Antitubercular agent-26
Antitubercular agent-26 (Compound 32) is an orally active anti-tubercular agent with an extracellular IC50 of 0.50 μM and an intracellular IC50 of 0.51 μM against M. tuberculosis H37Rv. Antitubercular agent-26 shows good metabolic stability, low risk of cardiotoxicity and no genotoxicity.
For research use only. We do not sell to patients.
- CAS No.: 1845720-46-8
- Formula: C22H23N5O3S2
- Molecular Weight:469.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>50 μM
Compound: 32
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Cytotoxicity against human A549 cells assessed as inhibition of cell growth
Cytotoxicity against human A549 cells assessed as inhibition of cell growth
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[PMID: 33075682] |
| HEK293 | IC50 |
>50 μM
Compound: 32
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Cytotoxicity against HEK293 cells assessed as inhibition of cell growth
Cytotoxicity against HEK293 cells assessed as inhibition of cell growth
|
[PMID: 33075682] |
| HepG2 | IC50 |
>50 μM
Compound: 32
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Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth
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[PMID: 33075682] |
| Jurkat | IC50 |
>50 μM
Compound: 32
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Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth
Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth
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[PMID: 33075682] |
Chemical Information
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CAS No. 1845720-46-8
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Molecular Weight 469.58
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Formula C22H23N5O3S2
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SMILES
O=C(C(S1)=CC2=C1N=C(N3CCC(C(N(C)C)=O)CC3)S2)NC4=CC=C(OC(C)=N5)C5=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Genotoxicity/Mutagenicity Study
The bacterial reverse mutation assay detects point mutations that restore amino-acid prototrophy in auxotrophic Salmonella typhimurium or Escherichia coli tester strains; after exposure to a test article, mutagenic activity is read out as an increased number of revertant colonies on minimal agar compared with the vehicle control. The assay uses tester strains with different mutation targets so that base-substitution and frameshift mutagens can be detected, and testing is performed with and without exogenous mammalian metabolic activation because some chemicals require biotransformation to become mutagenic.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitubercular agent-26 Related Classifications
HY-146121 Related Classifications
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