1. GPCR/G Protein
    Neuronal Signaling
  2. Melanocortin Receptor
  3. PG-931

PG-931 

Cat. No.: HY-P1208
Handling Instructions

PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R (IC50=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PG-931 Chemical Structure

PG-931 Chemical Structure

CAS No. : 667430-81-1

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Description

PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R (IC50=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo[2].

IC50 & Target

IC50: 0.58 nM (melanocortin 4 receptor)
IC50: 2.4 nM (melanocortin 5 receptor)
IC50: 55 nM (melanocortin 3 receptor)[1]

In Vivo

PG-931 (intravenous injection; 13-108 nmol/kg; single dose) produces a dose-dependent restoration of cardiovascular and respiratory functions, and improved survival in Wistar rats with haemorrhagic shock[2].

Animal Model: Wistar rats[2]
Dosage: 13-108 nmol/kg
Administration: Intravenous injection; single dose
Result: Exhibitd an anti-shock effect occurred at nanomolar doses.
Molecular Weight

1180.40

Formula

C₅₉H₈₅N₁₅O₁₁

CAS No.

667430-81-1

Sequence Shortening

Ac-{Nle}-DP-{D-Phe}-RWKPV-NH2 (Lactam bridge:Asp2-Lys7)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PG-931PG931PG 931Melanocortin ReceptorMC Receptororgan damagehaemorrhagic shockanalogrespiratory functioncardiovascularInhibitorinhibitorinhibit

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PG-931
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HY-P1208
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