2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. SL-3-19

SL-3-19 is a tubulin ligand. SL-3-19 exhibits antitumor activity against esophageal squamous cell carcinoma (ESCC) both in vitro and in vivo by inhibiting microtubule assembly, inducing G2/M phase cell cycle arrest and apoptosis, and disrupting tumor blood vessels. SL-3-19 has a higher activity than SL-1-73 (HY-130558). SL-3-19 can be used for the research of ESCC and other tumors.

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SL-3-19

SL-3-19 Chemical Structure

CAS No. : 2000199-45-9

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SL-3-19 Related Antibodies

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Description

SL-3-19 is a tubulin ligand. SL-3-19 exhibits antitumor activity against esophageal squamous cell carcinoma (ESCC) both in vitro and in vivo by inhibiting microtubule assembly, inducing G2/M phase cell cycle arrest and apoptosis, and disrupting tumor blood vessels. SL-3-19 has a higher activity than SL-1-73 (HY-130558). SL-3-19 can be used for the research of ESCC and other tumors[1].

Cellular Effect
Cell Line Type Value Description References
Bel-7402 IC50
0.056 μM
Compound: 13f
Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay
[PMID: 27919655]
Bel-7402 IC50
0.056 μM
Compound: 4b
Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay
Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay
[PMID: 32113125]
HepG2 IC50
0.012 μM
Compound: 13f
Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
[PMID: 27919655]
HepG2 IC50
0.012 μM
Compound: 4b
Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay
Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay
[PMID: 32113125]
MCF7 IC50
0.014 μM
Compound: 13f
Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay
[PMID: 27919655]
MCF7 IC50
0.014 μM
Compound: 4b
Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay
[PMID: 32113125]
MIA PaCa-2 IC50
0.051 μM
Compound: 13f
Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
[PMID: 27919655]
Molecular Weight

413.45

Formula

C20H19N3O5S
CAS No.
SMILES

O=S(NC1=CC=C(OC)N=C1OC)(C2=CC=C3C(C4=C(N3C)C=C(O)C=C4)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SL-3-19 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SL-3-192000199-45-9Microtubule/TubulinApoptosisKYSE 30KYSE 170KYSE 140KYSE 410KYSE 510HepG2ECV304ESCC xenografts modelInhibitorinhibitorinhibit

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