2. GPCR/G Protein
    Neuronal Signaling
  3. Melanocortin Receptor
  4. PG-931

PG-931 

Cat. No.: HY-P1208 Purity: 99.86%
COA Handling Instructions

PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R (IC50=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PG-931 Chemical Structure

PG-931 Chemical Structure

CAS No. : 667430-81-1

Size Price Stock Quantity
1 mg USD 300 In-stock
Estimated Time of Arrival: December 31
5 mg USD 900 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1400 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R (IC50=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo[2].

IC50 & Target

IC50: 0.58 nM (melanocortin 4 receptor)
IC50: 2.4 nM (melanocortin 5 receptor)
IC50: 55 nM (melanocortin 3 receptor)[1]
In Vivo

PG-931 (intravenous injection; 13-108 nmol/kg; single dose) produces a dose-dependent restoration of cardiovascular and respiratory functions, and improved survival in Wistar rats with haemorrhagic shock[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats[2]
Dosage: 13-108 nmol/kg
Administration: Intravenous injection; single dose
Result: Exhibitd an anti-shock effect occurred at nanomolar doses.
Molecular Weight

1180.40

Appearance

Solid

Formula

C59H85N15O11
CAS No.
Sequence Shortening

Ac-{Nle}-DP-{D-Phe}-RWKPV-NH2 (Lactam bridge:Asp2-Lys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (84.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8472 mL 4.2359 mL 8.4717 mL
5 mM 0.1694 mL 0.8472 mL 1.6943 mL
10 mM 0.0847 mL 0.4236 mL 0.8472 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Keywords:

PG-931667430-81-1PG931PG 931Melanocortin ReceptorMC Receptororgan damagehaemorrhagic shockanalogrespiratory functioncardiovascularInhibitorinhibitorinhibit

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