2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Ferroptosis
  4. Tubulin inhibitor 30

Tubulin inhibitor 30 (Compound 15) is a tubulin assembly inhibitor with an IC50 of 0.52 μM. Tubulin inhibitor 30 can induce ferroptosis.

For research use only. We do not sell to patients.

Tubulin inhibitor 30 Chemical Structure

Tubulin inhibitor 30 Chemical Structure

CAS No. : 2873383-67-4

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Tubulin inhibitor 30 Related Antibodies

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Description

Tubulin inhibitor 30 (Compound 15) is a tubulin assembly inhibitor with an IC50 of 0.52 μM. Tubulin inhibitor 30 can induce ferroptosis[1].

IC50 & Target

IC50: 0.52 μM (Tubulin)[1]
In Vitro

Tubulin inhibitor 30 (Compound 15) (0-100 nM; 48 h) inhibits the viability of MCF-7, U-87 MG and OVCAR-3 cells[1].
Tubulin inhibitor 30 is metabolically stable when incubated with human liver microsomes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin inhibitor 30 Related Antibodies

Cell Viability Assay[1]

Cell Line: MCF-7, U-87 MG and OVCAR-3 cells
Concentration: 0-100 nM
Incubation Time: 48 h
Result: Inhibited the cell viability with IC50s of 4.0, 10.06 and 2.852 nM against MCF-7, U-87 MG and OVCAR-3 cells, respectively.

Western Blot Analysis[1]

Cell Line: U-87 MG and OVCAR-3 cells
Concentration: 0-100 nM
Incubation Time: 48 h
Result: Induced a significant increase of cleaved PARP.
In Vivo

Tubulin inhibitor 30 (Compound 15) (25mg/kg; i.p.; every 2 days) inhibits the in vivo tumorigenicity of the human GBM cell line U-87 MG and the human OC cell line SKOV-3, and causes oxidative stress injury and Fe2+ accumulation in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/Cnu/nu mice, U-87 MG or SKOV-3 model[1]
Dosage: 25 mg/kg
Administration: Intraperitoneal injection, every 2 days
Result: Inhibited tumorigenicity and tumor volume. Caused oxidative stress injury and Fe2+ accumulation.
Molecular Weight

405.40

Formula

C22H19N3O5
CAS No.
SMILES

COC1=CC(C(C2=CN(C=C2C3=CC=CO3)C4=NC=CC=N4)=O)=CC(OC)=C1OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin inhibitor 30 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin inhibitor 302873383-67-4Tubulin inhibitor30Tubulin inhibitor-30Microtubule/TubulinFerroptosisMCF-7U-87 MGOVCAR-3metabolically stableInhibitorinhibitorinhibit

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