2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. γ-1-Melanocyte Stimulating Hormone (MSH), amide

γ-1-Melanocyte Stimulating Hormone (MSH), amide 

Cat. No.: HY-P1531 Purity: 99.32%
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γ-1-Melanocyte Stimulating Hormone (MSH), amide is a 11-amino acid peptide. γ-1-Melanocyte Stimulating Hormone (MSH) regulates sodium (Na+) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R).

For research use only. We do not sell to patients.

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γ-1-Melanocyte Stimulating Hormone (MSH), amide Chemical Structure

γ-1-Melanocyte Stimulating Hormone (MSH), amide Chemical Structure

CAS No. : 72629-65-3

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1 mg USD 90 In-stock
5 mg USD 290 In-stock
10 mg USD 490 In-stock
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Based on 1 publication(s) in Google Scholar

γ-1-Melanocyte Stimulating Hormone (MSH), amide Related Antibodies

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Description

γ-1-Melanocyte Stimulating Hormone (MSH), amide is a 11-amino acid peptide. γ-1-Melanocyte Stimulating Hormone (MSH) regulates sodium (Na+) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R).

IC50 & Target

MC3R

 

In Vitro

γ-Melanocyte Stimulating Hormone (γ-MSH) regulates a multitude of metabolic functions including energy homeostasis, food intake, sodium (Na+) balance, and blood pressure regulation. γ-MSH is processed from the precursor hormone pro-opio-melanocortin (POMC) in the pituitary gland, where component peptides are released into the cerebral spinal fluid and systemic circulation. The natural receptor for γ-MSH is the melanocortin receptor 3 (MC3-R), a G-protein-coupled receptor that activates adenylate cyclase and is expressed in brain (hypothalamus, cortex, and thalamus), gut, placenta, and kidney. γ-MSH regulates Na+ balance by inducing urinary Na+ excretion (natriuresis) under conditions of high dietary salt intake[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

γ-1-Melanocyte Stimulating Hormone (MSH), amide Related Antibodies
Molecular Weight

1512.90

Formula

C72H97N21O14S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

YVMGHFRWDRF-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (16.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6610 mL 3.3049 mL 6.6098 mL
5 mM 0.1322 mL 0.6610 mL 1.3220 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.6610 mL 3.3049 mL 6.6098 mL 16.5246 mL
5 mM 0.1322 mL 0.6610 mL 1.3220 mL 3.3049 mL
10 mM 0.0661 mL 0.3305 mL 0.6610 mL 1.6525 mL
15 mM 0.0441 mL 0.2203 mL 0.4407 mL 1.1016 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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γ-1-Melanocyte Stimulating Hormone (MSH), amide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

γ-1-Melanocyte Stimulating Hormone (MSH), amide72629-65-3Melanocortin ReceptorMC ReceptorInhibitorinhibitorinhibit

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