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  2. Aloin

Aloin (Synonyms: Aloin-A; Barbaloin-A)

Cat. No.: HY-N0123 Purity: 98.78%
Handling Instructions

Aloin(Aloin-A; Barbaloin-A) is a natural antitumor anthraquinone glycoside with iron chelating and non-atherogenic activities.

For research use only. We do not sell to patients.

Aloin Chemical Structure

Aloin Chemical Structure

CAS No. : 1415-73-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
50 mg USD 50 In-stock
Estimated Time of Arrival: December 31
100 mg USD 65 In-stock
Estimated Time of Arrival: December 31
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Description

Aloin(Aloin-A; Barbaloin-A) is a natural antitumor anthraquinone glycoside with iron chelating and non-atherogenic activities. IC50 value: Target: in vitro: Aloin significantly inhibited HUVECs proliferation, migration and tube formation in vitro. suppressed activation of VEGF receptor (VEGFR) 2 and STAT3 phosphorylation in endothelial cells. In addition, the constitutively activated STAT3 protein, and the expression of STAT3-regulated antiapoptotic (Bcl-xL), proliferative (c-Myc), and angiogenic (VEGF) proteins were also down-regulated in response to AL in human SW620 cancer cells [1]. aloin exerted inhibition of cell proliferation, adhesion and invasion abilities of B16-F10 melanoma cells under non-cytotoxic concentrations. Furthermore, aloin induced melanoma cell differentiation through the enhancement of melanogenesis and transglutaminase activity [2]. in vivo: Aloin substantially reduced tumor volumes and weight in vivo mouse xenografts, without obviously toxicity [1]. Aloin (10, 30 mg/kg bw) or vehicle was given by gavage to mice after each alcohol administration. Alcohol elevated the serum transaminases alanine aminotransferase, aspartate aminotransferase, total cholesterol and triglyceride levels which were significantly attenuated by the co-administration of aloin (p < 0.05) [3].

Molecular Weight

418.39

Formula

C₂₁H₂₂O₉

CAS No.

1415-73-2

SMILES

O=C1C2=C(C=CC=C2O)[[email protected]]([[email protected]]3([H])O[[email protected]](CO)[[email protected]@H](O)[[email protected]](O)[[email protected]]3O)C4=CC(CO)=CC(O)=C14

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Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 27 mg/mL (64.53 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3901 mL 11.9506 mL 23.9011 mL
5 mM 0.4780 mL 2.3901 mL 4.7802 mL
10 mM 0.2390 mL 1.1951 mL 2.3901 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Aloin
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