1. GPCR/G Protein
    Neuronal Signaling
  2. Melanocortin Receptor
  3. γ-1-Melanocyte Stimulating Hormone (MSH), amide

γ-1-Melanocyte Stimulating Hormone (MSH), amide 

Cat. No.: HY-P1531
Handling Instructions

γ-1-Melanocyte Stimulating Hormone (MSH), amide is a 11-amino acid peptide. γ-1-Melanocyte Stimulating Hormone (MSH) regulates sodium (Na+) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R).

For research use only. We do not sell to patients.

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γ-1-Melanocyte Stimulating Hormone (MSH), amide Chemical Structure

γ-1-Melanocyte Stimulating Hormone (MSH), amide Chemical Structure

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Description

γ-1-Melanocyte Stimulating Hormone (MSH), amide is a 11-amino acid peptide. γ-1-Melanocyte Stimulating Hormone (MSH) regulates sodium (Na+) balance and blood pressure through activation of the melanocortin receptor 3 (MC3-R).

IC50 & Target

Melanocortin receptor 3 (MC3-R)[1]

In Vitro

γ-Melanocyte Stimulating Hormone (γ-MSH) regulates a multitude of metabolic functions including energy homeostasis, food intake, sodium (Na+) balance, and blood pressure regulation. γ-MSH is processed from the precursor hormone pro-opio-melanocortin (POMC) in the pituitary gland, where component peptides are released into the cerebral spinal fluid and systemic circulation. The natural receptor for γ-MSH is the melanocortin receptor 3 (MC3-R), a G-protein-coupled receptor that activates adenylate cyclase and is expressed in brain (hypothalamus, cortex, and thalamus), gut, placenta, and kidney. γ-MSH regulates Na+ balance by inducing urinary Na+ excretion (natriuresis) under conditions of high dietary salt intake[1].

Molecular Weight

1512.90

Formula

C₇₂H₉₇N₂₁O₁₄S

Sequence

Tyr-Val-Met-Gly-His-Phe-Arg-Trp-Asp-Arg-Phe-NH2

Sequence Shortening

YVMGHFRWDRF-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product name:
γ-1-Melanocyte Stimulating Hormone (MSH), amide
Cat. No.:
HY-P1531
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