BGM1812
Based on 1 Customer Validation
BGM1812 is a dual agonist of amylin (hAMY3R) (EC50 = 0.627 nM) and CGRP Receptor (hCTR) (EC50 = 2.27 nM). BGM1812 achieves weight loss, increases the proportion of lean body mass, and reduces fat mass in diet-induced obese (DIO) rats. BGM1812 is applicable to research related to obesity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.52%
- Fòrmula: C182H299N49O61
- Peso molecular:4149.61
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Almacenamiento:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
In Vitro
BGM1812 (4-fold serial dilutions from 200 μM stock; 1 h) potently activates hAMY3R (EC50 = 0.627 nM) and hCTR (EC50 = 2.270 nM) in HEK-293 cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | T1/2 | Tmax | Cmax | AUC0-t | AUC0-∞ |
|---|---|---|---|---|---|---|---|
| Rat[1] | 1 mg/kg | s.c. | 21.1 h | 24 h | 5303 ng/mL | 264931 ng·h/mL | 282265 |
In Vivo
BGM1812 (0.012-0.12 mg/kg; subcutaneous injection; once every 3 days; total 10 doses) achieves body weight reduction, dose-dependent weight loss, and favorable body composition changes (increased proportion of lean body mass, decreased fat mass) in diet-induced obesity (DIO) rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 6-8 weeks old, 210-240 g)[1]
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Dosage:1 mg/kg
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Administration:s.c.; single dose
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Result:Had a sustained inhibitory effect on food intake, significantly reducing food intake 3-4 days after administration.
Reduced body weight, demonstrating a sustained weight loss advantage.
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Animal Model:Sprague-Dawley (male, 20 weeks old, diet-induced obesity model)[1]
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Dosage:0.012 mg/kg; 0.04 mg/kg; 0.12 mg/kg
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Administration:s.c.; every third day; 10 doses
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Result:Reduced weight and food intake, increased lean body mass, and reduced fat mass.
Chemical Information
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Appearance Solid
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Peso molecular 4149.61
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Fòrmula C182H299N49O61
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Color White to off-white
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Sequence
{γGlu-C20 diacid}-Arg-Asp-Gly-Thr-Ala-Thr-Lys-Ala-Thr-Glu-Arg-{αMeLeu}-Ala-{Aad}-Phe-Leu-Gln-Arg-Ser-Ser-Phe-{Sar}-Ala-{Sar}-Leu-Ser-Ser-Thr-Glu-Thr-Gly-Ser-Asn-Thr-{Hyp}-NH2 (Lactm bridge:Asp3-Lys8)
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Sequence Shortening
{γGlu-C20 diacid}-RDGTATKATER-{αMeLeu}-A-{Aad}-FLQRSSF-{Sar}-A-{Sar}-LSSTETGSNT-{Hyp}-NH2 (Lactm bridge:Asp3-Lys8)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (24.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (295 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.2410 mL | 1.2049 mL | 2.4099 mL | 6.0247 mL |
| 5 mM | 0.0482 mL | 0.2410 mL | 0.4820 mL | 1.2049 mL | |
| 10 mM | 0.0241 mL | 0.1205 mL | 0.2410 mL | 0.6025 mL | |
| 15 mM | 0.0161 mL | 0.0803 mL | 0.1607 mL | 0.4016 mL | |
| 20 mM | 0.0120 mL | 0.0602 mL | 0.1205 mL | 0.3012 mL |
BGM1812 Related Classifications
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