2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Tubulin polymerization-IN-24

Tubulin polymerization-IN-24 (compound HMBA) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-24 inhibits MCF-7 cells proliferation. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-24 increase the GTP hydrolysis rate and inhibits microtubule assembly.

For research use only. We do not sell to patients.

Tubulin polymerization-IN-24

Tubulin polymerization-IN-24 Chemical Structure

CAS No. : 564468-51-5

Size Price Stock Quantity
10 mg Get quote 3 - 4 Weeks 4 - 5 weeks 5 - 6 weeks 2 - 3 weeks
50 mg   Get quote  
100 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Tubulin polymerization-IN-24 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tubulin polymerization-IN-24 (compound HMBA) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-24 inhibits MCF-7 cells proliferation. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-24 increase the GTP hydrolysis rate and inhibits microtubule assembly[1].

Cellular Effect
Cell Line Type Value Description References
K562 EC50
0.206 μM
Compound: 9h
Effective concentration required to arrest propidium iodide stained K562 cells in G2/M phase
Effective concentration required to arrest propidium iodide stained K562 cells in G2/M phase
[PMID: 12852768]
K562 IC50
0.02 μM
Compound: 8
Antiproliferative activity against human K562 cells after 48 hrs by hemocytometer
Antiproliferative activity against human K562 cells after 48 hrs by hemocytometer
[PMID: 21705223]
K562 IC50
0.02 μM
Compound: 9h
In vitro inhibitory concentration against human chronic myelogenous leukemia K562 cell growth
In vitro inhibitory concentration against human chronic myelogenous leukemia K562 cell growth
[PMID: 12852768]
KB EC50
0.2 μM
Compound: 10
Cell cycle arrest in KB/HeLa cells assessed as accumulation at G2/M phase after 24 hrs by flow cytometric analysis
Cell cycle arrest in KB/HeLa cells assessed as accumulation at G2/M phase after 24 hrs by flow cytometric analysis
[PMID: 17973361]
KB IC50
0.09 μM
Compound: 9h
Cytotoxic activity against cellular metabolic activity of Cervix KB/HeLa tumor cell line using XTT proliferation assay after incubation with the compound for 48 h
Cytotoxic activity against cellular metabolic activity of Cervix KB/HeLa tumor cell line using XTT proliferation assay after incubation with the compound for 48 h
[PMID: 12852768]
L1210 IC50
0.13 μM
Compound: 9h
Antiproliferative activity against L1210 phenotype L1210 VCR tumor cell line
Antiproliferative activity against L1210 phenotype L1210 VCR tumor cell line
[PMID: 12852768]
L1210 IC50
0.14 μM
Compound: 9h
Antiproliferative activity against L1210 tumor cell line
Antiproliferative activity against L1210 tumor cell line
[PMID: 12852768]
LXFL 529 IC50
0.52 μM
Compound: 9h
Tested for induction of cellular death in Human lung LXF 529L tumor cell line in Propidium Iodide Monolayer Assay
Tested for induction of cellular death in Human lung LXF 529L tumor cell line in Propidium Iodide Monolayer Assay
[PMID: 12852768]
MCF7 IC50
< 0.01 μM
Compound: 9h
Tested for induction of cellular death in Human breast MCF-7 tumor cell line in Propidium Iodide Monolayer Assay
Tested for induction of cellular death in Human breast MCF-7 tumor cell line in Propidium Iodide Monolayer Assay
[PMID: 12852768]
NCI-H460 IC50
0.07 μM
Compound: 9h
Cytotoxic activity against cellular metabolic activity of Lung NCI-H460 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h
Cytotoxic activity against cellular metabolic activity of Lung NCI-H460 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h
[PMID: 12852768]
NCI-H460 IC50
< 0.01 μM
Compound: 9h
Tested for induction of cellular death in Human lung H-460 tumor cell line in Propidium Iodide Monolayer Assay
Tested for induction of cellular death in Human lung H-460 tumor cell line in Propidium Iodide Monolayer Assay
[PMID: 12852768]
P388/ADR IC50
0.16 μM
Compound: 9h
Antiproliferative activity against P388 tumor cell line
Antiproliferative activity against P388 tumor cell line
[PMID: 12852768]
P388/ADR IC50
0.26 μM
Compound: 9h
Antiproliferative activity against P388 phenotype P388 ADR tumor cell line
Antiproliferative activity against P388 phenotype P388 ADR tumor cell line
[PMID: 12852768]
RKO IC50
0.06 μM
Compound: 9h
Cytotoxic activity against human colon adenocarcinoma RKO cells without ectopic inducible expression of cyclin-dependent kinase inhibitor p27kip1
Cytotoxic activity against human colon adenocarcinoma RKO cells without ectopic inducible expression of cyclin-dependent kinase inhibitor p27kip1
[PMID: 12852768]
RKO IC50
> 9 μM
Compound: 9h
Cytotoxic activity against human colon adenocarcinoma RKO cells with ectopic inducible expression of cyclin-dependent kinase inhibitor p27kip1
Cytotoxic activity against human colon adenocarcinoma RKO cells with ectopic inducible expression of cyclin-dependent kinase inhibitor p27kip1
[PMID: 12852768]
RXF 944 IC50
< 0.01 μM
Compound: 9h
Tested for induction of cellular death in Human renal RXF 944L tumor cell line in Propidium Iodide Monolayer Assay
Tested for induction of cellular death in Human renal RXF 944L tumor cell line in Propidium Iodide Monolayer Assay
[PMID: 12852768]
SF-268 IC50
0.03 μM
Compound: 9h
Tested for induction of cellular death in Human ZNS SF-268 tumor cell line in Propidium Iodide Monolayer Assay
Tested for induction of cellular death in Human ZNS SF-268 tumor cell line in Propidium Iodide Monolayer Assay
[PMID: 12852768]
SF-268 IC50
0.05 μM
Compound: 9h
Cytotoxic activity against cellular metabolic activity of Glioma SF-268 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h
Cytotoxic activity against cellular metabolic activity of Glioma SF-268 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h
[PMID: 12852768]
SK-OV-3 IC50
0.05 μM
Compound: 9h
Cytotoxic activity against cellular metabolic activity of Ovary SKOV3 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h
Cytotoxic activity against cellular metabolic activity of Ovary SKOV3 tumor cell line using XTT proliferation assay after incubation with the compound for 48 h
[PMID: 12852768]
In Vitro

Tubulin polymerization-IN-24 (compound HMBA) inhibits the assembly of purified tubulin (MAPs-free) in a concentration dependent manner[1].
Tubulin polymerization-IN-24 (0-100 nM) inhibits MCF-7 proliferation in a concentration dependent fashion with an IC50 value of 47 nM[1].
Tubulin polymerization-IN-24 competitively inhibits colchicine binding to tubulin with a Ki value of 3.6 μM[1].
Tubulin polymerization-IN-24 inhibits the progression of MCF-7 cells in mitosis and induces apoptotic cell death involving p53 pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-24 Related Antibodies
Molecular Weight

328.36

Formula

C22H16O3
CAS No.
SMILES

O=C1C2=C(C=CC=C2)/C(C3=CC=CC=C13)=C\C4=CC=C(OC)C(O)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Tubulin polymerization-IN-24 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-24564468-51-5Microtubule/TubulinApoptosisanticanceranti-proliferationMCF-7 cellsG2/M phaseapoptosisGTP hydrolysismicrotubule assemblyp53Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Tubulin polymerization-IN-24
Cat. No.:
HY-101989
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.