FTO-IN-8
Based on 1 Customer Validation
FTO-IN-8 (FTO-43) is a N6-methyladenosine demethylase (FTO) (fat mass- and obesity-associated protein) inhibitor with the IC50 value of 5.5 μM. FTO-IN-8 has anti-cancer cell proliferative activity.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 95.04%
- CAS 番号: 2640366-38-5
- 分子式: C19H23ClN2O2
- 分子量:346.85
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保管条件:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| AGS | EC50 |
20.3 μM
Compound: FTO-43 N; TR-FTO-43 N
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Cytotoxicity against human AGS cells assessed as inhibition of proliferation measured after 24 to 72 hrs by CCK-8 assay
Cytotoxicity against human AGS cells assessed as inhibition of proliferation measured after 24 to 72 hrs by CCK-8 assay
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[PMID: 35939803] |
| CCD-841CoN | EC50 |
>50 μM
Compound: FTO-43 N; TR-FTO-43 N
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Cytotoxicity against human CCD-841CoN cells assessed as inhibition of proliferation measured after 24 to 72 hrs by CCK-8 assay
Cytotoxicity against human CCD-841CoN cells assessed as inhibition of proliferation measured after 24 to 72 hrs by CCK-8 assay
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[PMID: 35939803] |
| KATO III stomach cancer cell line | EC50 |
35.9 μM
Compound: FTO-43 N; TR-FTO-43 N
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Cytotoxicity against human KATO III stomach cancer cell line assessed as inhibition of proliferation measured after 24 to 72 hrs by CCK-8 assay
Cytotoxicity against human KATO III stomach cancer cell line assessed as inhibition of proliferation measured after 24 to 72 hrs by CCK-8 assay
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[PMID: 35939803] |
| SNU-16 | EC50 |
17.7 μM
Compound: FTO-43 N; TR-FTO-43 N
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Cytotoxicity against human SNU-16 cells assessed as inhibition of proliferation measured after 24 to 72 hrs by CCK-8 assay
Cytotoxicity against human SNU-16 cells assessed as inhibition of proliferation measured after 24 to 72 hrs by CCK-8 assay
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[PMID: 35939803] |
体外実験
FTO-IN-8 (FTO-43) (0-50 μM, 24-72 h) inhibits the proliferation of cancer cells with no cytotoxicity to normal colonic cells[1].
FTO-IN-8 (FTO-43) can increase m6A and m6Am levels and inhibits Wnt/PI3K-Akt signaling in gastric cancer AGS cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:AGS, SNU16, and KATOIII cell lines
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Concentration:0-50 μM
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Incubation Time:24, 48, 72 hours
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Result:Inhibited the growth of SNU16, KATOIII and AGS with the EC50 values of 17.7 μM, 35.9 μM and 20.3 μM, respectively.
化学情報
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CAS 番号 2640366-38-5
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性状 Oil
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分子量 346.85
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分子式 C19H23ClN2O2
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Color Light yellow to yellow
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SMILES
ClC1=CC=CC=C1C2=CC=C(CNCC3(N4CCCC4)COC3)O2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : ≥ 100 mg/mL (288.31 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
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データシート (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
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- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8831 mL | 14.4155 mL | 28.8309 mL | 72.0773 mL |
| 5 mM | 0.5766 mL | 2.8831 mL | 5.7662 mL | 14.4155 mL | |
| 10 mM | 0.2883 mL | 1.4415 mL | 2.8831 mL | 7.2077 mL | |
| 15 mM | 0.1922 mL | 0.9610 mL | 1.9221 mL | 4.8052 mL | |
| 20 mM | 0.1442 mL | 0.7208 mL | 1.4415 mL | 3.6039 mL | |
| 25 mM | 0.1153 mL | 0.5766 mL | 1.1532 mL | 2.8831 mL | |
| 30 mM | 0.0961 mL | 0.4805 mL | 0.9610 mL | 2.4026 mL | |
| 40 mM | 0.0721 mL | 0.3604 mL | 0.7208 mL | 1.8019 mL | |
| 50 mM | 0.0577 mL | 0.2883 mL | 0.5766 mL | 1.4415 mL | |
| 60 mM | 0.0481 mL | 0.2403 mL | 0.4805 mL | 1.2013 mL | |
| 80 mM | 0.0360 mL | 0.1802 mL | 0.3604 mL | 0.9010 mL | |
| 100 mM | 0.0288 mL | 0.1442 mL | 0.2883 mL | 0.7208 mL |
FTO-IN-8 関連分類
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