SL-1-73
SL-1-73 is a tubulin ligand. SL-1-73 exhibits antitumor activity against esophageal squamous cell carcinoma (ESCC) both in vitro and in vivo by inhibiting microtubule assembly, inducing G2/M phase cell cycle arrest and apoptosis, and disrupting tumor blood vessels. SL-1-73 can be used for the research of ESCC and other tumors.
For research use only. We do not sell to patients.
- CAS No.: 2000199-44-8
- Formula: C20H19N3O5S
- Molecular Weight:413.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Bel-7402 | IC50 |
1.83 μM
Compound: 13k
|
Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human Bel7402 assessed as reduction in cell viability measured after 48 hrs by SRB assay
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[PMID: 27919655] |
| HepG2 | IC50 |
0.096 μM
Compound: 13k
|
Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human HepG2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
|
[PMID: 27919655] |
| KYSE-140 | IC50 |
0.01 μM
Compound: 12c
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Antiproliferative activity against human KYSE-140 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human KYSE-140 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay
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[PMID: 34838335] |
| KYSE-30 | IC50 |
0.01 μM
Compound: 12c
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Antiproliferative activity against human KYSE-30 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human KYSE-30 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay
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[PMID: 34838335] |
| KYSE-410 | IC50 |
0.01 μM
Compound: 12c
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Antiproliferative activity against human KYSE-410 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human KYSE-410 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay
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[PMID: 34838335] |
| KYSE-510 | IC50 |
0.01 μM
Compound: 12c
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Antiproliferative activity against human KYSE-510 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay
Antiproliferative activity against human KYSE-510 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay
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[PMID: 34838335] |
| MCF7 | IC50 |
0.45 μM
Compound: 13k
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Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 48 hrs by SRB assay
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[PMID: 27919655] |
| MIA PaCa-2 | IC50 |
0.43 μM
Compound: 13k
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Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
Antiproliferative activity against human MIAPaCa2 assessed as reduction in cell viability measured after 48 hrs by SRB assay
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[PMID: 27919655] |
Chemical Information
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CAS No. 2000199-44-8
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Molecular Weight 413.45
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Formula C20H19N3O5S
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SMILES
O=S(NC1=CC=C(OC)N=C1OC)(C2=CC(C3=CC(O)=CC=C3N4C)=C4C=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SL-1-73 Related Classifications
HY-130558 Related Classifications
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