2000199-45-9
Chemical Structure
SL-3-19
- CAS No.: 2000199-45-9
- Formula:C20H19N3O5S
- Molecular Weight:413.45
IUPAC Name: N-(2,6-dimethoxypyridin-3-yl)-7-hydroxy-9-methyl-9H-carbazole-3-sulfonamide
InChIKey: JHMJOKFFTGCOOT-UHFFFAOYSA-N
SMILES: O=S(NC1=CC=C(OC)N=C1OC)(C2=CC=C3C(C4=C(N3C)C=C(O)C=C4)=C2)=O
Biological Activity: SL-3-19 is a tubulin ligand. SL-3-19 exhibits antitumor activity against esophageal squamous cell carcinoma (ESCC) both in vitro and in vivo by inhibiting microtubule assembly, inducing G2/M phase cell cycle arrest and apoptosis, and disrupting tumor blood vessels. SL-3-19 has a higher activity than SL-1-73 (HY-130558). SL-3-19 can be used for the research of ESCC and other tumors[1].
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SL-3-19 | SL-3-19 is a tubulin ligand. SL-3-19 exhibits antitumor activity against esophageal squamous cell carcinoma (ESCC) both in vitro and in vivo by inhibiting microtubule assembly, inducing G2/M phase cell cycle arrest and apoptosis, and disrupting tumor blood vessels. SL-3-19 has a higher activity than SL-1-73 (HY-130558). SL-3-19 can be used for the research of ESCC and other tumors. | |||||||||||||||||||||
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Keywords
