KIF18A-IN-4
KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC50=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity.
For research use only. We do not sell to patients.
- CAS No.: 1197522-21-6
- Formula: C22H27N3O3S
- Molecular Weight:413.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
IC50: 6.16 μM (KIF18A)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-157 | IC50 |
4.8 μM
Compound: 3
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Induction of mitotic arrest in TP53 mutant human MDA-MB-157 cells assessed as multipolar spindle arrays by measuring pericentriolar material incubated for 24 hrs by mitotic index assay
Induction of mitotic arrest in TP53 mutant human MDA-MB-157 cells assessed as multipolar spindle arrays by measuring pericentriolar material incubated for 24 hrs by mitotic index assay
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[PMID: 35286090] |
| OVCAR-3 | EC50 |
5.03 μM
Compound: 3
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Antiproliferative activity against human OVCAR-3 cells by nuclear count assay
Antiproliferative activity against human OVCAR-3 cells by nuclear count assay
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[PMID: 35286090] |
| OVCAR-3 | EC50 |
6.35 μM
Compound: 3
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Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay
Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay
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[PMID: 35286090] |
KIF18A-IN-4 (15 μM; 24 hours) induces a phenotype characterized by multipolar spindle arrays emanating from multiple pericentriolar material (PCM) centers in mitotic MDA-MB-157 cells (pH3+)[1].
KIF18A-IN-4 (0-10 μM; overnight) has an EC50 of 6.35 μM in OVCAR-3 cells by the mitotic index assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1197522-21-6
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Molecular Weight 413.53
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Formula C22H27N3O3S
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SMILES
O=S(C1=CC=CC(NC(C2=C(N3CCCCC3)N=CC=C2)=O)=C1)(C4CCCC4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KIF18A-IN-4 Related Classifications
HY-145827 Related Classifications
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