1. GPCR/G Protein
    Neuronal Signaling
  2. Melanocortin Receptor

β-Melanocyte Stimulating Hormone (MSH), human (Synonyms: Beta-MSH (1-22) (human))

Cat. No.: HY-P1504
Handling Instructions

β-Melanocyte Stimulating Hormone (MSH), human is a melanocortin (MC) receptor agonist.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

β-Melanocyte Stimulating Hormone (MSH), human Chemical Structure

β-Melanocyte Stimulating Hormone (MSH), human Chemical Structure

CAS No. : 17908-57-5

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

β-Melanocyte Stimulating Hormone (MSH), human is a melanocortin (MC) receptor agonist.

IC50 & Target

Melanocortin[1]

In Vitro

β-Melanocyte Stimulating Hormone is a powerful anti-inflammatory agent which effect is brought by activation of the central MC3/MC4 receptors and thereby inhibits NO production by inhibiting the translocation of transcription factor NF-κB to the nuclei of the brain cells and decreasing iNOS expression[1]. β-Melanocyte Stimulating Hormone has significantly higher at human MC4-R transfected into CHO cells (Ki=11.4±0.4 nM) and MC4-R in rat hypothalamic homogenates (Ki=22.5±2.3 nM)[2].

In Vivo

β-Melanocyte Stimulating Hormone suppresses LPS-induced nuclear translocation of the transcription factor NF-κB, and inhibits the expression of inducible nitric oxide synthase, and the following nitric oxide overproduction in the brain[1].β-Melanocyte Stimulating Hormone is a key ligand at the MC4-R populations that regulate feeding, and that inhibition of tonic release of β-MSH is one mechanism contributing to hunger in under-feeding[2].

Solvent & Solubility
In Vitro: 

10 mM in H2O

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3758 mL 1.8790 mL 3.7581 mL
5 mM 0.0752 mL 0.3758 mL 0.7516 mL
10 mM 0.0376 mL 0.1879 mL 0.3758 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Mice[1]

Male ICR mice weighing 23-25 g are housed under standard conditions (21-23°C, 12 h light-dark cycle) with unlimited access to food and water. The NO contents in the mouse forebrains are measured 6 h after drug administration using an electron paramagnetic resonance (EPR) method. β-Melanocyte Stimulating Hormone is administered intracisternaly (i.c.) with or without LPS, in a total injection volume of 10 μL (i.e., saline or 10 μL LPS with β-Melanocyte Stimulating Hormone ranging from 1 to 3 nM per animal). Control animals receive i.c. injection of 10 μL saline. The mice then receive intraperitoneal injections of spin trap reagents, i.e., 400 mg/kg DETC followed by subcutaneous injections of ferrous citrate (40 mg/kg ferrous sulphate+200 mg/kg sodium citrate, prepared directly in the syringe just before use), 0.5 h before decapitation. Thus, the spin trap reagents are administered 5.5 h after the LPS and peptide administration, when decapitation is performed 6 h after the start of the experiment. After that the forebrains are dissected and immediately frozen in liquid nitrogen.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

2660.92

Formula

C₁₁₈H₁₇₄N₃₄O₃₅S

CAS No.

17908-57-5

Sequence

Ala-Glu-Lys-Lys-Asp-Glu-Gly-Pro-Tyr-Arg-Met-Glu-His-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp

Sequence Shortening

AEKKDEGPYRMEHFRWGSPPKD

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
β-Melanocyte Stimulating Hormone (MSH), human
Cat. No.:
HY-P1504
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β-Melanocyte Stimulating Hormone (MSH), human

Cat. No.: HY-P1504