Deacetoxyvinzolidine
Deacetoxyvinzolidine (KAR-2) is a bis-indol derivative with high anti-microtubular and anti-tumour activities. Deacetoxyvinzolidine exhibits high affinity for bovine purified brain tubulin (Kd of 3 μM) and inhibits microtubule assembly at a concentration of 10 nM. Deacetoxyvinzolidine does not possess anti-calmodulin activity. Deacetoxyvinzolidine can be used for the study of leukaemia.
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- CAS No.: 165659-77-8
- Formule: C46H56ClN5O7
- Masse moléculaire:826.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Chemical Information
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CAS No. 165659-77-8
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Masse moléculaire 826.42
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Formule C46H56ClN5O7
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SMILES
CN1[C@]2([H])[C@]3(C4=CC([C@@]5(C6=C(CC[N@@]7C[C@](C[C@](O)(C7)CC)([H])C5)C8=CC=CC=C8N6)C(OC)=O)=C(OC)C=C41)[C@]9([H])[C@](C[C@]2%10C(N(C(O%10)=O)CCCl)=O)(C=CCN9CC3)CC
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Synonyms
KAR-2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Orosz F, et al. The interaction of a new anti-tumour drug, KAR-2 with calmodulin. Br J Pharmacol. 1997 Jul;121(5):955-62. [Content Brief]
[2]. Orosz F, et al. Interaction of a new bis-indol derivative, KAR-2 with tubulin and its antimitotic activity. Br J Pharmacol. 1997 Jul;121(5):947-54. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Deacetoxyvinzolidine Related Classifications
HY-117759 Related Classifications
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