1. GPCR/G Protein
    Neuronal Signaling
  2. Melanocortin Receptor
  3. JKC363

JKC363 

Cat. No.: HY-P1213
Handling Instructions

JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect.

For research use only. We do not sell to patients.

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JKC363 Chemical Structure

JKC363 Chemical Structure

CAS No. : 436083-30-6

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Description

JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect[1][2].

Molecular Weight

1506.71

Formula

C₆₉H₉₁N₁₉O₁₆S₂

CAS No.

436083-30-6

Sequence Shortening

{Mpa}-EH-{D-2-Nal}-RWGCPPKD (Disulfide bridge:Mpa1-Cys8)

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

JKC363JKC 363JKC-363Melanocortin ReceptorMC ReceptornociceptivebehaviourTRHreleasehormoneInhibitorinhibitorinhibit

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