2. GPCR/G Protein Neuronal Signaling
  3. Amylin Receptor CGRP Receptor
  4. BGM1812

BGM1812 is a dual agonist of amylin (hAMY3R) (EC50 = 0.627 nM) and CGRP Receptor (hCTR) (EC50 = 2.27 nM). BGM1812 achieves weight loss, increases the proportion of lean body mass, and reduces fat mass in diet-induced obese (DIO) rats. BGM1812 is applicable to research related to obesity.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

BGM1812

BGM1812 Chemical Structure

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BGM1812 Related Antibodies

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Description

BGM1812 is a dual agonist of amylin (hAMY3R) (EC50 = 0.627 nM) and CGRP Receptor (hCTR) (EC50 = 2.27 nM). BGM1812 achieves weight loss, increases the proportion of lean body mass, and reduces fat mass in diet-induced obese (DIO) rats. BGM1812 is applicable to research related to obesity[1].

In Vitro

BGM1812 (4-fold serial dilutions from 200 μM stock; 1 h) potently activates hAMY3R (EC50 = 0.627 nM) and hCTR (EC50 = 2.270 nM) in HEK-293 cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BGM1812 Related Antibodies
Parmacokinetics
Species Dose Route T1/2 Tmax Cmax AUC0-t AUC0-∞
Rat[1] 1 mg/kg s.c. 21.1 h 24 h 5303 ng/mL 264931 ng·h/mL 282265
In Vivo

BGM1812 (1 mg/kg; s.c.; single administration) exhibits persistent food intake suppression and body weight reduction effects in Sprague-Dawley rats[1].
BGM1812 (0.012-0.12 mg/kg; subcutaneous injection; once every 3 days; total 10 doses) achieves body weight reduction, dose-dependent weight loss, and favorable body composition changes (increased proportion of lean body mass, decreased fat mass) in diet-induced obesity (DIO) rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (male, 6-8 weeks old, 210-240 g)[1]
Dosage: 1 mg/kg
Administration: s.c.; single dose
Result: Had a sustained inhibitory effect on food intake, significantly reducing food intake 3-4 days after administration.
Reduced body weight, demonstrating a sustained weight loss advantage.
Animal Model: Sprague-Dawley (male, 20 weeks old, diet-induced obesity model)[1]
Dosage: 0.012 mg/kg; 0.04 mg/kg; 0.12 mg/kg
Administration: s.c.; every third day; 10 doses
Result: Reduced weight and food intake, increased lean body mass, and reduced fat mass.
Molecular Weight

4149.61

Formula

C182H299N49O61
Sequence

{γGlu-C20 diacid}-Arg-Asp-Gly-Thr-Ala-Thr-Lys-Ala-Thr-Glu-Arg-{αMeLeu}-Ala-{Aad}-Phe-Leu-Gln-Arg-Ser-Ser-Phe-{Sar}-Ala-{Sar}-Leu-Ser-Ser-Thr-Glu-Thr-Gly-Ser-Asn-Thr-{Hyp}-NH2 (Lactm bridge:Asp3-Lys8)
Sequence Shortening

{γGlu-C20 diacid}-RDGTATKATER-{αMeLeu}-A-{Aad}-FLQRSSF-{Sar}-A-{Sar}-LSSTETGSNT-{Hyp}-NH2 (Lactm bridge:Asp3-Lys8)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BGM1812 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BGM1812BGM 1812BGM-1812Amylin ReceptorCGRP ReceptorAMYRCalcitonin gene-related peptide receptorobesityHEK-293 cellsamylin 3 receptorhAMY?RSD ratsDIO ratshCTRcalcitonin receptorInhibitorinhibitorinhibit

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