nor-MC3
Based on 1 Customer Validation
nor-MC3 is an MC3-type ionizable lipid with C17 unsaturated chains, formulated in lipid nanoparticles for nucleic acid (mRNA and siRNA) delivery and supports in vitro and in vivo transfection.
For research use only. We do not sell to patients.
- CAS No.: 2870681-06-2
- Formula: C41H75NO2
- Molecular Weight:614.04
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Storage:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
nor-MC3-based mRNA LNPs (0.03-10 μg/mL mRNA; 24 h) exhibit superior in vitro transfection efficiency in HuH7 cells compared to MC3-based LNPs, with enhanced activity at 10 μg/mL mRNA[1].
nor-MC3-based siRNA LNPs (0.03-1 μg/mL siRNA) exhibit comparable in vitro knockdown efficiency in stably luciferase-expressing 22Rv1 cells to MC3-based LNPs, with enhanced activity at 0.5 μg/mL siRNA and a similar EC50 value of 0.1644 μg/mL siRNA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (6-8 weeks old)[1]
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Dosage:1 mg/kg mRNA
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Administration:i.v.; single injection
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Result:Exhibited high luminescence intensity per mg liver or spleen tissue.
Chemical Information
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CAS No. 2870681-06-2
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Appearance Liquid
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Molecular Weight 614.04
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Formula C41H75NO2
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SMILES
CN(C)CCCC(OC(CCCCCCC/C=C\C/C=C\CCCCC)CCCCCCC/C=C\C/C=C\CCCCC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Protocols
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
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RNA interference technology
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing gene transcription or activating RNA degradation. This mechanism was discovered in plants in 1998 by Andrew Fire and Craig Mello. Today, this phenomenon can be observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals.
Purity & Documentation
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Data Sheet (263 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
nor-MC3 Related Classifications
HY-185010 Related Classifications
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