GnRH Associated Peptide (25-53), human
GnRH Associated Peptide (GAP) (25-53), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 25-53 fragment (hGAP-25-53), can be used as immunogen to generate antiseras including MC-1, MC-2, and MC-3. GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site.
For research use only. We do not sell to patients.
- CAS No.: 106061-19-2
- Formula: C140H226N40O49S
- Molecular Weight:3285.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
GAP (10 nM; 4 h) stimulates the release of both gonadotropins in anterior pituitaries from female Sprague-Dawley rats, but inhibits the basal secretion of prolactin by ~50%, compared with inhibition levels reported for dopamin, a known prolactin-inhibiting factor[2].
GAP (0.1-10 nM; 3-4 h) inhibits prolactin secretion by 40-45%, with an IC50 value of 0.25 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 106061-19-2
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Molecular Weight 3285.60
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Formula C140H226N40O49S
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Synonyms
GAP (25-53), human
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Sequence Shortening
FECTTHQPRSPLRDLKGALESLIEEETGQ
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Culler MD, et al. Development of specific antisera and a radioimmunoassay procedure for the gonadotropin-releasing hormone associated peptide (GAP) of the LHRH prohormone. Brain Res Bull. 1986 Aug;17(2):219-23. [Content Brief]
[2]. Nikolics K, et al. A prolactin-inhibiting factor within the precursor for human gonadotropin-releasing hormone. Nature. 1985 Aug 8-14;316(6028):511-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GnRH Associated Peptide (25-53), human Related Classifications
HY-P3605 Related Classifications
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