2'-Deoxy-PTX 

2'-Deoxy-PTX is a Paclitaxel (HY-B0015) derivative and microtubule assembly inducer. 2'-Deoxy-PTX binds to GMPcPP-stabilized microtubules, with a Ka_app of 0.50 × 10⁶ M^-1. 2′-Deoxy-PTX induces Tubulin to assemble into normal microtubules. 2'-Deoxy-PTX can be used for the research of prostate cancer^[1].

2'-Deoxy-PTX (15 μM; up to 25 min) induces the assembly of purified tubulin into normal microtubules at 37 °C^[1].
2'-Deoxy-PTX binds to GMPcPP-stabilized microtubules at 37 °C, with an apparent binding constant of 0.50 × 10⁶ M^-1[1].
2'-Deoxy-PTX exhibits an IC₅₀ of 526 nM against PC3 cells, with significantly reduced cytotoxicity compared with PTX^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

837.91

C₄₇H₅₁NO₁₃

156413-68-2

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sharma S, et al. Dissecting paclitaxel-microtubule association: quantitative assessment of the 2'-OH group. Biochemistry. 2013;52(13):2328-2336.  [Content Brief]