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Cat. No.: HY-146121

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Antitubercular agent-26

Antitubercular agent-26 (Compound 32) is an orally active anti-tubercular agent with an extracellular IC₅₀ of 0.50 μM and an intracellular IC₅₀ of 0.51 μM against M. tuberculosis H37Rv. Antitubercular agent-26 shows good metabolic stability, low risk of cardiotoxicity and no genotoxicity.

For research use only. We do not sell to patients.

CAS No.: 1845720-46-8
Formula: C₂₂H₂₃N₅O₃S₂
Molecular Weight:469.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Antitubercular agent-26 Chemical Structure

CAS No.: 1845720-46-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>50 μM Compound: 32	Cytotoxicity against human A549 cells assessed as inhibition of cell growth Cytotoxicity against human A549 cells assessed as inhibition of cell growth	[PMID: 33075682]
HEK293	IC₅₀	>50 μM Compound: 32	Cytotoxicity against HEK293 cells assessed as inhibition of cell growth Cytotoxicity against HEK293 cells assessed as inhibition of cell growth	[PMID: 33075682]
HepG2	IC₅₀	>50 μM Compound: 32	Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth	[PMID: 33075682]
Jurkat	IC₅₀	>50 μM Compound: 32	Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth	[PMID: 33075682]

Chemical Information

CAS No. 1845720-46-8
Molecular Weight 469.58
Formula C₂₂H₂₃N₅O₃S₂
SMILES

O=C(C(S1)=CC2=C1N=C(N3CCC(C(N(C)C)=O)CC3)S2)NC4=CC=C(OC(C)=N5)C5=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jin G, et al. Discovery of thienothiazolocarboxamide analogues as novel anti-tubercular agent. Bioorg Med Chem. 2020 Dec 1;28(23):115797. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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