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Results for "

tubulin assembly

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Microtubule/Tubulin (34) ADC Payload (1) Apoptosis (12) Autophagy (3) Bcr-Abl (3) Checkpoint Kinase (Chk) (1) Drug Derivative (1) Drug-Linker Conjugates for ADC (1) Ferroptosis (1) FLT3 (1) Fungal (1) HIF/HIF Prolyl-Hydroxylase (1) Isotope-Labeled Compounds (1) Kinesin (2) Mitosis (3) NF-κB (2) Parasite (3) PERK (2) Polo-like Kinase (PLK) (1) Prolyl Endopeptidase (PREP) (1) Reference Standards (5)
By Research Areas:	Cancer (31) Endocrinology (2) Infection (4) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (4)

By Targets:

Microtubule/Tubulin (34)

ADC Payload (1)

Apoptosis (12)

Autophagy (3)

Bcr-Abl (3)

Checkpoint Kinase (Chk) (1)

Drug Derivative (1)

Drug-Linker Conjugates for ADC (1)

Ferroptosis (1)

FLT3 (1)

Fungal (1)

HIF/HIF Prolyl-Hydroxylase (1)

Isotope-Labeled Compounds (1)

Kinesin (2)

Mitosis (3)

NF-κB (2)

Parasite (3)

PERK (2)

Polo-like Kinase (PLK) (1)

Prolyl Endopeptidase (PREP) (1)

Reference Standards (5)

By Research Areas:

Cancer (31)

Endocrinology (2)

Infection (4)

Inflammation/Immunology (2)

Metabolic Disease (2)

Neurological Disease (4)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Microtubule/Tubulin

Cat. No.	Nom du produit	Target	Áreas de investigación	Chemical Structure

HY-13520

Nocodazole Maximum Cited Publications 119 Publications Verification Oncodazole; R17934	Bcr-Abl Autophagy Microtubule/Tubulin Apoptosis Mitosis	Cancer
Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.

HY-115364

Parbendazole 5+ Cited Publications SKF 29044	Microtubule/Tubulin Parasite	Infection
Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC₅₀ of 530 nM, and exhibits a broad-spectrum anthelmintic activity.

HY-13649

Indibulin 1 Publications Verification ZIO 301; D 24851	Apoptosis Microtubule/Tubulin Checkpoint Kinase (Chk)	Neurological Disease Cancer
Indibulin (ZIO 301), an orally applicable inhibitor of *tubulin* assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis .

HY-N0687

Vindoline 1 Publications Verification	Microtubule/Tubulin Apoptosis NF-κB PERK	Metabolic Disease Inflammation/Immunology Endocrinology
Vindoline is an orally active vinca alkaloid. Vindoline can be extracted from the leaves of Catharanthus roseus. Vindoline has a weak inhibitory effect on the self-assembly of *tubulin. Vindoline alleviates Apoptosis, inhibits p-p65* and p-ERK. Vindoline improves diabetes, bone loss, osteoarthritis, and kidney damage .

HY-106008

Avanbulin BAL27862	Microtubule/Tubulin	Cancer
Avanbulin (BAL27862) is a potent, Colchicine site-binding, *tubulin* assembly inhibitor. Avanbulin inhibits tubulin assembly at 37 °C with an IC₅₀ of 1.4 μM. Avanbulin binds to tubulin with an apparent K_d value of 244 nM. Avanbulin can be used for the research of cancer and cell division .

HY-148870

Maytansinoid B	ADC Payload	Cancer
Maytansinoid B is a kind of ADC Cytotoxin. Maytansinoid B can be used to conjugates with antibodies to form antibody-drug conjugates (ADCs). Maytansinoids are known as antimitotic agents, binding to tubulin and inhibiting microtubule assembly. Maytansinoids induces G2/M arrest in the cell cycle to induce apoptosis .

HY-119357

TN-16	Microtubule/Tubulin Apoptosis Autophagy	Neurological Disease Cancer
TN-16 is a Microtubule polymerization inhibitor. TN-16 induces G₂/M cell cycle arrest, metaphase mitotic arrest and Apoptotic cell death in cells, and blocks late Autophagic flux by inhibiting autophagosome-lysosome fusion. TN-16 suppresses tumor growth in syngeneic mouse breast cancer models. TN-16 can be used in research related to neuroblastoma, cervical cancer, breast cancer and other tumors .

HY-128908

MC-Val-Cit-PAB-Indibulin	Drug-Linker Conjugates for ADC	Cancer
MC-Val-Cit-PAB-Indibulin is a agent-linker conjugate for ADC with potent antitumor activity by using Indibulin (an orally applicable inhibitor of tubulin assembly), linked via the ADC linker MC-Val-Cit-PAB.

HY-16191

ELR510444 1 Publications Verification	Microtubule/Tubulin Apoptosis HIF/HIF Prolyl-Hydroxylase Mitosis	Cancer
ELR510444 is an orally active *tubulin* inhibitor with an IC₅₀ of 10 μM. ELR510444 binds to the colchicine-binding site on β-tubulin, inhibits tubulin assembly, depolymerizes microtubules and blocks HIF activity. ELR510444 induces cellular microtubule loss, abnormal mitotic spindle, mitotic arrest, apoptosis, morphological changes in tumor endothelial cells, and inhibits cancer cell proliferation, angiogenesis and tumor growth. ELR510444 can be used in research related to various cancers such as renal cell carcinoma .

HY-125374

Larotaxel XRP9881	Apoptosis	Cancer
Larotaxel (XRP9881) is a taxane analogue with preclinical activity against taxane-resistant breast cancer. Larotaxel (XRP9881) exerts its cytotoxic effect by promoting tubulin assembly and stabilizing microtubules, ultimately leading to cell death by apoptosis. It presents the ability to cross the blood brain barrier and has a much lower affinity for P-glycoprotein 1 than Docetaxel .

HY-151879

Tubulin inhibitor 30	Microtubule/Tubulin Ferroptosis	Cancer
Tubulin inhibitor 30 (Compound 15) is a *tubulin* assembly inhibitor with an IC₅₀ of 0.52 μM. Tubulin inhibitor 30 can induce ferroptosis .

HY-120921

Zoxamide RH-7281	Fungal Microtubule/Tubulin	Infection
Zoxamide (RH-7281) is an oomycete Fungicide and covalent *β-tubulin* inhibitor. RH-7281 inhibits the assembly of tubulin into microtubules in vitro. Zoxamide binds covalently to β-tubulin, disrupting microtubule assembly and the cytoskeleton. Zoxamide blocks nuclear division in germinated hyphae of Phytophthora capsici and inhibits hyphal growth of Phytophthora capsici .

HY-13520R

Nocodazole (Standard) Oncodazole (Standard); R17934 (Standard)	Bcr-Abl Autophagy Microtubule/Tubulin Apoptosis Mitosis Reference Standards	Cancer
Nocodazole (Standard) is the analytical standard of Nocodazole. This product is intended for research and analytical applications. Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.

HY-120890

3,4',5-Trismethoxybenzophenone	Microtubule/Tubulin	Cancer
3,4',5-Trismethoxybenzophenone (compound 16a) is a potent *tubulin* assembly inhibitor with an IC₅₀ value of 2.6 µM .

HY-N0687R

Vindoline (Standard)	Reference Standards Microtubule/Tubulin Apoptosis NF-κB PERK	Metabolic Disease Inflammation/Immunology Endocrinology
Vindoline (Standard) is an analytical standard of Vindoline (HY-N0687). This product is intended for research and analytical applications. Vindoline is an orally active vinca alkaloid. Vindoline can be extracted from the leaves of Catharanthus roseus. Vindoline has a weak inhibitory effect on the self-assembly of *tubulin. Vindoline alleviates Apoptosis, inhibits p-p65* and p-ERK. Vindoline improves diabetes, bone loss, osteoarthritis, and kidney damage .

HY-130559

SL-3-19	Microtubule/Tubulin Apoptosis	Cancer
SL-3-19 is a *tubulin* ligand. SL-3-19 exhibits antitumor activity against esophageal squamous cell carcinoma (ESCC) both in vitro and in vivo by inhibiting microtubule assembly, inducing G2/M phase cell cycle arrest and apoptosis, and disrupting tumor blood vessels. SL-3-19 has a higher activity than SL-1-73 (HY-130558). SL-3-19 can be used for the research of ESCC and other tumors .

HY-147888

Tubulin inhibitor 29	Microtubule/Tubulin	Cancer
Tubulin inhibitor 29 (compound 3c) is a potent *tubulin* inhibitor with an IC₅₀ value of 1.2 µM. Tubulin inhibitor 29 shows antiproliferative effects with an IC₅₀ value of 7.5 µM for MCF-7 cells. Tubulin inhibitor 29 inhibits tubulin assembly and bounds in the colchicine site .

HY-163270

PM534	Microtubule/Tubulin	Cancer
PM534, *tubulin* targeting agent, inhibits tubulin assembly with IC₅₀ values of 0.8-3.2 nM. PM534 binds to the colchicine site of tubulin, which has high antitumor activity .

HY-161747

Tubulin inhibitor 46	Microtubule/Tubulin	Cancer
Tubulin inhibitor 46 (Compound 21) is a potent **tubulin assembly** inhibitor. Tubulin inhibitor 46 has antiproliferative activities, with GI₅₀ values of 0.0095-33 μM for cancer and non-cancerous cells. Tubulin inhibitor 46 can be used for the reserch of cancer .

HY-101989

Tubulin polymerization-IN-24	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-24 (compound HMBA) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-24 inhibits MCF-7 cells proliferation. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-24 increase the GTP hydrolysis rate and inhibits microtubule assembly .

HY-115364S

Parbendazole-d3 SKF 2904-d₃	Isotope-Labeled Compounds Microtubule/Tubulin Parasite	Infection
Parbendazole-d₃ is the deuterium labeled Parbendazole. Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity.

HY-115364R

Parbendazole (Standard) SKF 29044 (Standard)	Reference Standards Microtubule/Tubulin Parasite	Infection
Parbendazole (Standard) is the analytical standard of Parbendazole. This product is intended for research and analytical applications. Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC₅₀ of 530 nM, and exhibits a broad-spectrum anthelmintic activity.

HY-133207

Myoseverin B	Microtubule/Tubulin	Cancer
Myoseverin B is a microtubule assembly inhibitor capable of inhibiting the polymerization of *tubulin* (IC₅₀ = 2 μM) and exhibiting low cytotoxicity in most cell types. Myoseverin B can be used in research as an antitumor agent .

HY-13649R

Indibulin (Standard) ZIO 301 (Standard); D 24851 (Standard)	Microtubule/Tubulin Apoptosis Reference Standards	Neurological Disease Cancer
Indibulin (Standard) is the analytical standard of Indibulin. This product is intended for research and analytical applications. Indibulin (ZIO 301), an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis .

HY-162518

Eg5-IN-3	Kinesin Microtubule/Tubulin	Cancer
Eg5-IN-3 (5) is an Eg5 inhibitor that targets the novel allosteric pocket (α4/α6/L11). Eg5-IN-3 (5) causes tubulin assembly distortion with irregular morphology, resulting in a typical mitotic arrest similar to Monastrol (HY-101071A) .

HY-145827

KIF18A-IN-4	Kinesin Microtubule/Tubulin	Cancer
KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC₅₀=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity .

HY-155112

Antiproliferative agent-30	Microtubule/Tubulin FLT3 Bcr-Abl	Cancer
Antiproliferative agent-30 (Compound 8g) inhibits *tubulin* assembly and inhibits FLT3 and Abl1. Antiproliferative agent-30 has vascular-disrupting activity. Antiproliferative agent-30 has broad antiproliferative activities against cancer cell lines (IC₅₀s: 0.054 nM, 0.008 nM, 0.144 nM for HCT-116, K562, MV-4-11 cells respectively). Antiproliferative agent-30 also has anticancer effect against AML with FLT3-ITD-TKD mutation .

HY-106008R

Avanbulin (Standard) BAL27862 (Standard)	Reference Standards Microtubule/Tubulin	Cancer
Avanbulin (Standard) is the analytical standard of Avanbulin (HY-106008). This product is intended for research and analytical applications. Avanbulin (BAL27862) is a potent, Colchicine site-binding, tubulin assembly inhibitor. Avanbulin inhibits tubulin assembly at 37 °C with an IC₅₀ of 1.4 μM. Avanbulin binds to tubulin with an apparent K_d value of 244 nM. Avanbulin can be used for the research of cancer and cell division .

HY-106021

Tasidotin ILX651 free base	Microtubule/Tubulin Prolyl Endopeptidase (PREP)	Cancer
Tasidotin (ILX651 free base) is a *tubulin* inhibitor and competitive Prolyl Endopeptidase (PREP) inhibitor, with an IC₅₀ of 10 μM against bovine tubulin. Tasidotin exhibits high cerebrospinal fluid penetration in non-human primates. Tasidotin antagonizes microtubule assembly and induces an extended assembly lag phase, thereby inhibiting mitosis and cell proliferation, and exerts cytotoxic and oncolytic effects on cancer cells. Tasidotin is metabolized into polypeptides and proline inside cells, and its in vivo metabolism is mediated by prolyl endopeptidase. Tasidotin can be applied in research related to Burkitt's lymphoma, breast cancer, leukemia, melanoma, central nervous system malignancies and various solid tumors .

HY-170864

BKS3031A	Microtubule/Tubulin	Neurological Disease Cancer
BKS3031A is the inhibitor for *αβ-tubulin* that binds to the colchicine binding site, and inhibits the microtubule assembly dynamics .

HY-W072781

N-Deacetylthiocolchicine	Microtubule/Tubulin	Cancer
N-Deacetylthiocolchicine is a *tubulin* inhibitor with an IC₅₀ value of 2.2 nM in MDR-negative MDA-MB 231 breast cancer cells. N-Deacetylthiocolchicine exerts antiproliferative activity by binding to tubulin to interfere with microtubule assembly, arresting cells in mitosis during the cell cycle. N-Deacetylthiocolchicine is promising for research of malignancies such as breast cancer .

HY-117759

Deacetoxyvinzolidine KAR-2	Microtubule/Tubulin	Cancer
Deacetoxyvinzolidine (KAR-2) is a bis-indol derivative with high anti-microtubular and anti-tumour activities. Deacetoxyvinzolidine exhibits high affinity for bovine purified brain tubulin (K_d of 3 μM) and inhibits microtubule assembly at a concentration of 10 nM. Deacetoxyvinzolidine does not possess anti-calmodulin activity. Deacetoxyvinzolidine can be used for the study of leukaemia .

HY-182478

MDL-27048	Microtubule/Tubulin	Cancer
MDL-27048, a *tubulin* inhibitor, binds competitively, reversibly to the Colchicine (HY-16569)-binding site on tubulin heterodimers. MDL-27048 inhibits microtubule assembly, induces slow depolymerization of preassembled microtubules, disrupts microtubule polymerization-depolymerization dynamics, and disrupts cytoplasmic microtubule networks. MDL-27048 exerts growth inhibitory effects on human cancer cells, induces mitotic arrest, and does not disrupt actin filaments at microtubule-depolymerizing concentrations. MDL-27048 can be used for the research of malignant tumors .

HY-185269

2'-Deoxy-PTX	Microtubule/Tubulin Drug Derivative	Cancer
2'-Deoxy-PTX is a Paclitaxel (HY-B0015) derivative and microtubule assembly inducer. 2'-Deoxy-PTX binds to GMPcPP-stabilized microtubules, with a Ka_app of 0.50 × 10 ⁶ M ^-1. 2′-Deoxy-PTX induces *Tubulin* to assemble into normal microtubules. 2'-Deoxy-PTX can be used for the research of prostate cancer .

HY-130558

SL-1-73	Apoptosis Microtubule/Tubulin	Cancer
SL-1-73 is a *tubulin* ligand. SL-1-73 exhibits antitumor activity against esophageal squamous cell carcinoma (ESCC) both in vitro and in vivo by inhibiting microtubule assembly, inducing G2/M phase cell cycle arrest and apoptosis, and disrupting tumor blood vessels. SL-1-73 can be used for the research of ESCC and other tumors .

HY-N13795

3,4,3'-Tri-O-methylflavellagic acid	Polo-like Kinase (PLK) Microtubule/Tubulin	Cancer
3,4,3'-Tri-O-methylflavellagic acid is a flavonoid inhibitor that targets *αβ-tubulin* (colchicine binding site) and polo-like kinase-1 (PLK-1), and can be isolated from the roots of Anogeissus leiocarpus. 3,4,3'-Tri-O-methylflavellagic acid interferes with microtubule assembly dynamics and kinase activity, exhibiting anti-cancer cell proliferation and potent anti-nociceptive effects .

HY-Z9022

Iso cephalomannine	Microtubule/Tubulin	Cancer
Iso cephalomannine is a tubulin-targeting cytotoxic agent. Iso cephalomannine induces cytotoxicity in breast cancer cells. Iso cephalomannine can be used in breast cancer-related research .

Cat. No.	Nom du produit	Category	Target	Chemical Structure