SL-3-19
SL-3-19 is a tubulin ligand. SL-3-19 exhibits antitumor activity against esophageal squamous cell carcinoma (ESCC) both in vitro and in vivo by inhibiting microtubule assembly, inducing G2/M phase cell cycle arrest and apoptosis, and disrupting tumor blood vessels. SL-3-19 has a higher activity than SL-1-73 (HY-130558). SL-3-19 can be used for the research of ESCC and other tumors.
For research use only. We do not sell to patients.
- CAS No.: 2000199-45-9
- Formula: C20H19N3O5S
- Molecular Weight:413.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Bel-7402 | IC50 |
0.056 μM
Compound: 13f
|
Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay
|
[PMID: 27919655] |
| Bel-7402 | IC50 |
0.056 μM
Compound: 4b
|
Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay
Antiproliferative activity against human Bel-7402 cells measured after 48 hrs by SRB assay
|
[PMID: 32113125] |
| HepG2 | IC50 |
0.012 μM
Compound: 13f
|
Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
|
[PMID: 27919655] |
| HepG2 | IC50 |
0.012 μM
Compound: 4b
|
Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay
Antiproliferative activity against human HepG2 cells measured after 48 hrs by SRB assay
|
[PMID: 32113125] |
| MCF7 | IC50 |
0.014 μM
Compound: 13f
|
Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay
|
[PMID: 27919655] |
| MCF7 | IC50 |
0.014 μM
Compound: 4b
|
Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 cells measured after 48 hrs by SRB assay
|
[PMID: 32113125] |
| MIA PaCa-2 | IC50 |
0.051 μM
Compound: 13f
|
Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
|
[PMID: 27919655] |
Chemical Information
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CAS No. 2000199-45-9
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Molecular Weight 413.45
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Formula C20H19N3O5S
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SMILES
O=S(NC1=CC=C(OC)N=C1OC)(C2=CC=C3C(C4=C(N3C)C=C(O)C=C4)=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)