1. GPCR/G Protein
    Neuronal Signaling
  2. Melanocortin Receptor
  3. PG-931 TFA

PG-931 TFA 

Cat. No.: HY-P1208A
Handling Instructions

PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R(IC50=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PG-931 TFA Chemical Structure

PG-931 TFA Chemical Structure

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Description

PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R(IC50=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo[2].

In Vivo

PG-931 (intravenous injection; 13-108 nmol/kg; single dose) produces a dose-dependent restoration of cardiovascular and respiratory functions, and improved survival in Wistar rats with haemorrhagic shock[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats[1]
Dosage: 13-108 nmol/kg
Administration: Intravenous injection; single dose
Result: Exhibits an anti-shock effect occurred at nanomolar doses.
Molecular Weight

1294.42

Formula

C₆₁H₈₆F₃N₁₅O₁₃

Sequence Shortening

Ac-{Nle}-DP-{D-Phe}-RWKPV-NH2 (Lactam bridge:Asp2-Lys7)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PG-931PG931PG 931Melanocortin ReceptorMC Receptororgan damagehaemorrhagic shockanalogrespiratory functioncardiovascularInhibitorinhibitorinhibit

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Product Name:
PG-931 TFA
Cat. No.:
HY-P1208A
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