Tubulin inhibitor 46

製品番号: HY-161747: Data Sheet 取扱説明書
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Tubulin inhibitor 46 (Compound 21) is a potent tubulin assembly inhibitor. Tubulin inhibitor 46 has antiproliferative activities, with GI₅₀ values of 0.0095-33 μM for cancer and non-cancerous cells. Tubulin inhibitor 46 can be used for the reserch of cancer.

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Tubulin inhibitor 46 構造式

容量		在庫状況
MOQ		Minimum order quantity
50 mg		お問い合わせ
100 mg		お問い合わせ
250 mg		お問い合わせ
Other size		お問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A2058	GI₅₀	0.01 μM Compound: 21	Antiproliferative activity against human A2058 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human A2058 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
COLO 205	GI₅₀	50.1 nM Compound: 21	Antiproliferative activity against human COLO 205 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human COLO 205 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
HCC44	GI₅₀	0.035 μM Compound: 21	Antiproliferative activity against human HCC44 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human HCC44 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
HEK293	GI₅₀	1.67 μM Compound: 21	Antiproliferative activity against human HEK293 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human HEK293 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
MCF7	GI₅₀	0.044 μM Compound: 21	Antiproliferative activity against human MCF7 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
MDA-MB-231	GI₅₀	0.73 μM Compound: 21	Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
MDA-MB-435	GI₅₀	< 10 nM Compound: 21	Antiproliferative activity against human MDA-MB-435 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-435 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
MIA PaCa-2	GI₅₀	0.081 μM Compound: 21	Antiproliferative activity against human MIA PaCa-2 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human MIA PaCa-2 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
OVCAR-8	GI₅₀	49 nM Compound: 21	Antiproliferative activity against human OVCAR-8 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human OVCAR-8 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
PANC-1	GI₅₀	6.5 μM Compound: 21	Antiproliferative activity against human PANC-1 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human PANC-1 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
RPMI-8226	GI₅₀	31.6 nM Compound: 21	Antiproliferative activity against human RPMI-8226 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human RPMI-8226 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
RXF 393	GI₅₀	21.4 nM Compound: 21	Antiproliferative activity against human RXF 393 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human RXF 393 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
SK-MEL-2	GI₅₀	25.7 nM Compound: 21	Antiproliferative activity against human SK-MEL-2 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human SK-MEL-2 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
SN12C	GI₅₀	38 nM Compound: 21	Antiproliferative activity against human SN12C cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human SN12C cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
SNB-75	GI₅₀	26.9 nM Compound: 21	Antiproliferative activity against human SNB-75 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human SNB-75 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
SR	GI₅₀	< 10 nM Compound: 21	Antiproliferative activity against human SR cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human SR cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
U-937	GI₅₀	0.011 μM Compound: 21	Antiproliferative activity against human U-937 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human U-937 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]
UACC-62	GI₅₀	28.2 nM Compound: 21	Antiproliferative activity against human UACC-62 cells assessed as growth inhibition measured for 48 hrs by MTT assay Antiproliferative activity against human UACC-62 cells assessed as growth inhibition measured for 48 hrs by MTT assay	[PMID: 38833507]

分子量

669.72

分子式

C₃₆H₃₉N₅O₈

SMILES

O=C1NC2=CC=C(C[C@@H]3NC([C@@H](O)C(C)C)=O)C=C2[C@@]1(C)C4=C(C5=NC(C(OCC6=CC=CC=C6)=O)=CO5)N=C(O4)[C@H](C(C)(C)C)NC3=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kalnins T, et al. Development of Potent Microtubule Targeting Agent by Structural Simplification of Natural Diazonamide. J Med Chem. 2024 Jun 13;67(11):9227-9259. [Content Brief]