2. Search Result
Search Result
Results for "

genotoxic

" in MCE Product Catalog:

41

Inhibitors & Agonists

2

Fluorescent Dye

1

Peptides

13

Natural
Products

4

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas
  • HY-133647
    Dibromoacetaldehyde

    		Others Others
    Dibromoacetaldehyde, a halogenated product, is a byproduct in drinking water and has genotoxicity.
  • HY-133648
    Bromochloroacetaldehyde

    		Others Others
    Bromochloroacetaldehyde belongs to dihalogenated acetaldehyde and is a byproduct in drinking water. Bromochloroacetaldehyde has genotoxicity.
  • HY-133649
    Dibromochloroacetaldehyde

    		Others Others
    Dibromochloroacetaldehyde belongs to trihalogenated acetaldehyde and is a byproduct in drinking water. Dibromochloroacetaldehyde has genotoxicity.
  • HY-N2081
    Skimmianine

    		Others Cancer Inflammation/Immunology
    Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity.
  • HY-121345
    Homobaldrinal

    		Others Cancer Neurological Disease
    Homobaldrinal is a decomposition product of Valepotriate (HY-N0718). Homobaldrinal exhibits genotoxic activity in the Salmonella/microsome test.
  • HY-N8022
    Lucidin primeveroside

    Lucidin 3-O-β-primeveroside

    		 Biochemical Assay Reagents Cancer
    Lucidin primeveroside (Lucidin 3-O-β-primeveroside) is an anthraquinone derivative present in madder root, which has been used as a coloring agent and food additive. Lucidin primeveroside can be metabolically converted to genotoxic compound Lucidin, which subsequently forms lucidin-specific DNA adducts.
  • HY-146121
    Antitubercular agent-26

    		Bacterial Infection
    Antitubercular agent-26 (Compound 32) is an orally active anti-tubercular agent with an extracellular IC50 of 0.50 μM and an intracellular IC50 of 0.51 μM against M. tuberculosis H37Rv. Antitubercular agent-26 shows good metabolic stability, low risk of cardiotoxicity and no genotoxicity.
  • HY-151629
    MRV03-069

    		Others Cancer
    MRV03-069 (Compound 3) is a selective colibactin-activated peptidase (ClbP) inhibitor that blocks the genotoxic effect of Colibactin (HY-145930) on eukaryotic cells. MRV03-069 can be used in colorectal cancer research.
  • HY-151628
    MRV03-068

    		Others Cancer
    MRV03-068 (Compound 2) is a selective colibactin-activated peptidase (ClbP) inhibitor that blocks the genotoxic effect of Colibactin (HY-145930) on eukaryotic cells. MRV03-068 can be used in colorectal cancer research.
  • HY-119635
    Albicanol

    		Others Cancer
    Albicanol is a sesquiterpenoid with potent antioxidant and antagonistic activities against heavy metal toxicity. Albicanol shows cytotoxicity. Albicanol suppress profenofos (HY-B0832) induced genotoxicity in grass carp hepatocytes.
  • HY-133787
    Levofloxacin N-oxide

    		Drug Metabolite Infection
    Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330). Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria.
  • HY-125098
    Illudin S

    		DNA Alkylator/Crosslinker Apoptosis Cancer Infection
    Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells.
  • HY-W010553
    2,5-Dimethyl-3(2H)-furanone

    		Others Others
    2,5-Dimethyl-3(2H)-furanone is a flavouring substance without genotoxicity.
  • HY-124489
    2-Hydroxyestradiol

    		Endogenous Metabolite Metabolic Disease
    2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity.
  • HY-124489S1
    2-Hydroxyestradiol-d5

    		Endogenous Metabolite Infection
    2-Hydroxyestradiol-d5 is the deuterium labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[[1][3][4].
  • HY-124489S
    2-Hydroxyestradiol-13C6

    		Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    2-Hydroxyestradiol- 13C6 is the 13C-labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[1][3].
  • HY-Y0069
    N-Acetylglycine

    Aceturic acid; Acetamidoacetic acid

    		 Endogenous Metabolite Others
    N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics.
  • HY-136375
    Cyanazine

    		Others Others
    Cyanazine, a triazine herbicide cyanazine, is used to control a variety of grass weeds and broadleaf weed. Cyanazine is proved non-genotoxic.
  • HY-131102
    Mequindox

    		Bacterial DNA/RNA Synthesis Infection
    Mequindox is an antimicrobial agent. Mequindox acts as an inhibitor of DNA synthesis. Mequindox induces genotoxicity and carcinogenicity in mice.
  • HY-N4183
    Licoflavone C

    		Others Cancer
    Licoflavone C is a prenyl-flavone extracted from Genista ephedroides, reduces the genotoxicity of cancer drugs in human peripheral lymphocytes.
  • HY-145930
    Colibactin

    		DNA Alkylator/Crosslinker Cancer
    Colibactin is a complex secondary metabolite produced by some genotoxic gut Escherichia coli strains. Colibactin has the potential for the research of colorectal cancer[1].
  • HY-122099
    Riddelline

    		DNA/RNA Synthesis Others
    Riddelline, a pyrrolizidine alkaloid, is a potent genotoxic agent. Riddelline induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver.
  • HY-118948
    MSN-50

    		Bcl-2 Family Neurological Disease
    MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection.
  • HY-116108
    Musk tibetene

    Musk tibetine

    		 Others Cancer
    Musk tibetene (Musk tibetine) is a nitro musk compound with carcinogenic activity. Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell line.
  • HY-136375S
    Cyanazine-d5

    		Isotope-Labeled Compounds Others
    Cyanazine-d5 is deuterium labeled Cyanazine. Cyanazine, a triazine herbicide cyanazine, is used to control a variety of grass weeds and broadleaf weed. Cyanazine is proved non-genotoxic[1].
  • HY-Y0069S
    N-Acetylglycine-d5

    Aceturic acid-d5; Acetamidoacetic acid-d5

    		 Endogenous Metabolite
    N-Acetylglycine-d5 is the deuterium labeled N-Acetylglycine. N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics.
  • HY-125815
    Reactive Blue 4

    		Fluorescent Dye Others
    Reactive Blue 4 is an anthraquinone dye, as a single colorimetric chemosensor for sequential determination of multiple analytes with different optical responses in aqueous media. Reactive Blue 4 is phytotoxic, cytotoxic and genotoxic. Reactive Blue 4 .
  • HY-151626
    MRV03-037

    		Bacterial Infection
    MRV03-037 is a selective colibactin-activated peptidase (ClbP) inhibitor that blocks the genotoxic effect of Colibactin (HY-145930) on eukaryotic cells. MRV03-037 prevents gut bacterial genotoxin production.
  • HY-136440
    Hydroxymetronidazole

    Metronidazole-OH

    		 Bacterial Parasite Infection
    Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole can be used for the research of certain bacterial and protozoal diseases in poultry, swine dysentery and genital trichomoniasis in cattle.
  • HY-N6807
    Elemicin

    		Stearoyl-CoA Desaturase (SCD) Influenza Virus Cancer Infection
    Elemicin is a alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin is one of the main components in aromatic food and has antimicrobial, antioxidant, and antiviral activities. Elemicin possesses genotoxicity and carcinogenicity.
  • HY-N1094
    Verminoside

    		PARP MDM-2/p53 Inflammation/Immunology
    Verminoside is an iridoid isolated from Kigelia africana, exhibits anti-inflammatory and remarkable antioxidant activity with a radical-scavenging activity of 2.5 μg/mL. The genotoxicity of Verminoside on human lymphocytes is associated with elevated levels of PARP-1 and p53 proteins.
  • HY-D0342
    Disperse Red 1

    		Fluorescent Dye Others
    Disperse Red 1, an azobenzene derivative, is an azo textile dye extensively used for dyeing polyester fabrics in textile industry.
  • HY-W001189
    1,3-Dithiane

    		Bacterial Endogenous Metabolite Infection
    1,3-Dithiane is a protected formaldehyde anion equivalent that could serve as a useful labeled synthon. 1,3-Dithiane is also a sulfur-containing Maillard reaction products (MRPs) found in boiled beef extracts. 1,3-Dithiane shows a potent direct-acting mutagenicity toward S. typhimurium TA98 and TA100.
  • HY-139149
    NiCur

    		Histone Acetyltransferase Cancer
    NiCur is a potent and selective CBP histone acetyltransferase (HAT) inhibitor with an IC50 value of 0.35 μΜ. NiCur, which blocks CBP HAT activity and downregulates p53 activation upon genotoxic stress. NiCur can be used for performing mechanistic studies without affecting the expression of target proteins.
  • HY-152187
    Topoisomerase IIα-IN-5

    		Topoisomerase Apoptosis Others
    Topoisomerase IIα-IN-5 is a topoisomerase II (topo II) α catalytic inhibitor. Topoisomerase IIα-IN-5 intercalates into DNA and binds to the DNA minor groove. Topoisomerase IIα-IN-5 exhibits better efficacy and less genotoxicity than Etoposide (HY-13629).
  • HY-113466
    4-Hydroxynonenal

    4-HNE

    		 Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite Cancer Neurological Disease Cardiovascular Disease
    4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria.
  • HY-152775
    RK-701

    		Histone Methyltransferase Cancer
    RK-701 is an highly selective and non-genotoxic inhibitor of G9a with IC50 value of 23-27 nM. RK-701 selectively up-regulates HbF, γ- Globin, BGLT3 expression, down-regulates H3K9me2 expression. RK-701 also has inhibition for BCL11A and ZBTB7A.
  • HY-14392
    5,6-Dichlorobenzimidazole riboside

    DRB

    		 CDK Cancer
    5,6-Dichlorobenzimidazole riboside is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II and CDKs. 5,6-Dichlorobenzimidazole riboside trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells.
  • HY-W006566
    5-AIQ

    5-Aminoisoquinolin-1-one

    		 PARP Cancer
    5-AIQ (5-Aminoisoquinolin-1-one) is a water-soluble PARP-1 inhibitor. 5-AIQ is an important functional group in various drugs. 5-AIQ reduces the tissue injury associated with ischemia-reperfusion of the liver, it can be used for the research of the therapy conditions associated with ischemia-reperfusion of the liver.
  • HY-137316
    Phosphoramide mustard

    		DNA Alkylator/Crosslinker Drug Metabolite Cancer
    Phosphoramide mustard is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard induces DNA damage.
  • HY-137316A
    Phosphoramide mustard (cyclohexanamine)

    		DNA Alkylator/Crosslinker Drug Metabolite Cancer
    Phosphoramide mustard cyclohexanamine is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA damage.