLC-21H, RH30 and KP3 cells, with IC50s of 2.1 μM, 5.3 μM, and 5.6 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2243944-92-3
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Masse moléculaire 391.25
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Formule C18H16Cl2N4O2
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SMILES
O=C(NO)C1=CC=CC=C1NC2=C(Cl)C=C(C3=C(C)NN=C3C)C=C2Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Free Radic Biol Med
Hyperactivation of the m6A demethylase FTO to down-regulate SLC7A11/xCT-mediated redox homeostasis and epigenetic remodeling in facial infiltrating lipomatosis. [Abstract]2025 Nov:239:432-448. PMID: 40769313
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FTO-IN-1 Related Classifications
HY-138843 Related Classifications
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