2446376-25-4
Chemical Structure
PM534
- CAS No.: 2446376-25-4
- Formula:C20H27N3O5S
- Molecular Weight:421.51
InChIKey: FEAXXOSOWZCDTJ-NVUXMUDASA-N
SMILES: O=C([C@]1(N=C(SC1)/C(C)=N/O)C)N[C@@H](C2=CC(OCC3CC3)=CC(O2)=O)CCC
Biological Activity: PM534 is a potent tubulin inhibitor (KD = 20 nM). PM534 targets and binds to the entire colchicine-binding domain (CBD) of tubulin, thereby inhibiting tubulin assembly; this leads to cell cycle arrest at the G2-M phase and induces multinucleation and apoptosis. PM534 exhibits microtubule-destabilizing agent (MDA) activity, potent broad-spectrum antitumor activity, and anti-angiogenic effects. PM534 can be used in research concerning human non-small cell lung cancer (NSCLC), breast cancer, ovarian cancer, and prostate cancer[1][2].
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PM534 | PM534 is a potent tubulin inhibitor (KD = 20 nM). PM534 targets and binds to the entire colchicine-binding domain (CBD) of tubulin, thereby inhibiting tubulin assembly; this leads to cell cycle arrest at the G2-M phase and induces multinucleation and apoptosis. PM534 exhibits microtubule-destabilizing agent (MDA) activity, potent broad-spectrum antitumor activity, and anti-angiogenic effects. PM534 can be used in research concerning human non-small cell lung cancer (NSCLC), breast cancer, ovarian cancer, and prostate cancer. | |||||||||||||||||||||
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- [1]. Lucena-Agell D,et al. PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin. J Med Chem. 2024 Feb 22;67(4):2619-2630. [Content Brief]
- [2]. Aviles P, et al. PM534, a Novel Colchicine Site Tubulin Inhibitor with Broad-Spectrum and Resistance-Overcoming Antitumor Activity. Mol Cancer Ther. 2026 Jun 1;25(6):935-947. [Content Brief]
Keywords
