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Cat. No.: HY-163270

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PM534

PM534, tubulin targeting agent, inhibits tubulin assembly with IC₅₀ values of 0.8-3.2 nM. PM534 binds to the colchicine site of tubulin, which has high antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 2446376-25-4
Formula: C₂₀H₂₇N₃O₅S
Molecular Weight:421.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

PM534 Chemical Structure

CAS No.: 2446376-25-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

PM534, tubulin targeting agent, inhibits tubulin assembly with IC₅₀ values of 0.8-3.2 nM. PM534 binds to the colchicine site of tubulin, which has high antitumor activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	1.4 nM Compound: PM534	Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38294341]
A549	IC₅₀	1.5 nM Compound: PM534	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38294341]
HeLa	IC₅₀	1.3 nM Compound: PM534	Antiproliferative activity against human HeLa cells expressing tubulin betaIII assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells expressing tubulin betaIII assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38294341]
HeLa	IC₅₀	1.6 nM Compound: PM534	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 38294341]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 2446376-25-4
Molecular Weight 421.51
Formula C₂₀H₂₇N₃O₅S
SMILES

O=C([C@]1(N=C(SC1)/C(C)=N/O)C)N[C@@H](C2=CC(OCC3CC3)=CC(O2)=O)CCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lucena-Agell D, et al. PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin. J Med Chem. 2024 Jan 31. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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