1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
  3. KIF18A-IN-4

KIF18A-IN-4 

Cat. No.: HY-145827
Handling Instructions

KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC50=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity.

For research use only. We do not sell to patients.

KIF18A-IN-4 Chemical Structure

KIF18A-IN-4 Chemical Structure

CAS No. : 1197522-21-6

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Description

KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC50=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity[1].

IC50 & Target

IC50: 6.16 μM (KIF18A)[1]

In Vitro

KIF18A-IN-4 (15 μM; 24 hours) induces a phenotype characterized by multipolar spindle arrays emanating from multiple pericentriolar material (PCM) centers in mitotic MDA-MB-157 cells (pH3+)[1].
KIF18A-IN-4 (0-10 μM; overnight) has an EC50 of 6.35 μM in OVCAR-3 cells by the mitotic index assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

413.53

Formula

C22H27N3O3S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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KIF18A-IN-4
Cat. No.:
HY-145827
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