Tubulin inhibitor 46

Cat. No.: HY-161747: Data Sheet Handling Instructions
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Tubulin inhibitor 46 (Compound 21) is a potent tubulin assembly inhibitor. Tubulin inhibitor 46 has antiproliferative activities, with GI₅₀ values of 0.0095-33 μM for cancer and non-cancerous cells. Tubulin inhibitor 46 can be used for the reserch of cancer.

For research use only. We do not sell to patients.

Tubulin inhibitor 46 Chemical Structure

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2058	GI₅₀	0.01 μM Compound: 21	Antiproliferative activity against human A2058 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human A2058 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
COLO 205	GI₅₀	50.1 nM Compound: 21	Antiproliferative activity against human COLO 205 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human COLO 205 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
HCC44	GI₅₀	0.035 μM Compound: 21	Antiproliferative activity against human HCC44 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human HCC44 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
HEK293	GI₅₀	1.67 μM Compound: 21	Antiproliferative activity against human HEK293 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human HEK293 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
MCF7	GI₅₀	0.044 μM Compound: 21	Antiproliferative activity against human MCF7 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
MDA-MB-231	GI₅₀	0.73 μM Compound: 21	Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
MDA-MB-435	GI₅₀	< 10 nM Compound: 21	Antiproliferative activity against human MDA-MB-435 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-435 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
MIA PaCa-2	GI₅₀	0.081 μM Compound: 21	Antiproliferative activity against human MIA PaCa-2 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human MIA PaCa-2 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
OVCAR-8	GI₅₀	49 nM Compound: 21	Antiproliferative activity against human OVCAR-8 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human OVCAR-8 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
PANC-1	GI₅₀	6.5 μM Compound: 21	Antiproliferative activity against human PANC-1 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human PANC-1 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
RPMI-8226	GI₅₀	31.6 nM Compound: 21	Antiproliferative activity against human RPMI-8226 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human RPMI-8226 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
RXF 393	GI₅₀	21.4 nM Compound: 21	Antiproliferative activity against human RXF 393 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human RXF 393 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
SK-MEL-2	GI₅₀	25.7 nM Compound: 21	Antiproliferative activity against human SK-MEL-2 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human SK-MEL-2 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
SN12C	GI₅₀	38 nM Compound: 21	Antiproliferative activity against human SN12C cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human SN12C cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
SNB-75	GI₅₀	26.9 nM Compound: 21	Antiproliferative activity against human SNB-75 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human SNB-75 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
SR	GI₅₀	< 10 nM Compound: 21	Antiproliferative activity against human SR cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human SR cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
U-937	GI₅₀	0.011 μM Compound: 21	Antiproliferative activity against human U-937 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human U-937 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
UACC-62	GI₅₀	28.2 nM Compound: 21	Antiproliferative activity against human UACC-62 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human UACC-62 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]

Molecular Weight

669.72

Formula

C₃₆H₃₉N₅O₈

SMILES

O=C1NC2=CC=C(C[C@@H]3NC([C@@H](O)C(C)C)=O)C=C2[C@@]1(C)C4=C(C5=NC(C(OCC6=CC=CC=C6)=O)=CO5)N=C(O4)[C@H](C(C)(C)C)NC3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kalnins T, et al. Development of Potent Microtubule Targeting Agent by Structural Simplification of Natural Diazonamide. J Med Chem. 2024 Jun 13;67(11):9227-9259. [Content Brief]