2. PROTAC Cell Cycle/DNA Damage
  3. PROTACs CDK
  4. SNX7886

SNX7886 is a CDK8/CDK19 PROTAC degrader. SNX7886 promotes the ubiquitination and degradation of CDK8 and CDK19. SNX7886 also promotes the degradation of CCNC. SNX7886 can be used in cancer research.
(Pink: CDK8 and CDK19 ligand (HY-168683); Blue: Cereblon ligand (HY-131875); Black: linker).

For research use only. We do not sell to patients.

SNX7886

SNX7886 Chemical Structure

CAS No. : 2924557-42-4

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500 μg In-stock
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SNX7886 Related Antibodies

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Description

SNX7886 is a CDK8/CDK19 PROTAC degrader. SNX7886 promotes the ubiquitination and degradation of CDK8 and CDK19. SNX7886 also promotes the degradation of CCNC. SNX7886 can be used in cancer research[1]. (Pink: CDK8 and CDK19 ligand (HY-168683); Blue: Cereblon ligand (HY-131875); Black: linker).

IC50 & Target[1]

CDK8

 

CDK19

 

In Vitro

SNX7886 (30 nM-1 μM; 24 h) potently degrades CDK8, CDK19, and their binding partner CCNC in human embryonic kidney 293 cells, with maximal degradation observed at concentrations as low as 30 nM after 24 h of treatment[1].
SNX7886 (200 nM; 72 h) induces kinase-dependent transcriptomic changes in human embryonic kidney 293 cells, altering expression of 1435 high-confidence DEGs after 72 h of 200 nM treatment, with effects largely overlapping those of the CDK8/19 kinase inhibitor BI1347[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SNX7886 Related Antibodies

Western Blot Analysis[1]

Cell Line: human embryonic kidney 293 cells
Concentration: 30 nM, 100 nM, 300 nM, 1 μM
Incubation Time: 24 h
Result: Degraded CDK8 by up to 90% and CDK19 by up to 80%, with concurrent degradation of CCNC.
Maintained degradation of CDK8, CDK19, and CCNC at 100 nM, 300 nM, and 1 μM concentrations.
Molecular Weight

922.08

Formula

C52H59N9O7
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(NCCCC(NCCCCCCCCCCC(N4CCN(CC4)C(CN5N=CC(C6=CC=C(C7=C8C=CC=CC8=CN=C7)C=C6)=C5)=O)=O)=O)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (108.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0845 mL 5.4225 mL 10.8450 mL
5 mM 0.2169 mL 1.0845 mL 2.1690 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0845 mL 5.4225 mL 10.8450 mL 27.1126 mL
5 mM 0.2169 mL 1.0845 mL 2.1690 mL 5.4225 mL
10 mM 0.1085 mL 0.5423 mL 1.0845 mL 2.7113 mL
15 mM 0.0723 mL 0.3615 mL 0.7230 mL 1.8075 mL
20 mM 0.0542 mL 0.2711 mL 0.5423 mL 1.3556 mL
25 mM 0.0434 mL 0.2169 mL 0.4338 mL 1.0845 mL
30 mM 0.0362 mL 0.1808 mL 0.3615 mL 0.9038 mL
40 mM 0.0271 mL 0.1356 mL 0.2711 mL 0.6778 mL
50 mM 0.0217 mL 0.1085 mL 0.2169 mL 0.5423 mL
60 mM 0.0181 mL 0.0904 mL 0.1808 mL 0.4519 mL
80 mM 0.0136 mL 0.0678 mL 0.1356 mL 0.3389 mL
100 mM 0.0108 mL 0.0542 mL 0.1085 mL 0.2711 mL
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SNX7886 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SNX78862924557-42-4SNX 7886SNX-7886PROTACsCDKCyclin dependent kinasecyclin Cmammalian cellshuman embryonic kidney 293 cellsBI1347CDK8/19 kinase inhibitorCDK8CDK19CCNCInhibitorinhibitorinhibit

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