country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-161747

Copy Link Print Information

Tubulin inhibitor 46

Tubulin inhibitor 46 (Compound 21) is a potent tubulin assembly inhibitor. Tubulin inhibitor 46 has antiproliferative activities, with GI₅₀ values of 0.0095-33 μM for cancer and non-cancerous cells. Tubulin inhibitor 46 can be used for the reserch of cancer.

For research use only. We do not sell to patients.

Formula: C₃₆H₃₉N₅O₈
Molecular Weight:669.72

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Tubulin inhibitor 46 Chemical Structure

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2058	GI₅₀	0.01 μM Compound: 21	Antiproliferative activity against human A2058 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human A2058 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
COLO 205	GI₅₀	50.1 nM Compound: 21	Antiproliferative activity against human COLO 205 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human COLO 205 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
HCC44	GI₅₀	0.035 μM Compound: 21	Antiproliferative activity against human HCC44 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human HCC44 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
HEK293	GI₅₀	1.67 μM Compound: 21	Antiproliferative activity against human HEK293 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human HEK293 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
MCF7	GI₅₀	0.044 μM Compound: 21	Antiproliferative activity against human MCF7 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
MDA-MB-231	GI₅₀	0.73 μM Compound: 21	Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
MDA-MB-435	GI₅₀	<10 nM Compound: 21	Antiproliferative activity against human MDA-MB-435 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-435 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
MIA PaCa-2	GI₅₀	0.081 μM Compound: 21	Antiproliferative activity against human MIA PaCa-2 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human MIA PaCa-2 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
OVCAR-8	GI₅₀	49 nM Compound: 21	Antiproliferative activity against human OVCAR-8 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human OVCAR-8 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
PANC-1	GI₅₀	6.5 μM Compound: 21	Antiproliferative activity against human PANC-1 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human PANC-1 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
RPMI-8226	GI₅₀	31.6 nM Compound: 21	Antiproliferative activity against human RPMI-8226 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human RPMI-8226 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
RXF 393	GI₅₀	21.4 nM Compound: 21	Antiproliferative activity against human RXF 393 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human RXF 393 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
SK-MEL-2	GI₅₀	25.7 nM Compound: 21	Antiproliferative activity against human SK-MEL-2 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human SK-MEL-2 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
SN12C	GI₅₀	38 nM Compound: 21	Antiproliferative activity against human SN12C cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human SN12C cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
SNB-75	GI₅₀	26.9 nM Compound: 21	Antiproliferative activity against human SNB-75 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human SNB-75 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
SR	GI₅₀	<10 nM Compound: 21	Antiproliferative activity against human SR cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human SR cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
U-937	GI₅₀	0.011 μM Compound: 21	Antiproliferative activity against human U-937 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human U-937 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
UACC-62	GI₅₀	28.2 nM Compound: 21	Antiproliferative activity against human UACC-62 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human UACC-62 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]

Chemical Information

Molecular Weight 669.72
Formula C₃₆H₃₉N₅O₈
SMILES

O=C1NC2=CC=C(C[C@@H]3NC([C@@H](O)C(C)C)=O)C=C2[C@@]1(C)C4=C(C5=NC(C(OCC6=CC=CC=C6)=O)=CO5)N=C(O4)[C@H](C(C)(C)C)NC3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kalnins T, et al. Development of Potent Microtubule Targeting Agent by Structural Simplification of Natural Diazonamide. J Med Chem. 2024 Jun 13;67(11):9227-9259. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote