2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. JKC363

JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

JKC363 Chemical Structure

JKC363 Chemical Structure

CAS No. : 436083-30-6

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5 mg USD 170 In-stock
10 mg USD 255 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect[1][2].

IC50 & Target

MC4R

 

Molecular Weight

1506.71

Formula

C69H91N19O16S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{Mpa}-Glu-His-{D-2-Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Mpa1-Cys8)
Sequence Shortening

{Mpa}-EH-{D-2-Nal}-RWGCPPKD-NH2 (Disulfide bridge:Mpa1-Cys8)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (33.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6637 mL 3.3185 mL 6.6370 mL
5 mM 0.1327 mL 0.6637 mL 1.3274 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6637 mL 3.3185 mL 6.6370 mL 16.5924 mL
5 mM 0.1327 mL 0.6637 mL 1.3274 mL 3.3185 mL
10 mM 0.0664 mL 0.3318 mL 0.6637 mL 1.6592 mL
15 mM 0.0442 mL 0.2212 mL 0.4425 mL 1.1062 mL
20 mM 0.0332 mL 0.1659 mL 0.3318 mL 0.8296 mL
25 mM 0.0265 mL 0.1327 mL 0.2655 mL 0.6637 mL
30 mM 0.0221 mL 0.1106 mL 0.2212 mL 0.5531 mL
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JKC363 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JKC363436083-30-6JKC 363JKC-363Melanocortin ReceptorMC ReceptornociceptivebehaviourTRHreleasehormoneInhibitorinhibitorinhibit

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