Search Result

Results for "

mc3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Melanocortin Receptor (25) ADC Linker (1) AP-1 (1) Complement System (1) DNA/RNA Synthesis (1) Drug-Linker Conjugates for ADC (1) GnRH Receptor (1) Isotope-Labeled Compounds (2) Liposome (4) mGluR (1) NF-κB (1) PD-1/PD-L1 (1) Phosphatase (1) Prostaglandin Receptor (1) RAR/RXR (2) Reference Standards (2) Small Interfering RNA (siRNA) (3) Toll-like Receptor (TLR) (1) VD/VDR (1) Wnt (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (3) Endocrinology (3) Infection (1) Inflammation/Immunology (11) Metabolic Disease (12) Neurological Disease (8)
Click Chemistry:	Azide (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Cationic Lipids (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Targets Recommended: Melanocortin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112251

*D-Lin-MC3-DMA* 145+ Cited Publications	Liposome	Cancer
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

HY-10624

THIQ 1 Publications Verification	Melanocortin Receptor	Metabolic Disease
THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC₅₀=1.2 nM, EC₅₀=2.1 nM) and rMC4R (IC₅₀=0.6 nM, EC₅₀=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants .

HY-P0227

SHU 9119 3 Publications Verification	Melanocortin Receptor	Metabolic Disease
SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC₅₀ values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively.

HY-N0123

Aloin-A 5+ Cited Publications Barbaloin-A	Wnt	Cancer
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) ^[3] .

HY-122808

(-)-Camphoric acid	mGluR NF-κB AP-1	Metabolic Disease
(-)-Camphoric acid is the less active enantiomer of Camphoric acid. Camphoric acid induces glutamate receptor expression. Camphoric acid also significantly induces the activation of NF-κB and AP-1. Camphoric acid significantly stimulates the differentiation of mouse osteoblastic MC3T3-E1 subclone 4 cells. Camphoric acid has weak regulatory function towards glutamate receptors. Camphoric acid can induce mRNA expression of glutamate signaling molecules and activate transcription factors, thereby stimulating osteoblast differentiation .

HY-147301A

Resomelagon acetate AP1189 acetate	Melanocortin Receptor	Metabolic Disease Inflammation/Immunology
Resomelagon (AP1189) acetate is a potent, orally active melanocortin receptor (MR) agonist about MC₁ and MC₃. Resomelagon acetate induces ERK1/2 phosphorylation and Ca ²⁺ mobilization. Resomelagon acetate has anti-inflammatory activity. Resomelagon acetate can be used for obesity and chronic inflammation research .

HY-147301

Resomelagon AP1189	Melanocortin Receptor	Metabolic Disease Inflammation/Immunology
Resomelagon (AP1189) is a potent, orally active melanocortin receptor (MR) agonist about MC₁ and MC₃. Resomelagon induces ERK1/2 phosphorylation and Ca ²⁺ mobilization. Resomelagon has anti-inflammatory activity. Resomelagon can be used for obesity and chronic inflammation research .

HY-115644

BMS-470539 dihydrochloride	Melanocortin Receptor	Inflammation/Immunology
BMS-470539 dihydrochloride is a highly potent and selective melanocortin-1 receptor (MC-1R) agonist with an IC₅₀ of 120 nM, an EC₅₀ of 28 nM. BMS-470539 dihydrochloride does not activate MC-3R and is a very weak partial agonist at MC-4R and MC-5R. BMS-470539 dihydrochloride has potently anti-inflammatory properties ^[3].

HY-P1531

γ-1-Melanocyte Stimulating Hormone (MSH), amide	Melanocortin Receptor	Cardiovascular Disease Metabolic Disease Endocrinology
γ-1-Melanocyte Stimulating Hormone (MSH), amide is a 11-amino acid peptide. γ-1-Melanocyte Stimulating Hormone (MSH) regulates sodium (Na ⁺) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R).

HY-P1215A

HS024 TFA 1 Publications Verification	Melanocortin Receptor	Metabolic Disease
HS024 is a selective MC4 receptor antagonist, with K_is of 0.29, 3.29, 5.45, 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake .

HY-112251GL

D-Lin-MC3-DMA (GMP Like)	Liposome	Cancer
D-Lin-MC3-DMA (GMP Like) is the GMP Like class D-Lin-MC3-DMA (HY-112251). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

HY-P1213

JKC363	Melanocortin Receptor	Neurological Disease
JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC₅₀=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect .

HY-P1214

γ1-MSH	Melanocortin Receptor	Cardiovascular Disease
γ1-MSH is a *melanocortin MC3* receptor agonist, with a K_i** of 34 nM for the rat MC3 receptor. γ1-MSH displays ~40-fold selectivity over MC4 (K_i=1318 nM) .

HY-P1217

[D-Trp8]-γ-MSH	Melanocortin Receptor	Inflammation/Immunology
[D-Trp8]-γ-MSH is a potent and selective agonist of *melanocortin 3 (MC3) receptor, with IC₅₀s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4* and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH could provide protection against multiple inflammatory disorders such as rheumatoid arthritis and colitis .

HY-112251S

*D-Lin-MC3-DMA-13C3*	Isotope-Labeled Compounds	Others
D-Lin-MC3-DMA- ¹³C₃ is the ¹³C labeled D-Lin-MC3-DMA. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle .

HY-108531

ER 50891	RAR/RXR	Metabolic Disease
ER 50891 is a RARα antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis .

HY-P2242A

RO27-3225 TFA	Melanocortin Receptor	Neurological Disease Inflammation/Immunology
RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC₅₀ of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects ^[3].

HY-P1215

HS024	Melanocortin Receptor	Metabolic Disease
HS024 is a selective MC4 receptor antagonist, with K_is of 0.29, 3.29, 5.45, and 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake .

HY-P3605

GnRH Associated Peptide (25-53), human GAP (25-53), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (25-53), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 25-53 fragment (hGAP-25-53), can be used as immunogen to generate antiseras including MC-1, MC-2, and MC-3. GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site .

HY-P1216

HS014	Melanocortin Receptor	Neurological Disease
HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with K_is of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats ^[3].

HY-P1640

(Trp63,Trp64)-C3a(63-77)	Complement System	Inflammation/Immunology
(Trp63,Trp64)-C3a(63-77) is a C3a synthetic analogue peptide, which exhibits Ca ²⁺ stimulating efficacy in human neutrophils and hC3aR or mC3aR expressing RBL-2H3 cells with EC₅₀ of 9.5, 2.0 and 0.8 nM, respectively .

HY-N11038

Drynachromoside A	Others	Others
Drynachromoside A is a chromone glycoside. Drynachromoside A has biochemical effects on the osteoblastic (MC3T3-E1 cells) proliferation activities .

HY-P1216A

HS014 TFA 1 Publications Verification	Melanocortin Receptor	Neurological Disease
HS014 TFA is a potent and selective melanocortin-4 (MC4) receptor antagonist, with K_is of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors respectively. HS014 TFA increases food intake in free-feeding rats .

HY-P0252B

α-MSH free acid α-Melanocyte-Stimulating Hormone free acid	Melanocortin Receptor	Neurological Disease
α-MSH free acid (α-Melanocyte-Stimulating Hormone free acid) is an *MC3R* and MC4R agonist with EC₅₀s of 0.16 nM and 5.6 nM, respectively. α-MSH free acid activates cAMP generation at MC3R and MC4R .

HY-P1213A

JKC363 TFA	Melanocortin Receptor	Neurological Disease
JKC363 TFA, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC₅₀=0.5 nM) than at the MC3 receptor (44.9 nM). JKC363 TFA blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect .

HY-144497

HE-S2	PD-1/PD-L1 Toll-like Receptor (TLR) Drug-Linker Conjugates for ADC	Infection Cancer
HE-S2 is an antibody-drug conjugate triggering a potent antitumor immune response. HE-S2 acts by blocking the PD-1/PD-L1 interaction and activating the Toll-like receptor 7/8 (TLR7/8) signaling pathway. HE-S2 has remarkable antitumor activity .

HY-108531A

ER 50891 quarterhydrate	RAR/RXR	Cancer
ER 50891 quarterhydrate is a RARα antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis .

HY-P2242

RO27-3225	Melanocortin Receptor	Neurological Disease Inflammation/Immunology
RO27-3225 is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC₅₀ of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 shows 30-fold selectivity for MC4R over MC3R. RO27-3225 has neuroprotective and anti-inflammatory effects ^[3].

HY-151738

Fmoc-Aeg(N3)-OH	ADC Linker	Others
Fmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis . Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-P1214A

γ1-MSH TFA	Melanocortin Receptor	Cardiovascular Disease
γ1-MSH TFA is a *melanocortin MC3* receptor agonist, with a K_i** of 34 nM for the rat MC3 receptor. γ1-MSH TFA displays ~40-fold selectivity over MC4 (K_i=1318 nM) .

HY-P1217A

[D-Trp8]-γ-MSH TFA	Melanocortin Receptor	Inflammation/Immunology
[D-Trp8]-γ-MSH TFA is a potent and selective agonist of *melanocortin 3 (MC3) receptor, with IC₅₀s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4* and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH TFA could provide protection against multiple inflammatory disorders such as rheumatoid arthritis and colitis .

HY-RS08206

MC3R Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Melanocortin Receptor	Others
MC3R Human Pre-designed siRNA Set A contains three designed siRNAs for MC3R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MC3R Human Pre-designed siRNA Set A MC3R Human Pre-designed siRNA Set A

HY-112251S1

*D-Lin-MC3-DMA-d6*	Isotope-Labeled Compounds Liposome	Cancer
D-Lin-MC3-DMA-d₆ is the deuterium labeled D-Lin-MC3-DMA (HY-112251). D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

HY-185010

nor-MC3	Liposome	Others
nor-MC3 is an ionizable lipid that can be used to prepare siRNA, mRNA and other drug delivery vectors .

HY-N0123R

Aloin-A (Standard) Barbaloin-A (Standard)	Reference Standards Wnt	Cancer
Aloin (Standard) is the analytical standard of Aloin. This product is intended for research and analytical applications. Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) ^[3] .

HY-11073

MK-0489	Melanocortin Receptor	Metabolic Disease
MK-0489 is an orally active, highly effective, and selective MC4R agonist. MK-0489 exhibits a strong binding affinity (IC₅₀ = 13 nM) and functional agonist activity (EC₅₀ = 4.6 nM) at human MC4R. MK-0489 shows functional activity of 22 nM (EC₅₀) on mouse MC4R and 1.7 μM (EC₅₀) on mouse MC3R. MK-0489 can be used for the study of obesity .

HY-RS08208

Mc3r Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Melanocortin Receptor	Others
Mc3r Rat Pre-designed siRNA Set A contains three designed siRNAs for Mc3r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mc3r Rat Pre-designed siRNA Set A Mc3r Rat Pre-designed siRNA Set A

HY-RS08207

Mc3r Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Melanocortin Receptor	Others
Mc3r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc3r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mc3r Mouse Pre-designed siRNA Set A Mc3r Mouse Pre-designed siRNA Set A

HY-N14645

Ipolamiide	Phosphatase	Metabolic Disease
Ipolamiide is an antiosteoporotic agent that can be isolated from Barleria lupulina. Ipolamiide exhibits a potent antiosteoporotic effect. Ipolamiide dose-dependently enhances alkaline phosphatase (ALP) activity in MC3T3-E1 cells. Ipolamiide can be used for osteoporosis research .

HY-105953

Froxiprost ONO-995	Prostaglandin Receptor	Endocrinology
Froxiprost (ONO-995) is a PGF2α (HY-12956) analogue. Froxiprost stimulates thymidine uptake, 1,2 diacylglycerol (1,2-DAG) accumulation, and phosphorylcholine formation in osteoblast-like MC3T3-E1 cells .

HY-N14021

Petasites japonicus extract	DNA/RNA Synthesis	Neurological Disease Inflammation/Immunology Cancer
Petasites japonicus extract is the extract from Petasites japonicus with antioxidant, anti-inflammatory, anti-obesity, neuroprotective and anti-cancer effects. Petasites japonicus extract promotes osteoblast differentiation via up-regulation of Runx2 and Osterix in MC3T3-E1 cells .

HY-170975

UG-650	VD/VDR	Cancer
UG-650 is a non-Gemini analog of UVB1 that combines the structural features of UVB1 and MC 1288. UG-650 can bind to the vitamin D receptor (VDR) and inhibit the proliferation of MCF-7 cells and the migration of MC3T3-E1 cells .

HY-168383

(E/Z)-Resomelagon acetate (E/Z)-AP1189 acetate	Melanocortin Receptor	Inflammation/Immunology
(E/Z)-Resomelagon acetate is an agonist of melanocortin receptor 1 (MC1R) and *MC3R* with anti-inflammatory activities. (E/Z)-Resomelagon can be utilized in inflammation research .

HY-N17139

6'-O-Glucopyranosylalbiflorin	Others	Inflammation/Immunology
6'-O-Glucopyranosylalbiflorin is a monoterpene glycoside compound containing two β-D-glucose units, which has bone formation-promoting effects. 0.01-10 μM 6'-O-Glucopyranosylalbiflorin shows significant activity against osteoblast MC3T3-E1 cells, promoting alkaline phosphatase activity and calcium deposition to stimulate osteoblast differentiation. 6'-O-Glucopyranosylalbiflorin can be used in research of osteoporosis. 6'-O-Glucopyranosylalbiflorin can be naturally extracted from the dried roots of Paeonia lactiflora Pall. (peony) from Vinh Phuc province, Vietnam .

HY-10624R

THIQ (Standard)	Reference Standards Melanocortin Receptor	Metabolic Disease
THIQ (Standard) is the analytical standard of THIQ (HY-10624). This product is intended for research and analytical applications. THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC₅₀=1.2 nM, EC₅₀=2.1 nM) and rMC4R (IC₅₀=0.6 nM, EC₅₀=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants .

Cat. No.	Product Name	Type

HY-112251

*D-Lin-MC3-DMA* 145+ Cited Publications	Biochemical Assay Reagents
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

HY-112251GL

D-Lin-MC3-DMA (GMP Like)	Biochemical Assay Reagents
D-Lin-MC3-DMA (GMP Like) is the GMP Like class D-Lin-MC3-DMA (HY-112251). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

Cat. No.	Product Name	Target	Research Area

HY-P0227

SHU 9119 3 Publications Verification	Melanocortin Receptor	Metabolic Disease
SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC₅₀ values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively.

HY-P1531

γ-1-Melanocyte Stimulating Hormone (MSH), amide	Melanocortin Receptor	Cardiovascular Disease Metabolic Disease Endocrinology
γ-1-Melanocyte Stimulating Hormone (MSH), amide is a 11-amino acid peptide. γ-1-Melanocyte Stimulating Hormone (MSH) regulates sodium (Na ⁺) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R).

HY-P1215A

HS024 TFA 1 Publications Verification	Melanocortin Receptor	Metabolic Disease
HS024 is a selective MC4 receptor antagonist, with K_is of 0.29, 3.29, 5.45, 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake .

HY-P1213

JKC363	Melanocortin Receptor	Neurological Disease
JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC₅₀=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect .

HY-P1214

γ1-MSH	Melanocortin Receptor	Cardiovascular Disease
γ1-MSH is a *melanocortin MC3* receptor agonist, with a K_i** of 34 nM for the rat MC3 receptor. γ1-MSH displays ~40-fold selectivity over MC4 (K_i=1318 nM) .

HY-P1217

[D-Trp8]-γ-MSH	Melanocortin Receptor	Inflammation/Immunology
[D-Trp8]-γ-MSH is a potent and selective agonist of *melanocortin 3 (MC3) receptor, with IC₅₀s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4* and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH could provide protection against multiple inflammatory disorders such as rheumatoid arthritis and colitis .

HY-P2242A

RO27-3225 TFA	Melanocortin Receptor	Neurological Disease Inflammation/Immunology
RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC₅₀ of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects ^[3].

HY-P1215

HS024	Melanocortin Receptor	Metabolic Disease
HS024 is a selective MC4 receptor antagonist, with K_is of 0.29, 3.29, 5.45, and 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake .

HY-P3605

GnRH Associated Peptide (25-53), human GAP (25-53), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (25-53), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 25-53 fragment (hGAP-25-53), can be used as immunogen to generate antiseras including MC-1, MC-2, and MC-3. GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site .

HY-P1216

HS014	Melanocortin Receptor	Neurological Disease
HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with K_is of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats ^[3].

HY-P1640

(Trp63,Trp64)-C3a(63-77)	Complement System	Inflammation/Immunology
(Trp63,Trp64)-C3a(63-77) is a C3a synthetic analogue peptide, which exhibits Ca ²⁺ stimulating efficacy in human neutrophils and hC3aR or mC3aR expressing RBL-2H3 cells with EC₅₀ of 9.5, 2.0 and 0.8 nM, respectively .

HY-P1216A

HS014 TFA 1 Publications Verification	Melanocortin Receptor	Neurological Disease
HS014 TFA is a potent and selective melanocortin-4 (MC4) receptor antagonist, with K_is of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors respectively. HS014 TFA increases food intake in free-feeding rats .

HY-P0252B

α-MSH free acid α-Melanocyte-Stimulating Hormone free acid	Melanocortin Receptor	Neurological Disease
α-MSH free acid (α-Melanocyte-Stimulating Hormone free acid) is an *MC3R* and MC4R agonist with EC₅₀s of 0.16 nM and 5.6 nM, respectively. α-MSH free acid activates cAMP generation at MC3R and MC4R .

HY-P1213A

JKC363 TFA	Melanocortin Receptor	Neurological Disease
JKC363 TFA, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC₅₀=0.5 nM) than at the MC3 receptor (44.9 nM). JKC363 TFA blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect .

HY-P2242

RO27-3225	Melanocortin Receptor	Neurological Disease Inflammation/Immunology
RO27-3225 is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC₅₀ of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 shows 30-fold selectivity for MC4R over MC3R. RO27-3225 has neuroprotective and anti-inflammatory effects ^[3].

HY-P1214A

γ1-MSH TFA	Melanocortin Receptor	Cardiovascular Disease
γ1-MSH TFA is a *melanocortin MC3* receptor agonist, with a K_i** of 34 nM for the rat MC3 receptor. γ1-MSH TFA displays ~40-fold selectivity over MC4 (K_i=1318 nM) .

HY-P1217A

[D-Trp8]-γ-MSH TFA	Melanocortin Receptor	Inflammation/Immunology
[D-Trp8]-γ-MSH TFA is a potent and selective agonist of *melanocortin 3 (MC3) receptor, with IC₅₀s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4* and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH TFA could provide protection against multiple inflammatory disorders such as rheumatoid arthritis and colitis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0123

Aloin-A 5+ Cited Publications Barbaloin-A	Quinones Structural Classification Liliaceae Classification of Application Fields Anthraquinones Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Disease Research Fields Source Classification Cancer	Wnt
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) ^[3] .

HY-122808

(-)-Camphoric acid	Classification of Application Fields Ketones, Aldehydes, Acids Cinnamomum glanduliferum (Wall.) Nees Metabolic Disease Plants Lauraceae Disease Research Fields Source Classification	mGluR NF-κB AP-1
(-)-Camphoric acid is the less active enantiomer of Camphoric acid. Camphoric acid induces glutamate receptor expression. Camphoric acid also significantly induces the activation of NF-κB and AP-1. Camphoric acid significantly stimulates the differentiation of mouse osteoblastic MC3T3-E1 subclone 4 cells. Camphoric acid has weak regulatory function towards glutamate receptors. Camphoric acid can induce mRNA expression of glutamate signaling molecules and activate transcription factors, thereby stimulating osteoblast differentiation .

HY-N11038

Drynachromoside A	Drynaria roosii Nakaike Flavonoids Polypodiaceae Plants Other Flavonoids Source Classification	Others
Drynachromoside A is a chromone glycoside. Drynachromoside A has biochemical effects on the osteoblastic (MC3T3-E1 cells) proliferation activities .

HY-N0123R

Aloin-A (Standard) Barbaloin-A (Standard)	Quinones Structural Classification Liliaceae Anthraquinones Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Source Classification	Reference Standards Wnt
Aloin (Standard) is the analytical standard of Aloin. This product is intended for research and analytical applications. Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI) ^[3] .

HY-N14645

Ipolamiide	Structural Classification Iridoids Acanthaceae Satureja hortensisL. Terpenoids Plants Source Classification	Phosphatase
Ipolamiide is an antiosteoporotic agent that can be isolated from Barleria lupulina. Ipolamiide exhibits a potent antiosteoporotic effect. Ipolamiide dose-dependently enhances alkaline phosphatase (ALP) activity in MC3T3-E1 cells. Ipolamiide can be used for osteoporosis research .

HY-N14021

Petasites japonicus extract	Natural Products Plants Compositae Piptadenia Benth. Source Classification	DNA/RNA Synthesis
Petasites japonicus extract is the extract from Petasites japonicus with antioxidant, anti-inflammatory, anti-obesity, neuroprotective and anti-cancer effects. Petasites japonicus extract promotes osteoblast differentiation via up-regulation of Runx2 and Osterix in MC3T3-E1 cells .

HY-N17139

6'-O-Glucopyranosylalbiflorin	Structural Classification Flavonoids Paeonia lactiflora Pall. Flavones Plants Paeoniaceae Source Classification	Others
6'-O-Glucopyranosylalbiflorin is a monoterpene glycoside compound containing two β-D-glucose units, which has bone formation-promoting effects. 0.01-10 μM 6'-O-Glucopyranosylalbiflorin shows significant activity against osteoblast MC3T3-E1 cells, promoting alkaline phosphatase activity and calcium deposition to stimulate osteoblast differentiation. 6'-O-Glucopyranosylalbiflorin can be used in research of osteoporosis. 6'-O-Glucopyranosylalbiflorin can be naturally extracted from the dried roots of Paeonia lactiflora Pall. (peony) from Vinh Phuc province, Vietnam .

Cat. No.	Product Name	Chemical Structure

HY-112251S

*D-Lin-MC3-DMA-13C3*
D-Lin-MC3-DMA- ¹³C₃ is the ¹³C labeled D-Lin-MC3-DMA. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle .

HY-112251S1

*D-Lin-MC3-DMA-d6*
D-Lin-MC3-DMA-d₆ is the deuterium labeled D-Lin-MC3-DMA (HY-112251). D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (4) Rat (2)
Application:	IHC-P (2) ICC/IF (2) IP (2) WB (4) FC (2) ELISA (2)
Isotype:	IgG (2) IgG2a (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84344

	RISP Antibody (YA4041) RIP1; RIS1; RISP; UQCR5; mc3DN10	WB, ICC/IF, FC, ELISA	Human
	RISP Antibody (YA4041) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to RISP.

HY-P84344A

	RISP Antibody (YA4041)(PBS only) RIP1; RIS1; RISP; UQCR5; mc3DN10	WB, ICC/IF, FC, ELISA	Human
	RISP Antibody (YA4041) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to RISP.

HY-P82613

	Complex III Subunit 7 Antibody (YA2358) QPC; QCR7; QP-C; UQBC; UQBP; UQPC; UQCR6; mc3DN3	WB, IHC-P, IP	Human, Rat
	Complex III Subunit 7 Antibody (YA2358) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Complex III Subunit 7.

HY-P82613A

	Complex III Subunit 7 Antibody (YA2358)(PBS only) QPC; QCR7; QP-C; UQBC; UQBP; UQPC; UQCR6; mc3DN3	WB, IHC-P, IP	Human, Rat
	Complex III Subunit 7 Antibody (YA2358) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Complex III Subunit 7.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-151738

Fmoc-Aeg(N3)-OH		Azide
Fmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis . Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Targets Recommended: Melanocortin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112251GL

D-Lin-MC3-DMA (GMP Like)	Liposome	Cancer
D-Lin-MC3-DMA (GMP Like) is the GMP Like class D-Lin-MC3-DMA (HY-112251). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

mc3

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Natural
Products