1. GPCR/G Protein
    Neuronal Signaling
  2. Melanocortin Receptor
  3. JKC363 TFA

JKC363 TFA 

Cat. No.: HY-P1213A
Handling Instructions

JKC363 TFA, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC363 TFA blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect.

For research use only. We do not sell to patients.

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JKC363 TFA Chemical Structure

JKC363 TFA Chemical Structure

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Description

JKC363 TFA, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC363 TFA blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect[1][2].

Molecular Weight

1620.73

Formula

C₇₁H₉₃F₃N₁₉O₁₈S₂

Sequence Shortening

{Mpa}-EH-{D-2-Nal}-RWGCPPKD (Disulfide bridge:Mpa1-Cys8)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

JKC363JKC 363JKC-363Melanocortin ReceptorMC ReceptornociceptivebehaviourTRHreleasehormoneInhibitorinhibitorinhibit

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JKC363 TFA
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HY-P1213A
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